Reactome | SMPD2 [plasma membrane]

SMPD2 [plasma membrane]

Stable Identifier

R-HSA-194337

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Sphingomyelin phosphodiesterase 2, NSMA_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:Q14973 SLC10A1

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External Reference Information

External Reference

UniProt:O60906 SMPD2

Gene Names

SMPD2

Chain

chain:1-423

Reference Genes

BioGPS Gene:6610 SMPD2

COSMIC (genes):SMPD2 SMPD2

CTD Gene:6610 SMPD2

dbSNP Gene:6610 SMPD2

ENSEMBL:ENSG00000135587 SMPD2

HGNC:11121 SMPD2

KEGG Gene (Homo sapiens):6610 SMPD2

Monarch:6610 SMPD2

NCBI Gene:6610 SMPD2

OMIM:603498 SMPD2

UCSC:O60906 SMPD2

Reference Transcript

RefSeq:NM_003080.2 SMPD2

Other Identifiers

0002640114

11723772_at

17011572

205622_at

2920917

2920918

2920919

2920920

2920922

2920924

2920925

2920927

2920928

2920930

2920931

2920932

2920934

2920935

2920936

41798_at

6610

8121418

A_14_P117845

A_23_P82162

GE55239

GO:0003674

GO:0004767

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005783

GO:0005886

GO:0005887

GO:0005901

GO:0006629

GO:0006665

GO:0006684

GO:0006685

GO:0006687

GO:0007165

GO:0008150

GO:0009056

GO:0009058

GO:0009612

GO:0016020

GO:0016021

GO:0016787

GO:0030149

GO:0034641

GO:0035556

GO:0043167

GO:0043226

GO:0046513

GO:0046872

GO:0071944

GO:2000304

ILMN_1672176

PH_hs_0027128

TC06000876.hg

g4507094_3p_at

Participant Of

input

Sphingomyelinase is activated by the NGF:p75NTR complex

hasComponent

Active N-SMase:Mg2+ [plasma membrane]

hasMember

SMPD2,3 [plasma membrane]

Inferred To

smpd2b [plasma membrane] (Danio rerio)

Smpd2 [plasma membrane] (Mus musculus)

Smpd2 [plasma membrane] (Rattus norvegicus)

SMPD2 [plasma membrane] (Bos taurus)

SMPD2 [plasma membrane] (Caenorhabditis elegans)

SMPD2 [plasma membrane] (Canis familiaris)

SMPD2 [plasma membrane] (Gallus gallus)

SMPD2 [plasma membrane] (Sus scrofa)

css1 [plasma membrane] (Schizosaccharomyces pombe)

smpd2 [plasma membrane] (Xenopus tropicalis)

nSMase [plasma membrane] (Drosophila melanogaster)

ISC1 [plasma membrane] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_003071.2

OpenTargets

ENSG00000135587

ZINC - Substances

NSMA_HUMAN

GeneCards

O60906

HPA

ENSG00000135587-SMPD2

Ensembl

ENSG00000135587, ENST00000258052, ENSP00000258052

ZINC target

O60906

PRO

O60906

ZINC - Predictions - Purchasable

NSMA_HUMAN

HMDB Protein

HMDBP01090

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y371 SHLB1			0.556	3
IntAct:EBI-22326698 CCSB ORF ID			0.556	3
UniProt:Q9ULP0-2 NDRG4			0.556	3
UniProt:Q9UKF7-2 PITPNC1			0.556	3
UniProt:Q05329 GAD2	2	PXLP-K396-GAD2 [plasma membrane] (R-HSA-936509) PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888582)	0.556	3
UniProt:O00622 CCN1	2	CYR61 [endoplasmic reticulum lumen] (R-HSA-5173201) p-CYR61 [endoplasmic reticulum lumen] (R-HSA-8956919)	0.556	3
UniProt:O15173 PGRC2			0.556	3
UniProt:P49675 STAR	1	STAR [mitochondrial intermembrane space] (R-HSA-196120)	0.556	3
UniProt:Q9UHI5 SLC7A8	1	SLC7A8 [plasma membrane] (R-HSA-352156)	0.556	3
UniProt:Q96AL5 Q96AL5			0.556	3
UniProt:Q9NRX6 KISHB			0.556	3
UniProt:Q8NI60 COQ8A			0.556	3
UniProt:P53367 ARFP1			0.556	3
UniProt:Q9NUH8 TM14B			0.556	3
UniProt:Q14973 SLC10A1	1	SLC10A1 [plasma membrane] (R-HSA-194116)	0.556	3

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