MATK (CSK homologous kinase) binds phosphorylated ERBB2

Stable Identifier
R-HSA-1963563
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MATK (CSK homologous kinase) binds phosphorylated ERBB2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

MATK (also known as CHK or CSK homologous kinase) binds to ERBB2 through phosphorylated tyrosine residue Y1253 in the C-tail of ERBB2 and, through an unknown mechanism, inhibits ERBB2 downstream signaling.

Literature References
PubMed ID Title Journal Year
9461599 Csk homologous kinase, a novel signaling molecule, directly associates with the activated ErbB-2 receptor in breast cancer cells and inhibits their proliferation

McShan, G, Zrihan-Licht, S, Avraham, H, Keydar, I, Yarden, Y, Deng, B

J Biol Chem 1998
Participants
Input
Output
Participates
as an event of
Orthologous Events
MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Bos taurus)
MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Caenorhabditis elegans)
MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Canis familiaris)
MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Danio rerio)
MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Drosophila melanogaster)
MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Gallus gallus)
MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Mus musculus)
MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Rattus norvegicus)
MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Sus scrofa)
MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Neckers, LM  (2011-11-11)
Xu, W  (2011-11-11)
Created
Orlic-Milacic, M  (2011-11-04)
Cite Us!