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Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane
Stable Identifier
R-HSA-196086
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
,
mitochondrial intermembrane space
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Metabolism of steroid hormones (Homo sapiens)
Pregnenolone biosynthesis (Homo sapiens)
Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Cholesterol is released from its complex with STAR in the mitochondrial intermembrane space. The mechanism of this process in vivo remains incompletely understood.
Literature References
PubMed ID
Title
Journal
Year
16973755
StAR search--what we know about how the steroidogenic acute regulatory protein mediates mitochondrial cholesterol import
Miller, WL
Mol Endocrinol
2007
Participants
Input
STAR:CHOL [mitochondrial intermembrane space]
(Homo sapiens)
Output
CHOL [mitochondrial inner membrane]
STAR [mitochondrial intermembrane space]
(Homo sapiens)
Participates
as an event of
Pregnenolone biosynthesis (Homo sapiens)
Orthologous Events
Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Bos taurus)
Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Canis familiaris)
Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Danio rerio)
Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Gallus gallus)
Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Mus musculus)
Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Rattus norvegicus)
Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Sus scrofa)
Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Xenopus tropicalis)
Authored
Jassal, B (2008-10-01)
Reviewed
D'Eustachio, P (2007-04-21)
Created
D'Eustachio, P (2007-04-17)
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