VEGFR-3 preferentially binds VEGF-C and -D. Mutations of the VEGFR-3 tyrosine kinase domain are seen in human lymphedema. VEGFR-3 expression has been correlated with transient lymphangiogenesis in wound healing and may modulate VEGFR-2 signaling in maintaining vascular integrity (Hicklin and Ellis 2005).
Avraham, H, Luoh, SM, Yuan, J, Wood, WI, Gray, A, Lee, J
Achen, MG, Veikkola, T, Makinen, T, Mustjoki, S, Kerjaschki, D, Nice, EC, Alitalo, K, Kowalski, H, Catimel, B, Wise, L, Karpanen, T, Stacker, SA, Mercer, A
Wilks, AF, Alitalo, K, Achen, MG, Kukk, E, Makinen, T, Jeltsch, M, Vitali, A, Stacker, SA
Kalkkinen, N, Lahtinen, I, Alitalo, K, Kaipainen, A, Kukk, E, Chilov, D, Pajusola, K, Saksela, O, Joukov, V
Alitalo, K, Karkkainen, MJ, Wirzenius, M, Makinen, T, Dixelius, J, Claesson-Welsh, L, Wernstedt, C
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