MATK (CSK homologous kinase) binds phosphorylated ERBB2

Stable Identifier
R-HSA-1963563
Type
Reaction
Species
Homo sapiens
Compartment
extracellular region, plasma membrane, cytosol
Locations in the PathwayBrowser
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Summation

MATK (also known as CHK or CSK homologous kinase) binds to ERBB2 through phosphorylated tyrosine residue Y1253 in the C-tail of ERBB2 and, through an unknown mechanism, inhibits ERBB2 downstream signaling.

Literature References
PubMed ID Title Journal Year
9461599 Csk homologous kinase, a novel signaling molecule, directly associates with the activated ErbB-2 receptor in breast cancer cells and inhibits their proliferation

Zrihan-Licht, S, Deng, B, Yarden, Y, McShan, G, Keydar, I, Avraham, H

J Biol Chem 1998
Participants
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Output
Participant Of
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Orthologous Events
MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Bos taurus)
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MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Danio rerio)
MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Gallus gallus)
MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Mus musculus)
MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Rattus norvegicus)
MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Sus scrofa)
MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Taeniopygia guttata)
MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Neckers, LM  (2011-11-11)
Xu, W  (2011-11-11)