Rho GTPase:GTP activates downstream effectors

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Homo sapiens
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To transduce signals, the activated, GTP-bound Rho GTPases interact with specific effector molecules. It has been observed that GEFs contribute to the signaling specificity of their downstream target GTPase via association with scaffolding molecules that link them and the GTPase to specific GTPase effectors (Govek et al., 2005). Some of the effector molecules implicated in actin and microtubule dynamics include diaphanous-related formins, Toca 1, WIP, WASP, Pak, p35/Cdk5, Wave, Nap125, MLCK, MLC, IRSp53.

Literature References
PubMed ID Title Journal Year
12429845 Motility determinants in WASP family proteins

Yarar, D, D'Alessio, JA, Jeng, RL, Welch, MD

Mol Biol Cell 2002
15260990 Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex

Ho, HY, Rohatgi, R, Lebensohn, AM, Le, Ma, Li, J, Gygi, SP, Kirschner, MW

Cell 2004
12423633 Characterization of the interactions between the small GTPase RhoA and its guanine nucleotide exchange factors

Tan, YC, Wu, H, Wang, WN, Zheng, Y, Wang, ZX

Anal Biochem 2002
15611088 Integrin engagement differentially modulates epithelial cell motility by RhoA/ROCK and PAK1

Zhou, H, Kramer, RH

J Biol Chem 2005
9308960 Rho GTPases and signaling networks

Van Aelst, L, D'Souza-Schorey, C

Genes Dev 1997
11130076 IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling

Miki, H, Yamaguchi, H, Suetsugu, S, Takenawa, T

Nature 2000
11157984 Cdc42Hs facilitates cytoskeletal reorganization and neurite outgrowth by localizing the 58-kD insulin receptor substrate to filamentous actin

Govind, S, Kozma, R, Monfries, C, Lim, L, Ahmed, S

J Cell Biol 2001
12504591 The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42

Soltau, M, Richter, D, Kreienkamp, HJ

Mol Cell Neurosci 2002
10360578 Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein

Abdul-Manan, N, Aghazadeh, B, Liu, GA, Majumdar, A, Ouerfelli, O, Siminovitch, KA, Rosen, MK

Nature 1999
15821030 The nucleotide switch in Cdc42 modulates coupling between the GTPase-binding and allosteric equilibria of Wiskott-Aldrich syndrome protein

Leung, DW, Rosen, MK

Proc Natl Acad Sci U S A 2005
11738596 Dbl family guanine nucleotide exchange factors

Zheng, Y

Trends Biochem Sci 2001
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