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Dab2 is recruited to the junctional plaques
Stable Identifier
R-HSA-196026
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Gap junction trafficking and regulation (Homo sapiens)
Gap junction trafficking (Homo sapiens)
Gap junction degradation (Homo sapiens)
Formation of annular gap junctions (Homo sapiens)
Dab2 is recruited to the junctional plaques (Homo sapiens)
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Dab2 is recruited to Cx43-based GJs possibly through a direct interaction between its N-terminal phosphotyrosine binding (PTB) domain and a putative XPXY internalization motif found in the C-terminal tail of Cx43 as well as a number of other connexin family members (Piehl et al., 2007).The distal portion of Dab2 on its opposite end binds the globular N-terminal domain of clathrin heavy chains (Piehl et al., 2007).
Literature References
PubMed ID
Title
Journal
Year
17108328
Internalization of Large Double-Membrane Intercellular Vesicles by a Clathrin-dependent Endocytic Process
Gumpert, A
,
Segretain, D
,
Falk, MM
,
Piehl, M
,
Denizot, JP
,
Lehmann, C
Mol Biol Cell
2007
Participants
Input
DAB2 [plasma membrane]
(Homo sapiens)
planar gap junction plaques [plasma membrane]
(Homo sapiens)
Output
planar gap junction plaques associated with Dab2 [plasma membrane]
(Homo sapiens)
Participates
as an event of
Formation of annular gap junctions (Homo sapiens)
Orthologous Events
Dab2 is recruited to the junctional plaques (Bos taurus)
Dab2 is recruited to the junctional plaques (Canis familiaris)
Dab2 is recruited to the junctional plaques (Gallus gallus)
Dab2 is recruited to the junctional plaques (Mus musculus)
Dab2 is recruited to the junctional plaques (Rattus norvegicus)
Dab2 is recruited to the junctional plaques (Sus scrofa)
Dab2 is recruited to the junctional plaques (Xenopus tropicalis)
Authored
Gilleron, J (2007-01-03)
Segretain, D (2007-01-03)
Falk, MM (2007-01-03)
Reviewed
Falk, MM (2007-02-02)
Created
Matthews, L (2007-04-17)
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