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RAC2
Stable Identifier
R-HSA-195343
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Rac2
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
GPVI-mediated activation cascade (Homo sapiens)
VAV1 is a GEF for Rho/Rac family kinases (Homo sapiens)
VAV1 Rho/Rac effectors:GDP [cytosol] (Homo sapiens)
VAV1 effectors [cytosol] (Homo sapiens)
RAC2 [cytosol] (Homo sapiens)
VAV1 Rho/Rac effectors:GTP [cytosol] (Homo sapiens)
VAV1 effectors [cytosol] (Homo sapiens)
RAC2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (12/13) signalling events (Homo sapiens)
Rac1 activation of PI3K (Homo sapiens)
Activated Rac1:PI3K alpha [cytosol] (Homo sapiens)
VAV1 Rho/Rac effectors:GTP [cytosol] (Homo sapiens)
VAV1 effectors [cytosol] (Homo sapiens)
RAC2 [cytosol] (Homo sapiens)
VAV1 Rho/Rac effectors:GTP [cytosol] (Homo sapiens)
VAV1 effectors [cytosol] (Homo sapiens)
RAC2 [cytosol] (Homo sapiens)
p115-RhoGEF activation of Rac1 (Homo sapiens)
VAV1 Rho/Rac effectors:GDP [cytosol] (Homo sapiens)
VAV1 effectors [cytosol] (Homo sapiens)
RAC2 [cytosol] (Homo sapiens)
VAV1 Rho/Rac effectors:GTP [cytosol] (Homo sapiens)
VAV1 effectors [cytosol] (Homo sapiens)
RAC2 [cytosol] (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
Rho GTPase cycle (Homo sapiens)
Dissociation of Rho GTP:GDP from GDI complex (Homo sapiens)
Inactivated RhoGTPase:GDP:GDI complex [cytosol] (Homo sapiens)
RhoGTPase:GDP [cytosol] (Homo sapiens)
Rho GTPases [cytosol] (Homo sapiens)
Rac [cytosol] (Homo sapiens)
RAC2 [cytosol] (Homo sapiens)
RhoGTPase:GDP [cytosol] (Homo sapiens)
Rho GTPases [cytosol] (Homo sapiens)
Rac [cytosol] (Homo sapiens)
RAC2 [cytosol] (Homo sapiens)
GDIs block activation of Rho GTPase:GDP (Homo sapiens)
Inactivated RhoGTPase:GDP:GDI complex [cytosol] (Homo sapiens)
RhoGTPase:GDP [cytosol] (Homo sapiens)
Rho GTPases [cytosol] (Homo sapiens)
Rac [cytosol] (Homo sapiens)
RAC2 [cytosol] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
PCP/CE pathway (Homo sapiens)
ppDVL recruits RAC (Homo sapiens)
RAC:GTP [cytosol] (Homo sapiens)
RAC [cytosol] (Homo sapiens)
RAC2 [cytosol] (Homo sapiens)
ppDVL:RAC:GTP [cytosol] (Homo sapiens)
RAC:GTP [cytosol] (Homo sapiens)
RAC [cytosol] (Homo sapiens)
RAC2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P15153 RAC2
Gene Names
RAC2
Chain
chain:1-189, propeptide:190-192
Reference Genes
BioGPS Gene:5880 RAC2
COSMIC (genes):RAC2 RAC2
CTD Gene:5880 RAC2
dbSNP Gene:5880 RAC2
ENSEMBL:ENSG00000128340 RAC2
HGNC:9802 RAC2
KEGG Gene (Homo sapiens):hsa:5880 RAC2
Monarch:5880 RAC2
NCBI Gene:5880 RAC2
OMIM:602049 RAC2
UCSC:P15153 RAC2
Reference Transcript
RefSeq:NM_002872.4 RAC2
Other Identifiers
0002690095
11744263_s_at
1DS6
207419_3p_s_at
207419_s_at
213603_s_at
22946
2W2T
2W2V
2W2X
32736_at
32737_at
47820
5880
8075910
A0A024R1P2
A_23_P218770
A_23_P218774
A_24_P228717
AAA35941
AAA36538
AAH01485
AAM21112
AAP35565
AF498965
B1AH79
B1AH80
BC001485
BT006919
CAB022946
CAG30441
CCDS13945
CH471095
CR456555
EAW60149
EAW60153
ENSG00000128340
ENSP00000249071
ENST00000249071
EntrezGene:5880
GE80267
GE81848
GO:0000166
GO:0002376
GO:0003674
GO:0003924
GO:0005525
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005635
GO:0005737
GO:0005829
GO:0005856
GO:0005884
