Reactome | TIMM9:TIMM10 transfers proteins to TIMM22

TIMM9:TIMM10 transfers proteins to TIMM22

Stable Identifier

R-HSA-1955380

Type

Reaction [binding]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

TIMM9:TIMM10 transfers proteins to TIMM22

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TIMM9:TIMM10 with bound substrate protein interacts with FXC1 (TIMM9B, TIMM10B) and TIMM22 at the inner membrane (Muhlenbein et al. 2004). It is believed that TIMM22 then inserts the protein into the inner membrane and TIMM9:TIMM10 and FXC1 are released.

Literature References

PubMed ID	Title	Journal	Year
19453276	Multiple pathways for mitochondrial protein traffic Yamano, K, Endo, T	Biol Chem	2009
18174896	Multiple pathways for sorting mitochondrial precursor proteins Pfanner, N, Wagner, R, Sickmann, A, Bolender, N, Meisinger, C	EMBO Rep	2008
14726512	Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria Hofmann, S, Rothbauer, U, Mühlenbein, N, Bauer, MF	J Biol Chem	2004