Reactome | RHOA [plasma membrane]

RHOA [plasma membrane]

Stable Identifier

R-HSA-194510

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

RhoA, Transforming protein RhoA, RHOA_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:Q92974 ARHGEF2

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External Reference Information

External Reference

UniProt:P61586 RHOA

Gene Names

RHOA, ARH12, ARHA, RHO12

Chain

chain:1-190, propeptide:191-193

Reference Genes

BioGPS Gene:387 RHOA

COSMIC (genes):RHOA RHOA

CTD Gene:387 RHOA

dbSNP Gene:387 RHOA

ENSEMBL:ENSG00000067560 RHOA

ENSEMBL_homo_sapiens_GENE:ENSG00000067560.14 RHOA

HGNC:667 RHOA

KEGG Gene (Homo sapiens):387 RHOA

Monarch:387 RHOA

NCBI Gene:387 RHOA

OMIM:165390 RHOA

UCSC:P61586 RHOA

Reference Transcript

Other Identifiers

11743726_s_at

11753410_a_at

11754043_a_at

11757012_x_at

1394_at

1555814_PM_a_at

1555814_a_at

16954055

18670076

18670077

18670078

18670080

18670081

18670082

18670083

200059_PM_s_at

200059_s_at

2674238

2674239

2674240

2674241

2674243

2674244

2674245

2674246

2674247

2674248

2674249

2674252

2674253

2674255

2674258

2674263

2674265

2674266

2965039

37309_at

387

4000056

4000064

7892846

7893424

7893647

7893815

7894083

7895551

7895657

7896138

7896438

8087409

A_23_P69491

A_23_P69493

A_33_P3364661

GE79565

GO:0000166

GO:0000278

GO:0000902

GO:0000910

GO:0001764

GO:0001822

GO:0001998

GO:0002363

GO:0002376

GO:0003012

GO:0003013

GO:0003014

GO:0003100

GO:0003189

GO:0003824

GO:0003924

GO:0003925

GO:0005515

GO:0005525

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005768

GO:0005783

GO:0005789

GO:0005829

GO:0005856

GO:0005886

GO:0005925

GO:0005938

GO:0006091

GO:0006351

GO:0006355

GO:0006357

GO:0007010

GO:0007049

GO:0007059

GO:0007155

GO:0007160

GO:0007163

GO:0007264

GO:0007266

GO:0007519

GO:0008092

GO:0009898

GO:0010812

GO:0010975

GO:0012501

GO:0016020

GO:0016477

GO:0016787

GO:0017022

GO:0019901

GO:0021762

GO:0021795

GO:0021861

GO:0023052

GO:0030027

GO:0030036

GO:0030054

GO:0030154

GO:0030334

GO:0030425

GO:0030496

GO:0030521

GO:0030667

GO:0031122

GO:0031410

GO:0031982

GO:0032154

GO:0032467

GO:0032587

GO:0032956

GO:0033144

GO:0033688

GO:0034329

GO:0034330

GO:0034446

GO:0035385

GO:0036089

GO:0036211

GO:0038027

GO:0042060

GO:0042476

GO:0042995

GO:0043123

GO:0043149

GO:0043197

GO:0043226

GO:0043296

GO:0043297

GO:0043366

GO:0043542

GO:0043931

GO:0044319

GO:0045198

GO:0045666

GO:0045792

GO:0046638

GO:0048856

GO:0048870

GO:0050886

GO:0050919

GO:0051301

GO:0051496

GO:0051893

GO:0060071

GO:0060193

GO:0061024

GO:0061430

GO:0065003

GO:0070062

GO:0070507

GO:0071222

GO:0071345

GO:0071526

GO:0071803

GO:0071902

GO:0071944

GO:0090051

GO:0090307

GO:0090324

GO:0097049

GO:0097498

GO:0098772

GO:0098794

GO:0098978

GO:0099159

GO:0101003

GO:0140014

GO:1901224

GO:1902766

GO:1903427

GO:1903673

GO:1904695

GO:1904996

GO:1905274

GO:1990869

GO:2000177

GO:2000406

GO:2000672

HMNXSV003035016

HMNXSV003057650

Hs2.77273.2.S1_3p_s_at

ILMN_1781290

L25080_at

PH_hs_0004452

TC03001408.hg

Participates

as a component of

as a member of

as an input of

PIP3 binds to RhoA and activates it (Homo sapiens)

Other forms of this molecule

RHOA [ficolin-1-rich granule membrane]

RHOA [secretory granule membrane]

RHOA [endoplasmic reticulum membrane]

RHOA [cytosol]

RHOA [cell junction]

Inferred To

RHOA [plasma membrane] (Bos taurus)

RHOA [plasma membrane] (Caenorhabditis elegans)

RHOA [plasma membrane] (Canis familiaris)

