Reactome | VEGF-C,D bind to VEGFR3 leading to receptor dimerization

VEGF-C,D bind to VEGFR3 leading to receptor dimerization

Stable Identifier

R-HSA-194308

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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VEGF-C,D bind to VEGFR3 leading to receptor dimerization

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VEGFR-3 preferentially binds VEGF-C and -D. Mutations of the VEGFR-3 tyrosine kinase domain are seen in human lymphedema. VEGFR-3 expression has been correlated with transient lymphangiogenesis in wound healing and may modulate VEGFR-2 signaling in maintaining vascular integrity (Hicklin and Ellis 2005).

Literature References

PubMed ID	Title	Journal	Year
8700872	Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4 Avraham, H, Luoh, SM, Yuan, J, Wood, WI, Gray, A, Lee, J	Proc Natl Acad Sci U S A	1996
11532940	Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3 Achen, MG, Veikkola, T, Makinen, T, Mustjoki, S, Kerjaschki, D, Nice, EC, Alitalo, K, Kowalski, H, Catimel, B, Wise, L, Karpanen, T, Stacker, SA, Mercer, A	EMBO J	2001
9435229	Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4) Wilks, AF, Alitalo, K, Achen, MG, Kukk, E, Makinen, T, Jeltsch, M, Vitali, A, Stacker, SA	Proc Natl Acad Sci U S A	1998
8617204	A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases Kalkkinen, N, Lahtinen, I, Alitalo, K, Kaipainen, A, Kukk, E, Chilov, D, Pajusola, K, Saksela, O, Joukov, V	EMBO J	1996
12881528	Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites Alitalo, K, Karkkainen, MJ, Wirzenius, M, Makinen, T, Dixelius, J, Claesson-Welsh, L, Wernstedt, C	J Biol Chem	2003