MATK (CSK homologous kinase) binds phosphorylated ERBB2

Stable Identifier
R-HSA-1963563
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
Locations in the PathwayBrowser
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Summation

MATK (also known as CHK or CSK homologous kinase) binds to ERBB2 through phosphorylated tyrosine residue Y1253 in the C-tail of ERBB2 and, through an unknown mechanism, inhibits ERBB2 downstream signaling.

Literature References
PubMed ID Title Journal Year
9461599 Csk homologous kinase, a novel signaling molecule, directly associates with the activated ErbB-2 receptor in breast cancer cells and inhibits their proliferation

Zrihan-Licht, S, Deng, B, Yarden, Y, McShan, G, Keydar, I, Avraham, H

J Biol Chem 1998
Participants
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Output
Participant Of
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Orthologous Events
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Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Neckers, LM  (2011-11-11)
Xu, W  (2011-11-11)
Created
Orlic-Milacic, M  (2011-11-04)