GO:0005886
GO:0005925
GO:0006464
GO:0006605
GO:0006810
GO:0006935
GO:0006950
GO:0007005
GO:0007010
GO:0007015
GO:0007155
GO:0007165
GO:0007186
GO:0007264
GO:0008150
GO:0008283
GO:0008284
GO:0010310
GO:0010592
GO:0010810
GO:0016020
GO:0016192
GO:0019887
GO:0022607
GO:0030027
GO:0030031
GO:0030036
GO:0030168
GO:0030234
GO:0030670
GO:0031410
GO:0040011
GO:0042129
GO:0042592
GO:0043167
GO:0043226
GO:0043304
GO:0045453
GO:0045859
GO:0048870
GO:0051056
GO:0060263
GO:0060753
GO:0070062
GO:0071593
GO:0090023
GO:1902622
GO:1903955
HGNC:9802
HPA047820
Hs.301175.1.S1_3p_s_at
ILMN_1709795
IPR001806
IPR005225
IPR027417
LRG_97
M29871
M64595
M64595_at
MIM:602049
MIM:608203
NM_002872
NP_002863
PF00071
PH_hs_0015519
PR00449
RAC2
RAC2-201
SM00173
SM00174
SM00175
SM00176
TC22000725.hg
uc003arc.5
UPI00001110AB
XM_006724286
XP_006724349
Z82188
Participant Of
hasCandidate
RAC [cytosol]
hasMember
Rac [cytosol]
VAV1 effectors [cytosol]
Other forms of this molecule
RAC2 [plasma membrane]
RAC2 [phagocytic vesicle membrane]
Inferred To
RAC2 [cytosol] (Bos taurus)
RAC2 [cytosol] (Canis familiaris)
RAC2 [cytosol] (Danio rerio)
RAC2 [cytosol] (Drosophila melanogaster)
RAC2 [cytosol] (Gallus gallus)
RAC2 [cytosol] (Mus musculus)
RAC2 [cytosol] (Rattus norvegicus)
RAC2 [cytosol] (Sus scrofa)
RAC2 [cytosol] (Taeniopygia guttata)
RAC2 [cytosol] (Xenopus tropicalis)
Homologues of RAC2 [cytosol] (Danio rerio)
Homologues of RAC2 [cytosol] (Drosophila melanogaster)
Homologues of RAC2 [cytosol] (Xenopus tropicalis)
RAC1 [cytosol] (Caenorhabditis elegans)
RAC1 [cytosol] (Dictyostelium discoideum)
RAC1 [cytosol] (Drosophila melanogaster)
RAC1 [cytosol] (Oryza sativa)
RAC1 [cytosol] (Saccharomyces cerevisiae)
Homologues of RAC1 [cytosol] (Caenorhabditis elegans)
Homologues of RAC1 [cytosol] (Dictyostelium discoideum)
Homologues of RAC1 [cytosol] (Oryza sativa)
Cross References
RefSeq
NP_002863.1
Brenda
3.6.5.2
GeneCards
P15153
DOCK Blaster
2W2T
,
1DS6
,
2W2V
,
2W2X
PRO
P15153
Orphanet
18485
HMDB Protein
HMDBP01788
PDB
1DS6
,
2W2T
,
2W2V
,
2W2X
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [ChEBI:16618]
6
PI(3,4,5)P3 [endocytic vesicle membrane]
(R-ALL-917725)
PIP3 [plasma membrane]
(R-ALL-38117)
PI(3,4,5)P3 [endosome membrane]
(R-ALL-917716)
PI(3,4,5)P3 [early endosome membrane]
(R-ALL-8849955)
PI(3,4,5)P3 [cytoplasmic vesicle membrane]
(R-ALL-8874468)
PI(3,4,5)P3 [plasma membrane]
(R-ALL-179838)
0.462
2
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [ChEBI:18348]
6
PI(4,5)P2 [endoplasmic reticulum membrane]
(R-ALL-2023856)
PI(4,5)P2 [plasma membrane]
(R-ALL-179856)
PI(4,5)P2 [nucleoplasm]
(R-ALL-6810412)
PI(4,5)P2 [Golgi membrane]
(R-ALL-1806165)
PI(4,5)P2 [cytoplasmic vesicle membrane]
(R-ALL-8874467)
PI(4,5)P2 [early endosome membrane]
(R-ALL-8849966)
0.462
2
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate [ChEBI:16851]
7
PI(3,5)P2 [Golgi membrane]
(R-ALL-1806290)
PI(3,5)P2 [plasma membrane]
(R-ALL-1806224)
PI(3,5)P2 [early endosome membrane]
(R-ALL-1806205)
PI(3,5)P2 [late endosome membrane]
(R-ALL-1806289)
PI(3,5)P2 [phagophore assembly site membrane]
(R-ALL-5692959)
PI(3,5)P2 [endoplasmic reticulum membrane]
(R-ALL-6809774)
PI(3,5)P2 [lysosomal membrane]
(R-ALL-5334668)
0.462
2
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