Reactome | VEGF-C,D bind to VEGFR3 leading to receptor dimerization

VEGF-C,D bind to VEGFR3 leading to receptor dimerization

Stable Identifier

R-HSA-194308

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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VEGF-C,D bind to VEGFR3 leading to receptor dimerization

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VEGFR-3 preferentially binds VEGF-C and -D. Mutations of the VEGFR-3 tyrosine kinase domain are seen in human lymphedema. VEGFR-3 expression has been correlated with transient lymphangiogenesis in wound healing and may modulate VEGFR-2 signaling in maintaining vascular integrity (Hicklin and Ellis 2005).

Literature References

PubMed ID	Title	Journal	Year
8700872	Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4 Lee, J, Gray, A, Yuan, J, Luoh, SM, Avraham, H, Wood, WI	Proc Natl Acad Sci U S A	1996
11532940	Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3 Makinen, T, Veikkola, T, Mustjoki, S, Karpanen, T, Catimel, B, Nice, EC, Wise, L, Mercer, A, Kowalski, H, Kerjaschki, D, Stacker, SA, Achen, MG, Alitalo, K	EMBO J	2001
9435229	Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4) Achen, MG, Jeltsch, M, Kukk, E, Makinen, T, Vitali, A, Wilks, AF, Alitalo, K, Stacker, SA	Proc Natl Acad Sci U S A	1998
8617204	A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases Joukov, V, Pajusola, K, Kaipainen, A, Chilov, D, Lahtinen, I, Kukk, E, Saksela, O, Kalkkinen, N, Alitalo, K	EMBO J	1996
12881528	Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites Dixelius, J, Makinen, T, Wirzenius, M, Karkkainen, MJ, Wernstedt, C, Alitalo, K, Claesson-Welsh, L	J Biol Chem	2003