Association with M1 at cell membrane

Stable Identifier
Reaction [binding]
Homo sapiens
Related Species
Influenza A virus
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As influenza viruses bud from the plasma membrane of infected cells, complete virions are not seen inside cells. In polarized epithelial cells, assembly and budding of influenza occurs from the apical plasma membrane (Schmitt, 2004). For efficient assembly, all virion components must accumulate at the budding site, and it is believed that the viral glycoprotein accumulation determines the site of virus assembly and budding (Nayak, 2004). M1 is thought to be the bridge between the envelope glycoproteins and the RNPs for assembly (Schmitt, 2004). M2 is also required, because if it is not present RNPs are not packaged into budding virions (McCown, 2005), however it role is not known.

Literature References
PubMed ID Title Journal Year
15731254 The influenza A virus M2 cytoplasmic tail is required for infectious virus production and efficient genome packaging

McCown, MF, Pekosz, A

J Virol 2005
15298170 Escaping from the cell: assembly and budding of negative-strand RNA viruses

Schmitt, AP, Lamb, RA

Curr Top Microbiol Immunol 2004
15567494 Assembly and budding of influenza virus

Barman, S, Nayak, DP, Hui, EK

Virus Res 2004
Name Identifier Synonyms
influenza DOID:8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
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