Reactome | RAC2 [cytosol]

RAC2 [cytosol]

Stable Identifier

R-HSA-195343

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Rac2

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Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase cycle (Homo sapiens)
      - RAC2 GTPase cycle (Homo sapiens)
        
        RAC2 GDIs block activation of RAC2 (Homo sapiens)
        
        ARHGDIA:RAC2:GDP [cytosol] (Homo sapiens)
        
        RAC2:GDP [cytosol] (Homo sapiens)
        
        RAC2 [cytosol] (Homo sapiens)
- Signaling by WNT (Homo sapiens)
  - Beta-catenin independent WNT signaling (Homo sapiens)
    - PCP/CE pathway (Homo sapiens)
      - ppDVL recruits RAC (Homo sapiens)
        
        RAC:GTP [cytosol] (Homo sapiens)
        
        RAC [cytosol] (Homo sapiens)
        
        RAC2 [cytosol] (Homo sapiens)
        
        pp-DVL:RAC:GTP [plasma membrane] (Homo sapiens)
        
        RAC:GTP [cytosol] (Homo sapiens)
        
        RAC [cytosol] (Homo sapiens)
        
        RAC2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P15153 RAC2

Gene Names

RAC2

Chain

chain:1-189, propeptide:190-192

Reference Genes

BioGPS Gene:5880 RAC2

COSMIC (genes):RAC2 RAC2

CTD Gene:5880 RAC2

dbSNP Gene:5880 RAC2

ENSEMBL:ENSG00000128340 RAC2

HGNC:9802 RAC2

KEGG Gene (Homo sapiens):5880 RAC2

Monarch:5880 RAC2

NCBI Gene:5880 RAC2

OMIM:602049 RAC2

UCSC:P15153 RAC2

Reference Transcript

RefSeq:NM_002872.4 RAC2

Other Identifiers

0002690095

11744263_s_at

16934749

207419_3p_s_at

207419_s_at

213603_s_at

2989055

32736_at

32737_at

3960062

3960063

3960064

3960065

3960066

3960067

3960069

3960071

3960079

3960080

3960081

5880

8075910

A_23_P218770

A_23_P218774

A_24_P228717

GE80267

GE81848

GO:0000166

GO:0000902

GO:0002376

GO:0003674

GO:0003924

GO:0005515

GO:0005525

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005635

GO:0005737

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0005925

GO:0005938

GO:0006464

GO:0006605

GO:0006810

GO:0006935

GO:0007005

GO:0007010

GO:0007015

GO:0007155

GO:0007163

GO:0007165

GO:0007186

GO:0007264

GO:0008045

GO:0008150

GO:0008283

GO:0008284

GO:0008360

GO:0010310

GO:0010592

GO:0010810

GO:0015031

GO:0016020

GO:0016192

GO:0016601

GO:0019887

GO:0019899

GO:0019901

GO:0022607

GO:0030027

GO:0030031

GO:0030036

GO:0030154

GO:0030234

GO:0030670

GO:0030865

GO:0031410

GO:0032956

GO:0040011

GO:0042129

GO:0042592

GO:0042995

GO:0043167

GO:0043226

GO:0043231

GO:0043304

GO:0043652

GO:0045453

GO:0045454

GO:0045859

GO:0048856

GO:0048870

GO:0051056

GO:0051897

GO:0060263

GO:0060753

GO:0061024

GO:0070062

GO:0071593

GO:0090023

GO:1902622

GO:1903955

HMNXSV003032615

Hs.301175.1.S1_3p_s_at

ILMN_1709795

M64595_at

PH_hs_0015519

TC22000725.hg

Participates

as a component of

RAC2:GDP [cytosol] (Homo sapiens)

as a member of

VAV1 effectors [cytosol] (Homo sapiens)

as a candidate of

RAC [cytosol] (Homo sapiens)

Other forms of this molecule

RAC2 [endoplasmic reticulum membrane]

RAC2 [mitochondrial outer membrane]

RAC2 [phagocytic vesicle membrane]

RAC2 [plasma membrane]

