Reactome | RAC2 [plasma membrane]

RAC2 [plasma membrane]

Stable Identifier

R-HSA-195339

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Rac2

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - PI3K/AKT Signaling in Cancer (Homo sapiens)
    - Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
      - PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
        
        PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Homo sapiens)
        
        RAC1:GTP,RAC2:GTP,RHOG:GTP [plasma membrane] (Homo sapiens)
        
        RAC2:GTP [plasma membrane] (Homo sapiens)
        
        RAC2 [plasma membrane] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Homo sapiens)
        
        RAC1:GTP,RAC2:GTP,RHOG:GTP [plasma membrane] (Homo sapiens)
        
        RAC2:GTP [plasma membrane] (Homo sapiens)
        
        RAC2 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P15153 RAC2

Gene Names

RAC2

Chain

chain:1-189, propeptide:190-192

Reference Genes

BioGPS Gene:5880 RAC2

COSMIC (genes):RAC2 RAC2

CTD Gene:5880 RAC2

dbSNP Gene:5880 RAC2

ENSEMBL:ENSG00000128340 RAC2

HGNC:9802 RAC2

KEGG:hsa:5880 RAC2

Monarch:5880 RAC2

NCBI Gene:5880 RAC2

OMIM:602049 RAC2

UCSC:P15153 RAC2

Reference Transcript

RefSeq:NM_002872.4 RAC2

Other Identifiers

11744263_s_at

16934749

207419_3p_s_at

207419_PM_s_at

207419_s_at

213603_PM_s_at

213603_s_at

2989055

32736_at

32737_at

3960062

3960063

3960064

3960065

3960066

3960067

3960068

3960069

3960070

3960071

3960078

3960079

3960080

3960081

3960082

5880

8075910

A_23_P218770

A_23_P218774

A_24_P228717

A_33_P3220160

GE80267

GE81848

GO:0003824

GO:0003924

GO:0005515

GO:0005525

GO:0005635

GO:0005737

GO:0005741

GO:0005789

GO:0005829

GO:0005884

GO:0005886

GO:0005925

GO:0006935

GO:0007010

GO:0007015

GO:0007155

GO:0007165

GO:0007186

GO:0007264

GO:0008283

GO:0010310

GO:0010592

GO:0010810

GO:0016020

GO:0016787

GO:0019887

GO:0030027

GO:0030031

GO:0030036

GO:0030670

GO:0042129

GO:0043020

GO:0043131

GO:0043226

GO:0043304

GO:0045453

GO:0045730

GO:0060263

GO:0060753

GO:0070062

GO:0070662

GO:0070668

GO:0071593

GO:0090023

GO:0098772

GO:1902622

GO:1903955

HMNXSV003023793

HMNXSV003032615

Hs.301175.1.S1_3p_s_at

ILMN_1709795

M64595_at

PH_hs_0015519

TC22000725.hg

Participates

as a component of

Other forms of this molecule

RAC2 [endoplasmic reticulum membrane]

RAC2 [mitochondrial outer membrane]

RAC2 [phagocytic vesicle membrane]

RAC2 [cytosol]

Inferred To

Homologues of RAC2 [plasma membrane] (Caenorhabditis elegans)

Homologues of RAC2 [plasma membrane] (Dictyostelium discoideum)

Homologues of RAC2 [plasma membrane] (Drosophila melanogaster)

Rac2 [plasma membrane] (Rattus norvegicus)

RAC1 [plasma membrane] (Caenorhabditis elegans)

RAC1 [plasma membrane] (Dictyostelium discoideum)

RAC1 [plasma membrane] (Drosophila melanogaster)

racP [plasma membrane] (Dictyostelium discoideum)

RAC2 [plasma membrane] (Bos taurus)

RAC2 [plasma membrane] (Caenorhabditis elegans)

RAC2 [plasma membrane] (Canis familiaris)

RAC2 [plasma membrane] (Dictyostelium discoideum)

RAC2 [plasma membrane] (Drosophila melanogaster)

RAC2 [plasma membrane] (Gallus gallus)

RAC2 [plasma membrane] (Mus musculus)

RAC2 [plasma membrane] (Sus scrofa)

rac2 [plasma membrane] (Danio rerio)

rac2 [plasma membrane] (Xenopus tropicalis)

racQ [plasma membrane] (Dictyostelium discoideum)

Cross References

RefSeq

NP_002863.1

ENSEMBL

ENSG00000128340, ENST00000249071, ENSP00000249071

OpenTargets

ENSG00000128340

GeneCards

RAC2

HPA

ENSG00000128340-RAC2

PRO

P15153

Pharos - Targets

P15153

GlyGen

P15153

Orphanet

RAC2

HMDB Protein

HMDBP01788

PDB

1DS6, 2W2V, 2W2T, 2W2X

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P53365 ARFIP2	1	ARFIP2 [cytosol] (R-HSA-6813848)	0.556	3
UniProt:P52306 RAP1GDS1	1	RAP1GDS1 [mitochondrial outer membrane] (R-HSA-9693756)	0.527	2