Dab2 is recruited to the junctional plaques

Stable Identifier
R-HSA-196026
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Dab2 is recruited to Cx43-based GJs possibly through a direct interaction between its N-terminal phosphotyrosine binding (PTB) domain and a putative XPXY internalization motif found in the C-terminal tail of Cx43 as well as a number of other connexin family members (Piehl et al., 2007).The distal portion of Dab2 on its opposite end binds the globular N-terminal domain of clathrin heavy chains (Piehl et al., 2007).
Literature References
PubMed ID Title Journal Year
17108328 Internalization of Large Double-Membrane Intercellular Vesicles by a Clathrin-dependent Endocytic Process

Gumpert, A, Segretain, D, Falk, MM, Piehl, M, Denizot, JP, Lehmann, C

Mol Biol Cell 2007
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!