Botulinum toxin type F light chain (botF LC), in the cytosol of a target cell, catalyzes the removal of an aminoterminal peptide from vesicle-associated membrane protein 1 (VAMP1). botF LC is a zinc metalloprotease (Yamasaki et al. 1994). VAMP1 is associated with the cytosolic face of the target cell synaptic vesicle and is required for vesicle docking and exocytosis. Its cleavage by botulinum toxin blocks synaptic vesicle fusion with the plasma membrane and neurotransmitter release (Sudhof et al, 1993; Sudhof 2004).
Südhof, TC, Niemann, H, Jahn, R, De Camilli, P
Südhof, TC
Fykse, EM, Südhof, TC, Roques, B, Link, E, Yamasaki, S, Baumeister, A, Binz, T, Jahn, R, Cornille, F, Blasi, J
metalloendopeptidase activity of botF LC:Zn2+ [cytosol]
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