Association with M1 at cell membrane

Stable Identifier
R-HSA-195926
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

As influenza viruses bud from the plasma membrane of infected cells, complete virions are not seen inside cells. In polarized epithelial cells, assembly and budding of influenza occurs from the apical plasma membrane (Schmitt, 2004). For efficient assembly, all virion components must accumulate at the budding site, and it is believed that the viral glycoprotein accumulation determines the site of virus assembly and budding (Nayak, 2004). M1 is thought to be the bridge between the envelope glycoproteins and the RNPs for assembly (Schmitt, 2004). M2 is also required, because if it is not present RNPs are not packaged into budding virions (McCown, 2005), however it role is not known.

Literature References
PubMed ID Title Journal Year
15298170 Escaping from the cell: assembly and budding of negative-strand RNA viruses

Schmitt, AP, Lamb, RA

Curr Top Microbiol Immunol 2004
15731254 The influenza A virus M2 cytoplasmic tail is required for infectious virus production and efficient genome packaging

McCown, MF, Pekosz, A

J Virol 2005
15567494 Assembly and budding of influenza virus

Nayak, DP, Hui, EK, Barman, S

Virus Res 2004
Participants
Participant Of
Disease
Name Identifier Synonyms
influenza 8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Authored
Reviewed
Created