Botulinum toxin type A light chain (botA LC), in the cytosol of a target cell, catalyzes the removal of a carboxyterminal peptide from synaptosomal-associated protein 25 (SNAP25). botA LC is a zinc metalloprotease (Binz et al. 1994; Schiavo et al. 1993). SNAP25 is associated with the cytosolic face of the target cell plasma membrane where it forms part of a complex required for synaptic vesicle docking and exocytosis. Its cleavage by botulinum toxin blocks synaptic vesicle fusion with the plasma membrane and neurotransmitter release and in vivo leads to a long lasting flaccid paralysis (Sudhof et al, 1993; Sudhof 2004).
Südhof, TC, Niemann, H, Jahn, R, De Camilli, P
Mehta, PP, Schiavo, G, DasGupta, BR, Montecucco, C, Wilson, MC, Santucci, A, Jontes, J, Benfenati, F
Südhof, TC
Südhof, TC, Link, E, Yamasaki, S, Baumeister, A, Niemann, H, Binz, T, Jahn, R, Blasi, J
metalloendopeptidase activity of botA LC:Zn2+ [cytosol]
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