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ARHGEF11 [cytosol]
Stable Identifier
R-HSA-195102
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PDZ-RhoGEF
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Semaphorin interactions (Homo sapiens)
Sema4D in semaphorin signaling (Homo sapiens)
Sema4D induced cell migration and growth-cone collapse (Homo sapiens)
Activation of Rho by LARG and PDZ-RhoGEF (Homo sapiens)
ARHGEF11,ARHGEF12 [cytosol] (Homo sapiens)
ARHGEF11 [cytosol] (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1:RND1:ARHGEF11,ARHGEF12 [plasma membrane] (Homo sapiens)
ARHGEF11,ARHGEF12 [cytosol] (Homo sapiens)
ARHGEF11 [cytosol] (Homo sapiens)
LARG and PDZ-RhoGEF binds to Plexin-B1 (Homo sapiens)
ARHGEF11,ARHGEF12 [cytosol] (Homo sapiens)
ARHGEF11 [cytosol] (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1:RND1:ARHGEF11,ARHGEF12 [plasma membrane] (Homo sapiens)
ARHGEF11,ARHGEF12 [cytosol] (Homo sapiens)
ARHGEF11 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRAGE signals death through JNK (Homo sapiens)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
ARHGEF11 [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (12/13) signalling events (Homo sapiens)
GEFs activate RhoA,B,C (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
ARHGEF11 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 GEFs activate CDC42 (Homo sapiens)
CDC42 GEFs [cytosol] (Homo sapiens)
ARHGEF11 [cytosol] (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 GEFs activate RAC1 (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
ARHGEF11 [cytosol] (Homo sapiens)
RHOA GTPase cycle (Homo sapiens)
RHOA GEFs activate RHOA (Homo sapiens)
RHOA GEFs [cytosol] (Homo sapiens)
ARHGEF11 [cytosol] (Homo sapiens)
RHOB GTPase cycle (Homo sapiens)
RHOB GEFs activate RHOB (Homo sapiens)
RHOB GEFs [cytosol] (Homo sapiens)
ARHGEF11 [cytosol] (Homo sapiens)
RHOC GTPase cycle (Homo sapiens)
RHOC GEFs activate RHOC (Homo sapiens)
RHOC GEFs [cytosol] (Homo sapiens)
ARHGEF11 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15085 ARHGEF11
Gene Names
ARHGEF11, KIAA0380
Chain
chain:1-1522
Reference Genes
BioGPS Gene:9826 ARHGEF11
COSMIC (genes):ARHGEF11 ARHGEF11
CTD Gene:9826 ARHGEF11
dbSNP Gene:9826 ARHGEF11
ENSEMBL:ENSG00000132694 ARHGEF11
ENSEMBL_homo_sapiens_GENE:ENSG00000132694.19 ARHGEF11
HGNC:14580 ARHGEF11
KEGG Gene (Homo sapiens):9826 ARHGEF11
Monarch:9826 ARHGEF11
NCBI Gene:9826 ARHGEF11
OMIM:605708 ARHGEF11
UCSC:O15085 ARHGEF11
Reference Transcript
RefSeq:NM_014784.3 ARHGEF11
RefSeq:NM_198236.2 ARHGEF11
Other Identifiers
11722549_a_at
11748607_a_at
11748608_s_at
16694804
202913_PM_at
202913_at
202914_PM_s_at
202914_s_at
2438658
2438659
2438660
2438661
2438662
2438664
2438668
2438670
2438671
2438672
2438674
2438675
2438676
2438677
2438678
2438681
2438682
2438683
2438684
2438685
2438686
2438687
2438688
2438689
2438690
2438691
2438692
2438693
2438694
2438695
2438696
2438697
2438700
2438701
2438702
2438703
2438704
2438705
2438706
2438707
2438708
2438709
2438725
2438726
2438727
39281_at
64412_at
7921179
9826
A_23_P426809
GE53096
GO:0001558
GO:0001664
GO:0003012
GO:0005085
GO:0005096
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006941
GO:0007010
GO:0007163
GO:0007186
GO:0007266
GO:0016020
GO:0023052
GO:0030010
GO:0030036
GO:0043226
GO:0045893
GO:0051056
GO:0098772
HMNXSV003046852
Hs.47822.0.S2_3p_at
Hs.47822.0.S2_3p_x_at
ILMN_1656546
ILMN_1733861
ILMN_2347380
PH_hs_0029908
TC01003356.hg
g7662085_3p_a_at
Participates
as a member of
RHOA GEFs [cytosol] (Homo sapiens)
RHOC GEFs [cytosol] (Homo sapiens)
RHOB GEFs [cytosol] (Homo sapiens)
ARHGEF11,ARHGEF12 [cytosol] (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
as a candidate of
CDC42 GEFs [cytosol] (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
Inferred To
RhoGEF2 [cytosol]
(Drosophila melanogaster)
arhgef11 [cytosol]
(Danio rerio)
arhgef11 [cytosol]
(Xenopus tropicalis)
rhgf-1 [cytosol]
(Caenorhabditis elegans)
ARHGEF11 [cytosol]
(Bos taurus)
ARHGEF11 [cytosol]
(Canis familiaris)
ARHGEF11 [cytosol]
(Gallus gallus)
ARHGEF11 [cytosol]
(Sus scrofa)
Arhgef11 [cytosol]
(Mus musculus)
Arhgef11 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_937879.1
,
NP_055599.1
OpenTargets
ENSG00000132694
GeneCards
O15085
HPA
ENSG00000132694-ARHGEF11
Ensembl
ENSG00000132694
,
ENSP00000354644
,
ENST00000361409
,
ENSP00000357177
,
ENST00000368194
PRO
O15085
Pharos - Targets
O15085
HMDB Protein
HMDBP11486
PDB
3KZ1
,
5JHH
,
1XCG
,
5JHG
,
5TYT
,
5E6P
,
3T06
,
1HTJ
,
2DLS
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61586 RHOA
6
RHOA [ficolin-1-rich granule membrane]
(R-HSA-6804971)
RHOA [secretory granule membrane]
(R-HSA-6804980)
RHOA [endoplasmic reticulum membrane]
(R-HSA-5672082)
RHOA [cytosol]
(R-HSA-194866)
RHOA [cell junction]
(R-HSA-2134503)
RHOA [plasma membrane]
(R-HSA-194510)
0.903
12
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