RHOA [plasma membrane] (Danio rerio)

RHOA [plasma membrane] (Drosophila melanogaster)

RHOA [plasma membrane] (Rattus norvegicus)

RHOA [plasma membrane] (Saccharomyces cerevisiae)

RHOA [plasma membrane] (Schizosaccharomyces pombe)

RHOA [plasma membrane] (Sus scrofa)

cRhoA [plasma membrane] (Gallus gallus)

Rhoa [plasma membrane] (Mus musculus)

rhoc [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001300870.1, NP_001655.1

OpenTargets

ENSG00000067560

ZINC - Substances

RHOA_HUMAN

ZINC target

P61586

PRO

P61586

PDB

7G8O, 7G8Y, 7G84, 7G8N, 5IRC, 7WZA, 3LW8, 7G9D, 7QTM, 3MSX, 1FTN, 7WZC, 5M70, 7G88, 4XOI, 7G8T, 5JHG, 5JHH, 7G8U, 7G8X, 7G99, 7G8D, 1TX4, 7G8P, 7G9B, 7G8E, 6KX2, 5C4M, 7G87, 7G9C, 7G8Q, 7G8H, 7G94, 8FC7, 7G93, 8GI6, 5FR1, 7G8I, 4XSH, 8GI3, 6V6M, 7G81, 7G8L, 3LWN, 6V6U, 7G97, 7G82, 1OW3, 8FCB, 7G8C, 1S1C, 7G8M, 7G8B, 7G9A, 7G90, 5C2K, 7G8Z, 5JCP, 4XH9, 5M6X, 6KX3, 7G9F, 7G8S, 5HPY, 1DPF, 1CXZ, 7G9E, 5ZHX, 7G8R, 1KMQ, 1X86, 5FR2, 1XCG, 7G9J, 7G8W, 7G98, 5A0F, 7G9I, 7G8V, 7G8A, 8BNT, 5BWM, 7G85, 7G86, 3LXR, 6BCB, 7G91, 6R3V, 1LB1, 2RGN, 7G8G, 7G8F, 8FC9, 5EZ6, 1CC0, 7G92, 1A2B, 4XSG, 7G9G, 7QSC, 7G95, 7G89, 8T1C, 7G8K, 3T06, 7G80, 7G9H, 6BC0, 7G8J, 7G96, 6V6V, 7G83, 4D0N, 3KZ1, 6BCA

IntEnz

3.6.5.2

GeneCards

P61586

HPA

ENSG00000067560-RHOA

Ensembl

ENSP00000503282, ENSP00000400175, ENST00000418115, ENSG00000067560, ENST00000678200, ENSP00000408402, ENST00000445425, ENST00000679208, ENSP00000504180

