Reactome | VEGF binds to VEGFR leading to receptor dimerization

VEGF binds to VEGFR leading to receptor dimerization

Stable Identifier

R-HSA-195399

Type

Pathway

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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VEGF binds to VEGFR leading to receptor dimerization

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The binding of VEGF ligands to VEGFR receptors in the cell membrane induces dimerization and activation of the latter, initiating intracellular signaling cascades that result in proliferation, survival, migration and increased permeability of vascular endothelial cells (Matsumoto and Mugishima, 2006). The receptors predominantly form homodimers but heterodimers between VEGFR-1 and -2 have been observed. Although both VEGFR-1 and -2 are expressed in the vascular endothelium, the angiogenic activities of VEGFs are transduced mainly through VEGFR-2 in vivo.

Literature References

PubMed ID	Title	Journal	Year
16633338	VEGF receptor signalling - in control of vascular function Dimberg, A, Kreuger, J, Olsson, AK, Claesson-Welsh, L	Nat Rev Mol Cell Biol	2006
16835467	Signal transduction via vascular endothelial growth factor (VEGF) receptors and their roles in atherogenesis Matsumoto, T, Mugishima, H	J Atheroscler Thromb	2006
13678960	VEGF-receptor signal transduction Matsumoto, T, Cross, MJ, Dixelius, J, Claesson-Welsh, L	Trends Biochem Sci	2003