VEGF-C,D bind to VEGFR3 leading to receptor dimerization

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R-HSA-194308
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Reaction
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Homo sapiens
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VEGFR-3 preferentially binds VEGF-C and -D. Mutations of the VEGFR-3 tyrosine kinase domain are seen in human lymphedema. VEGFR-3 expression has been correlated with transient lymphangiogenesis in wound healing and may modulate VEGFR-2 signaling in maintaining vascular integrity (Hicklin and Ellis 2005).

Literature References
PubMed ID Title Journal Year
8700872 Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4

Avraham, H, Luoh, SM, Yuan, J, Wood, WI, Gray, A, Lee, J

Proc Natl Acad Sci U S A 1996
11532940 Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3

Achen, MG, Veikkola, T, Makinen, T, Mustjoki, S, Kerjaschki, D, Nice, EC, Alitalo, K, Kowalski, H, Catimel, B, Wise, L, Karpanen, T, Stacker, SA, Mercer, A

EMBO J 2001
9435229 Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)

Wilks, AF, Alitalo, K, Achen, MG, Kukk, E, Makinen, T, Jeltsch, M, Vitali, A, Stacker, SA

Proc Natl Acad Sci U S A 1998
8617204 A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases

Kalkkinen, N, Lahtinen, I, Alitalo, K, Kaipainen, A, Kukk, E, Chilov, D, Pajusola, K, Saksela, O, Joukov, V

EMBO J 1996
12881528 Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites

Alitalo, K, Karkkainen, MJ, Wirzenius, M, Makinen, T, Dixelius, J, Claesson-Welsh, L, Wernstedt, C

J Biol Chem 2003
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