GAPs inactivate Rho GTPase:GTP by hydrolysis

Stable Identifier
R-HSA-194922
Type
Reaction [transition]
Species
Homo sapiens
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The human genome includes approximately 70 genes that are predicted to encode Rho-specific GTPase Activating Proteins (RhoGAPs). As in the case of GEFs, some RhoGAPs are believed to be highly specific, whereas others are more promiscuous with respect to their target GTPases. Increasing evidence suggests that GAPs are also regulated by external cues in addition to being signal terminators leading to Rho GTPase inactivation. These proteins play important role in many Rho mediated signaling pathways.

Some known GAPs include p190 A, cdGAP, ARAP3, MgcRacGAP, Chimaerin, Nadrin, TCGAP, DLC 1, 2, ArhGAP6, Myosin IXA. These and other GAPs have been implicated in many processes, such as exocytosis, endocytosis, cytokinesis, cell differentiation, migration, neuronal morphogenesis, angiogenesis and tumor suppression.

Literature References
PubMed ID Title Journal Year
11431473 Rich, a rho GTPase-activating protein domain-containing protein involved in signaling by Cdc42 and Rac1

Richnau, N, Aspenstrom, P

J Biol Chem 2001
11804589 Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices

Krugmann, S, Anderson, KE, Ridley, SH, Risso, N, McGregor, A, Coadwell, J, Davidson, K, Eguinoa, A, Ellson, CD, Lipp, P, Manifava, M, Ktistakis, N, Painter, G, Thuring, JW, Cooper, MA, Lim, ZY, Holmes, AB, Dove, SK, Michell, RH, Grewal, A, Nazarian, A, Erdjument-Bromage, H, Tempst, P, Stephens, LR, Hawkins, PT

Mol Cell 2002
17222083 Current knowledge of the large RhoGAP family of proteins

Tcherkezian, J, Lamarche-Vane, N

Biol Cell 2007
9605766 Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP

Yuan, BZ, Miller, MJ, Keck, CL, Zimonjic, DB, Thorgeirsson, SS, Popescu, NC

Cancer Res 1998
8288572 Characterization of rhoGAP. A GTPase-activating protein for rho-related small GTPases.

Lancaster, CA, Taylor-Harris, PM, Self, AJ, Brill, S, van Erp, HE, Hall, A

J Biol Chem 1994
2825022 A new fused transcript in Philadelphia chromosome positive acute lymphocytic leukaemia

Fainstein, E, Marcelle, C, Rosner, A, Canaani, E, Gale, RP, Dreazen, O, Smith, SD, Croce, CM

Nature 1987
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hasEvent
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Catalyst Activity
Title
GTPase activator activity of GAPs [cytosol]
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Orthologous Events
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