BoNT/F LC cleaves target cell VAMP1

Stable Identifier
R-HSA-194808
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Clostridium botulinum
Compartment
synaptic vesicle membrane, cytosol
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BoNT/F LC cleaves target cell VAMP1
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Botulinum toxin type F light chain (BoNT/F LC), in the cytosol of a target cell, catalyzes the removal of an aminoterminal peptide from vesicle-associated membrane protein 1 (VAMP1). BoNT/F LC is a zinc metalloprotease (Yamasaki et al. 1994). VAMP1 is associated with the cytosolic face of the target cell synaptic vesicle and is required for vesicle docking and exocytosis. Its cleavage by botulinum toxin blocks synaptic vesicle fusion with the plasma membrane and neurotransmitter release (Sudhof et al, 1993; Sudhof 2004).

Literature References
PubMed ID Title Journal Year
15217342 The synaptic vesicle cycle

Südhof, TC

Annu Rev Neurosci 2004
8402889 Membrane fusion machinery: insights from synaptic proteins

Südhof, TC, De Camilli, P, Niemann, H, Jahn, R

Cell 1993
8175689 Cleavage of members of the synaptobrevin/VAMP family by types D and F botulinal neurotoxins and tetanus toxin

Yamasaki, S, Baumeister, A, Binz, T, Blasi, J, Link, E, Cornille, F, Roques, B, Fykse, EM, Südhof, TC, Jahn, R

J Biol Chem 1994
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
metalloendopeptidase activity of BoNT/F LC:Zn2+ [cytosol]
Physical Entity
BoNT/F LC:Zn2+ [cytosol]
Activity
metalloendopeptidase activity (0004222)
Disease
Name Identifier Synonyms
botulism 11976 Botulism (disorder), Intoxication with Clostridium botulinum toxin, Botulism, Infection due to clostridium botulinum, Botulism, Foodborne botulism, botulism, Botulism, Botulism, Botulism, Food poisoning due to Clostridium botulinum, Botulism poisoning
Authored
Krupa, S  (2006-06-15)
Gopinathrao, G  (2006-06-15)
Reviewed
Ichtchenko, K  (2007-08-03)
Thirunavukkarasu, N  (2014-11-18)
Sharma, S  (2014-11-18)
Created
Gopinathrao, G  (2007-03-27)
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