Pharos - Targets

P61586

Orphanet

25605

ZINC - Predictions - Purchasable

RHOA_HUMAN

HMDB Protein

HMDBP01959

Interactors (49)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BST9 RTKN	1	RTKN [cytosol] (R-HSA-5666184)	0.912	9
UniProt:O15085 ARHGEF11	1	ARHGEF11 [cytosol] (R-HSA-195102)	0.903	12
UniProt:P52565 ARHGDIA	1	ARHGDIA [cytosol] (R-HSA-194478)	0.861	7
UniProt:Q9Y4D1 DAAM1	1	DAAM1 [cytosol] (R-HSA-351052)	0.831	10
UniProt:P52306 RAP1GDS1	1	RAP1GDS1 [mitochondrial outer membrane] (R-HSA-9693756)	0.788	7
UniProt:Q8C6B2 Rtkn	2	Rtkn [cytosol] (R-MMU-5666187) Rtkn [cytosol] (R-MMU-5666184)	0.778	4
UniProt:Q9NZN5 ARHGEF12	1	ARHGEF12 [cytosol] (R-HSA-416560)	0.77	4
UniProt:Q92974 ARHGEF2	1	ARHGEF2 [cytosol] (R-HSA-195101)	0.742	5
UniProt:A0A0F6B1Q8 A0A0F6B1Q8			0.737	10
UniProt:P08134 RHOC	3	RHOC [plasma membrane] (R-HSA-194870) RHOC [cytosol] (R-HSA-194853) RHOC [endoplasmic reticulum membrane] (R-HSA-9714362)	0.725	5
UniProt:Q07960 ARHGAP1	1	ARHGAP1 [cytosol] (R-HSA-195193)	0.692	3
UniProt:Q6PDM6 Q6PDM6			0.667	3
UniProt:Q96MK2 RIPR3			0.666	4
UniProt:Q9Y4F9 FAM65B	1	RIPOR2 [cytosol] (R-HSA-9672334)	0.666	4
UniProt:Q13464 ROCK1	6	ROCK1 [extracellular region] (R-HSA-6806527) ROCK1 [secretory granule lumen] (R-HSA-6804967) Activated ROCK1 [cytosol] (R-HSA-4687777) ROCK1(1114-1354) [cytosol] (R-HSA-212524) ROCK1(1-1113) [cytosol] (R-HSA-212523) ROCK1 [cytosol] (R-HSA-212509)	0.656	4
UniProt:P10619 CTSA	7	CTSA(29-480) [lysosomal lumen] (R-HSA-1181230) CTSA(29-326) [extracellular region] (R-HSA-6806187) CTSA(327-480) [extracellular region] (R-HSA-6806233) CTSA(29-326) [azurophil granule lumen] (R-HSA-6799135) CTSA(327-480) [azurophil granule lumen] (R-HSA-6799120) CTSA(29-326) [lysosomal lumen] (R-HSA-1605735) CTSA(327-480) [lysosomal lumen] (R-HSA-1605642)	0.643	4
UniProt:Q6P5Z2 PKN3	2	p-T718-PKN3 [cytosol] (R-HSA-5623654) PKN3 [cytosol] (R-HSA-5623611)	0.643	4
UniProt:Q16513 PKN2	2	p-T816-PKN2 [cytosol] (R-HSA-5623652) PKN2 [cytosol] (R-HSA-5623612)	0.643	4
UniProt:O60610 DIAPH1	4	DIAPH1 [ficolin-1-rich granule membrane] (R-HSA-6801388) DIAPH1 [plasma membrane] (R-HSA-6801557) DIAPH1 [secretory granule membrane] (R-HSA-6801368) DIAPH1 [cytosol] (R-HSA-5665970)	0.602	3
UniProt:Q12774 ARHGEF5	1	ARHGEF5 [cytosol] (R-HSA-8873909)	0.564	2
UniProt:Q7Z6G8-3 ANKS1B			0.556	3
UniProt:Q9Y4F9-2 RIPOR2			0.556	3
UniProt:Q15654 TRIP6			0.556	3
UniProt:Q9UKT9 IKZF3			0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q9HCE7-2 SMURF1			0.544	2
UniProt:P46527 CDKN1B	8	p-S10 CDKN1B [cytosol] (R-HSA-9632829) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-T157-CDKN1B [cytosol] (R-HSA-198629) CDKN1B [cytosol] (R-HSA-198622) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) CDKN1B [nucleoplasm] (R-HSA-182563)	0.544	3
UniProt:Q9Y2M5 KLHL20	1	KLHL20 [cytosol] (R-HSA-976032)	0.527	2
UniProt:Q9NQW7 XPP1			0.527	3
UniProt:Q92888 ARHGEF1	1	ARHGEF1 [cytosol] (R-HSA-114526)	0.527	2
UniProt:P0DTD1-PRO_0000449625 REP			0.527	2
UniProt:P16278 GLB1	8	GLB1 W509C [lysosomal lumen] (R-HSA-2262732) GLB1 Y83C [lysosomal lumen] (R-HSA-2262735) GLB1 R482C [lysosomal lumen] (R-HSA-2262739) GLB1 W273L [lysosomal lumen] (R-HSA-2262738) GLB1 [ficolin-1-rich granule lumen] (R-HSA-6800968) GLB1 [lysosomal lumen] (R-HSA-1605623) GLB1 [azurophil granule lumen] (R-HSA-6799124) GLB1 [extracellular region] (R-HSA-6806213)	0.527	2
UniProt:Q9Y3L5 RAP2C	2	RAP2C [plasma membrane] (R-HSA-6804983) RAP2C [tertiary granule membrane] (R-HSA-6804975)	0.527	2
UniProt:Q9FD10 SSEJ			0.527	3
UniProt:Q4LDG9 DNAL1			0.527	2
UniProt:Q9Y3Q8 T22D4			0.527	3
UniProt:Q6NXR0 IIGP5			0.527	2
UniProt:Q5HYI8 RABL3			0.527	2