Inferred To

racM [cytosol] (Dictyostelium discoideum)

rac2 [cytosol] (Danio rerio)

racN [cytosol] (Dictyostelium discoideum)

racE [cytosol] (Dictyostelium discoideum)

Homologues of RAC2 [cytosol] (Caenorhabditis elegans)

Homologues of RAC2 [cytosol] (Dictyostelium discoideum)

Homologues of RAC2 [cytosol] (Drosophila melanogaster)

rac-2 [cytosol] (Caenorhabditis elegans)

racC [cytosol] (Dictyostelium discoideum)

racJ [cytosol] (Dictyostelium discoideum)

Rac2 [cytosol] (Drosophila melanogaster)

Rac2 [cytosol] (Mus musculus)

Rac2 [cytosol] (Rattus norvegicus)

racF2 [cytosol] (Dictyostelium discoideum)

rac1C [cytosol] (Dictyostelium discoideum)

racD [cytosol] (Dictyostelium discoideum)

ced-10 [cytosol] (Caenorhabditis elegans)

RAC2 [cytosol] (Bos taurus)

RAC2 [cytosol] (Caenorhabditis elegans)

RAC2 [cytosol] (Canis familiaris)

RAC2 [cytosol] (Dictyostelium discoideum)

RAC2 [cytosol] (Gallus gallus)

RAC2 [cytosol] (Sus scrofa)

RAC2 [cytosol] (Xenopus tropicalis)

rac1B [cytosol] (Dictyostelium discoideum)

racQ [cytosol] (Dictyostelium discoideum)

rac1A [cytosol] (Dictyostelium discoideum)

racF1 [cytosol] (Dictyostelium discoideum)

racH [cytosol] (Dictyostelium discoideum)

racB [cytosol] (Dictyostelium discoideum)

racG [cytosol] (Dictyostelium discoideum)

racL [cytosol] (Dictyostelium discoideum)

RAC1_DROME [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_002863.1

Target Pathogen

5b354852be737e166372e92f

OpenTargets

ENSG00000128340

GeneCards

P15153

HPA

ENSG00000128340-RAC2

Ensembl

ENST00000249071, ENSP00000249071, ENSG00000128340

PRO

P15153

Orphanet

18485

HMDB Protein

HMDBP01788

PDB

2W2V, 2W2T, 1DS6, 2W2X

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P53365 ARFIP2	1	ARFIP2 [cytosol] (R-HSA-6813848)	0.556	3
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate [ChEBI:16851]	7	PI(3,5)P2 [plasma membrane] (R-ALL-1806224) PI(3,5)P2 [phagophore assembly site membrane] (R-ALL-5692959) PI(3,5)P2 [Golgi membrane] (R-ALL-1806290) PI(3,5)P2 [early endosome membrane] (R-ALL-1806205) PI(3,5)P2 [late endosome membrane] (R-ALL-1806289) PI(3,5)P2 [endoplasmic reticulum membrane] (R-ALL-6809774) PI(3,5)P2 [lysosomal membrane] (R-ALL-5334668)	0.462	2
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [ChEBI:16618]	6	PI(3,4,5)P3 [endocytic vesicle membrane] (R-ALL-917725) PIP3 [plasma membrane] (R-ALL-38117) PI(3,4,5)P3 [endosome membrane] (R-ALL-917716) PI(3,4,5)P3 [early endosome membrane] (R-ALL-8849955) PI(3,4,5)P3 [cytoplasmic vesicle membrane] (R-ALL-8874468) PI(3,4,5)P3 [plasma membrane] (R-ALL-179838)	0.462	2
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [ChEBI:18348]	6	PI(4,5)P2 [endoplasmic reticulum membrane] (R-ALL-2023856) PI(4,5)P2 [plasma membrane] (R-ALL-179856) PI(4,5)P2 [Golgi membrane] (R-ALL-1806165) PI(4,5)P2 [nucleoplasm] (R-ALL-6810412) PI(4,5)P2 [cytoplasmic vesicle membrane] (R-ALL-8874467) PI(4,5)P2 [early endosome membrane] (R-ALL-8849966)	0.462	2

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