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FLT4 [plasma membrane]
Stable Identifier
R-HSA-195359
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
VEGFR3
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Response of endothelial cells to shear stress (Homo sapiens)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
Phosphorylation of KDR (VEGFR2) and FLT4 (VEGFR3) and PECAM1 in PECAM1:CDH5:KDR:FLT4:CTNNB1 (Homo sapiens)
PECAM1:CDH5:KDR:FLT4:CTNNB1 [plasma membrane] (Homo sapiens)
FLT4 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
NOTCH4 Intracellular Domain Regulates Transcription (Homo sapiens)
FLT4 gene expression is stimulated by NOTCH4 (Homo sapiens)
FLT4 [plasma membrane] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGF ligand-receptor interactions (Homo sapiens)
VEGF binds to VEGFR leading to receptor dimerization (Homo sapiens)
VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Homo sapiens)
FLT4 [plasma membrane] (Homo sapiens)
VEGFR3 dimer:VEGFC, VEGFD dimers [plasma membrane] (Homo sapiens)
VEGFR3 dimer [plasma membrane] (Homo sapiens)
FLT4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35916 FLT4
Gene Names
FLT4, VEGFR3
Chain
signal peptide:1-24, chain:25-1363
Reference Genes
BioGPS Gene:2324 FLT4
COSMIC (genes):FLT4 FLT4
CTD Gene:2324 FLT4
dbSNP Gene:2324 FLT4
ENSEMBL:ENSG00000037280 FLT4
ENSEMBL_homo_sapiens_GENE:ENSG00000037280.16 FLT4
HGNC:3767 FLT4
KEGG Gene (Homo sapiens):2324 FLT4
Monarch:2324 FLT4
NCBI Gene:2324 FLT4
OMIM:136352 FLT4
UCSC:P35916 FLT4
Reference Transcript
RefSeq:NM_182925.4 FLT4
RefSeq:NM_002020.4 FLT4
Other Identifiers
11726169_at
11726170_at
11740292_a_at
11750407_a_at
11753432_a_at
11753542_a_at
17003958
210316_PM_at
210316_at
229902_PM_at
229902_at
2324
234379_PM_at
234379_at
2890757
2890758
2890759
2890760
2890761
2890765
2890766
2890768
2890769
2890770
2890775
2890776
2890777
2890778
2890779
2890782
2890783
2890784
2890785
2890786
2890787
2890788
2890789
2890790
2890791
2890793
2890794
2890796
2890797
2890798
2890799
2890800
2890808
2890809
403_s_at
55409_at
8116445
A_23_P213394
A_23_P356070
A_24_P926979
GE81101
GE85623
GO:0000166
GO:0001525
GO:0001934
GO:0001938
GO:0001944
GO:0001945
GO:0001946
GO:0002040
GO:0003016
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0005021
GO:0005515
GO:0005524
GO:0005576
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0006468
GO:0007169
GO:0007585
GO:0008284
GO:0010575
GO:0010595
GO:0012501
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0019838
GO:0019903
GO:0023052
GO:0030335
GO:0031401
GO:0035924
GO:0036211
GO:0038084
GO:0042803
GO:0043066
GO:0043226
GO:0043235
GO:0043408
GO:0043410
GO:0045937
GO:0046330
GO:0046777
GO:0048010
GO:0048286
GO:0048514
GO:0048584
GO:0048856
GO:0048870
GO:0060089
GO:0060312
GO:0070374
GO:0090037
GO:0140096
HMNXSV003009332
HMNXSV003026463
Hs.248032.0.S1_3p_at
Hs.8941.0.A1_3p_at
ILMN_1651296
ILMN_1794741
ILMN_2390427
PH_hs_0033241
TC05002148.hg
TC05003386.hg
X69878_at
g1150990_3p_at
Participates
as a component of
PECAM1:CDH5:KDR:FLT4:CTNNB1 [plasma membrane] (Homo sapiens)
VEGFR3 dimer [plasma membrane] (Homo sapiens)
as an output of
FLT4 gene expression is stimulated by Notch4 (Homo sapiens)
FLT4 gene expression is stimulated by NOTCH4 (Homo sapiens)
as an input of
VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Homo sapiens)
Other forms of this molecule
p-Y1063,Y1230-FLT4 [plasma membrane]
Inferred To
FLT4 [plasma membrane]
(Bos taurus)
FLT4 [plasma membrane]
(Canis familiaris)
FLT4 [plasma membrane]
(Danio rerio)
FLT4 [plasma membrane]
(Gallus gallus)
FLT4 [plasma membrane]
(Rattus norvegicus)
FLT4 [plasma membrane]
(Sus scrofa)
FLT4 [plasma membrane]
(Xenopus tropicalis)
Flt4 [plasma membrane]
(Mus musculus)
Cross References
RefSeq
NP_891555.2
,
NP_002011.2
ZINC - World Drugs
VGFR3_HUMAN
Guide to Pharmacology - Targets
1814
OpenTargets
ENSG00000037280
ZINC - FDA approved
VGFR3_HUMAN
ZINC - Substances
VGFR3_HUMAN
ZINC - Biogenic
VGFR3_HUMAN
ZINC target
P35916
PRO
P35916
PDB
4BSK
,
4BSJ
ZINC - Investigational
VGFR3_HUMAN
ZINC - Metabolites
VGFR3_HUMAN
IntEnz
2.7.10.1
HPA
ENSG00000037280-FLT4
GeneCards
P35916
Ensembl
ENST00000261937
,
ENSP00000377016
,
ENSP00000261937
,
ENSG00000037280
,
ENST00000393347
Pharos - Targets
P35916
ZINC - Predictions - Purchasable
VGFR3_HUMAN
Orphanet
16061
HMDB Protein
HMDBP01160
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35968 KDR
5
p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane]
(R-HSA-9673636)
VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane]
(R-HSA-9673613)
p-Y801,Y1054,Y1175-KDR [plasma membrane]
(R-HSA-9860484)
VEGFR2 [plasma membrane]
(R-HSA-195382)
p-6Y-VEGFR2 [plasma membrane]
(R-HSA-4420103)
0.702
5
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.641
3
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