VEGFR-3 preferentially binds VEGF-C and -D. Mutations of the VEGFR-3 tyrosine kinase domain are seen in human lymphedema. VEGFR-3 expression has been correlated with transient lymphangiogenesis in wound healing and may modulate VEGFR-2 signaling in maintaining vascular integrity (Hicklin and Ellis 2005).
Makinen, T, Veikkola, T, Mustjoki, S, Karpanen, T, Catimel, B, Nice, EC, Wise, L, Mercer, A, Kowalski, H, Kerjaschki, D, Stacker, SA, Achen, MG, Alitalo, K
Lee, J, Gray, A, Yuan, J, Luoh, SM, Avraham, H, Wood, WI
Achen, MG, Jeltsch, M, Kukk, E, Makinen, T, Vitali, A, Wilks, AF, Alitalo, K, Stacker, SA
Joukov, V, Pajusola, K, Kaipainen, A, Chilov, D, Lahtinen, I, Kukk, E, Saksela, O, Kalkkinen, N, Alitalo, K
Dixelius, J, Makinen, T, Wirzenius, M, Karkkainen, MJ, Wernstedt, C, Alitalo, K, Claesson-Welsh, L
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