NRP-2 associates with VEGFR1 forming complexes on cell surface

Stable Identifier
R-HSA-195418
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane
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NRP-2 associates with VEGFR1 forming complexes on cell surface
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NRP-2 associates with VEGFR-1 on the plasma membrane. As NRP-2 lacks an intracellular domain, this association may be the means by which NRP-2 participates in VEGF-induced signaling. This interaction requires VEGF to bridge between NRP and the receptor.

Literature References
PubMed ID Title Journal Year
11278319 Vascular endothelial growth factor receptor-1 and neuropilin-2 form complexes

Shibuya, M, Cohen, T, Gluzman-Poltorak, Z, Neufeld, G

J Biol Chem 2001
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Orthologous Events
NRP-2 associates with VEGFR1 forming complexes on cell surface (Canis familiaris)
NRP-2 associates with VEGFR1 forming complexes on cell surface (Danio rerio)
NRP-2 associates with VEGFR1 forming complexes on cell surface (Gallus gallus)
NRP-2 associates with VEGFR1 forming complexes on cell surface (Mus musculus)
NRP-2 associates with VEGFR1 forming complexes on cell surface (Rattus norvegicus)
NRP-2 associates with VEGFR1 forming complexes on cell surface (Sus scrofa)
NRP-2 associates with VEGFR1 forming complexes on cell surface (Xenopus tropicalis)
Authored
Garapati, P V  (2013-08-30)
Reviewed
Claesson-Welsh, L  (2008-02-28)
Created
Gopinathrao, G  (2007-04-06)
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