Reactome | SRGAP2 [cytosol]

SRGAP2 [cytosol]

Stable Identifier

R-HSA-195131

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SrGAP2, ARHGAP34

Icon

Locations in the PathwayBrowser for interactor UniProt:Q8N7C3 TRIMM

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External Reference Information

External Reference

UniProt:O75044 SRGAP2

Gene Names

SRGAP2, ARHGAP34, FNBP2, KIAA0456, SRGAP2A

Chain

chain:1-1071

Reference Genes

BioGPS Gene:23380 SRGAP2

COSMIC (genes):SRGAP2 SRGAP2

CTD Gene:23380 SRGAP2

dbSNP Gene:23380 SRGAP2

ENSEMBL:ENSG00000266028 SRGAP2

ENSEMBL_homo_sapiens_GENE:ENSG00000266028.8 SRGAP2

HGNC:19751 SRGAP2

KEGG Gene (Homo sapiens):23380 SRGAP2

Monarch:23380 SRGAP2

NCBI Gene:23380 SRGAP2

OMIM:606524 SRGAP2

UCSC:O75044 SRGAP2

Reference Transcript

Other Identifiers

11719438_at

11719439_at

11719440_at

16676562

16698618

213329_PM_at

213329_at

23380

2376704

2376737

2376739

2376741

2376743

2376747

2376751

2376757

2376759

2376764

2376766

2376768

2376770

2376774

2376776

2376778

2376782

2376792

2376794

2376796

2431727

2431728

2431730

2431732

2431734

2431735

2431737

2431741

2431742

2431755

36069_at

7904469

7904482

7909175

ADDON001107.hg

A_23_P200829

A_32_P50123

A_33_P3372705

GE53197

GO:0003363

GO:0005096

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0007010

GO:0007155

GO:0007165

GO:0007399

GO:0014069

GO:0016020

GO:0021816

GO:0023052

GO:0030027

GO:0030154

GO:0030336

GO:0031267

GO:0031410

GO:0034330

GO:0034446

GO:0042802

GO:0042803

GO:0042995

GO:0043197

GO:0043226

GO:0043547

GO:0044327

GO:0045202

GO:0045211

GO:0045335

GO:0046847

GO:0048812

GO:0048856

GO:0048870

GO:0051014

GO:0051056

GO:0060996

GO:0098772

GO:1904861

GO:1904862

GO:2001223

HMNXSV003006393

HMNXSV003026311

HMNXSV003057573

Hs.5003.0.A1_3p_at

ILMN_1755910

ILMN_1759549

ILMN_1797451

ILMN_2261379

ILMN_2348448

PH_hs_0000513

TC01001050.hg

TC01001074.hg

TC01001721.hg

TC01003055.hg

TC01003757.hg

TC01004674.hg

TC01004687.hg

p28963

Participates

as a candidate of

as a member of

as an input of

SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Homo sapiens)

as an output of

SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Homo sapiens)

as a component of

SRGAP2:RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Homo sapiens)

Inferred To

SRGAP2 [cytosol] (Bos taurus)

SRGAP2 [cytosol] (Canis familiaris)

SRGAP2 [cytosol] (Gallus gallus)

SRGAP2 [cytosol] (Sus scrofa)

srgp-1 [cytosol] (Caenorhabditis elegans)

Srgap2 [cytosol] (Mus musculus)

Srgap2 [cytosol] (Rattus norvegicus)

srgap2 [cytosol] (Danio rerio)

Ghost homologue of SRGAP2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_056141.2, XP_005277567.1, NP_001164108.1

OpenTargets

ENSG00000266028

HPA

ENSG00000266028-SRGAP2

GeneCards

O75044

Ensembl

ENST00000573034, ENSP00000459615, ENSG00000266028

PRO

O75044

Pharos - Targets

O75044

PDB

4RUG, 2DL8, 4RTT, 5I7D, 5I6R, 5I6J

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.867	7
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.816	6
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.802	6
UniProt:O75044 SRGAP2	1	SRGAP2 [cytosol] (R-HSA-195131)	0.74	5
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.706	4
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.706	4
UniProt:O14744 PRMT5	3	p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300) PRMT5 [nucleoplasm] (R-HSA-5205609) PRMT5 [cytosol] (R-HSA-191876)	0.611	4
UniProt:P48023 FASLG	1	FASLG(1-281) [extracellular region] (R-HSA-66212)	0.609	2
UniProt:O95466 FMNL1	1	FMNL1 [cytosol] (R-HSA-5663224)	0.602	3
UniProt:Q9Y6N7 ROBO1	3	p-Y1073-ROBO1 [plasma membrane] (R-HSA-375979) PolyUb-ROBO1 [plasma membrane] (R-HSA-8986095) ROBO1 [plasma membrane] (R-HSA-204361)	0.558	3
UniProt:Q9NRI5 DISC1			0.553	2
UniProt:Q8N7C3 TRIMM			0.527	2
UniProt:Q6ZPF4	1	Fmnl3 [cytosol] (R-MMU-5665760)	0.527	3