UniProt:P02675 FGB	5	FGB(31-491) [platelet alpha granule lumen] (R-HSA-140921) FGB(31-491) [extracellular region] (R-HSA-140846) FGB [plasma membrane] (R-HSA-140917) FGB(31-44) [extracellular region] (R-HSA-140876) FGB [extracellular region] (R-HSA-140584)	0.527	2
UniProt:P51884 LUM	12	LUM [extracellular region] (R-HSA-2466189) N-glycan LUM [Golgi lumen] (R-HSA-2046297) Gal-glycan LUM [Golgi lumen] (R-HSA-2046248) Keratan(1)-LUM [Golgi lumen] (R-HSA-2046316) Keratan(2)-LUM [Golgi lumen] (R-HSA-2046233) Keratan(3)-LUM [Golgi lumen] (R-HSA-2046198) Keratan(4)-LUM [Golgi lumen] (R-HSA-2046205) KS(1)-LUM [Golgi lumen] (R-HSA-2046161) KS(2)-LUM [Golgi lumen] (R-HSA-2046249) KS(2)-LUM [extracellular region] (R-HSA-2046202) KS(2)-LUM [lysosomal lumen] (R-HSA-2046283) LUM [lysosomal lumen] (R-HSA-2104998)	0.527	2
UniProt:P25963 NFKBIA	9	PolyUb-NFKBIA [cytosol] (R-HSA-6782960) NFKBIA [cytosol] (R-HSA-168151) p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) NFKBIA [nucleoplasm] (R-HSA-4656929) monoSUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935) NFKBIA S32I [cytosol] (R-HSA-5228846) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA M37K [cytosol] (R-HSA-5228805)	0.527	2
UniProt:Q15796 SMAD2	20	Ub-SMAD2 [cytosol] (R-HSA-6782774) p-S465,S467-SMAD2 P305L [cytosol] (R-HSA-3315471) p-S465,S467-SMAD2 D300A [cytosol] (R-HSA-3315064) p-S465,S467-SMAD2 D300N [cytosol] (R-HSA-3315066) p-S465,S467-SMAD2 A354T [cytosol] (R-HSA-3315474) p-S465,S467-SMAD2 P305Q [cytosol] (R-HSA-3315070) p-S465,S467-SMAD2 D300V [cytosol] (R-HSA-3315067) SMAD2 S464* [cytosol] (R-HSA-3304362) SMAD2 W422* [cytosol] (R-HSA-9668736) SMAD2 S308* [cytosol] (R-HSA-9668732) SMAD2 R427* [cytosol] (R-HSA-9668733) SMAD2 W448* [cytosol] (R-HSA-9668734) SMAD2 S464L [cytosol] (R-HSA-3304383) SMAD2 C463* [cytosol] (R-HSA-9668735) SMAD2 R321* [cytosol] (R-HSA-9668728) SMAD2 S296* [cytosol] (R-HSA-9668729) SMAD2 S306* [cytosol] (R-HSA-9668730) SMAD2 Q455* [cytosol] (R-HSA-9668731) SMAD2 E439* [cytosol] (R-HSA-9668724) SMAD2 L315* [cytosol] (R-HSA-9668725)	0.524	2
UniProt:P01116 KRAS	20	S-Farn-Me-PalmS KRAS [plasma membrane] (R-HSA-9674814) p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane] (R-HSA-9674821) KRAS A146T [plasma membrane] (R-HSA-9649623) KRAS K147E [plasma membrane] (R-HSA-9651169) KRAS K147T [plasma membrane] (R-HSA-9651180) KRAS V14G [plasma membrane] (R-HSA-9651295) KRAS K147N [plasma membrane] (R-HSA-9651177) KRAS A146V [plasma membrane] (R-HSA-9649626) KRAS A146S [plasma membrane] (R-HSA-9649621) KRAS A146P [plasma membrane] (R-HSA-9649617) KRAS P34R [plasma membrane] (R-HSA-9651276) KRAS P34L [plasma membrane] (R-HSA-9651269) KRAS G12A [plasma membrane] (R-HSA-9649088) KRAS G12R [plasma membrane] (R-HSA-9649090) KRAS G13V [plasma membrane] (R-HSA-9649644) KRAS G13S [plasma membrane] (R-HSA-9649642) KRAS G13C [plasma membrane] (R-HSA-9649636) KRAS G13R [plasma membrane] (R-HSA-9649639) KRAS G13A [plasma membrane] (R-HSA-9649632) KRAS K5N [plasma membrane] (R-HSA-9651361)	0.519	2
UniProt:O08808	4	Diaph1 [ficolin-1-rich granule membrane] (R-MMU-6801388) Diaph1 [plasma membrane] (R-MMU-6801557) Diaph1 [secretory granule membrane] (R-MMU-6801368) Diaph1 [cytosol] (R-MMU-5665970)	0.508	3
UniProt:Q9Z0S9 PRAF1			0.508	2
UniProt:Q6WCQ1 MPRIP	2	MPRIP(2-1015)-RAF1(279-648) fusion [cytosol] (R-HSA-6802406) MPRIP(2-1015)-p-RAF1(279-648) fusion [cytosol] (R-HSA-6802540)	0.499	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	5
UniProt:Q969H4 CNKSR1	1	CNKSR1 [cytosol] (R-HSA-5672629)	0.471	4
UniProt:P19338 NCL	3	NCL [plasma membrane] (R-HSA-9836466) NCL [macropinosome membrane] (R-HSA-9837666) NCL [nucleoplasm] (R-HSA-6791213)	0.463	3

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