Neurophilin interactions with VEGF and VEGFR

Stable Identifier
R-HSA-194306
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Neurophilin interactions with VEGF and VEGFR
Click the image above or here to open this pathway in the Pathway Browser
The plasma membrane-associated Neuropilin receptors NRP-1 and -2 bind some of the VEGF proteins and associate with VEGF receptor proteins. NRP-1 binds VEGF-A165, -B, and PLGF-2; NRP-2 also binds VEGF-A165 and PLGF-2, as well as VEGF-A145 and -C. The Neurolipin receptors appear to act as cofactors for the VEGF receptors, increasing their affinities for specific VEGF ligands, although the importance of this function in vivo remains unclear (Neufeld et al. 2002).
Literature References
PubMed ID Title Journal Year
12613545 The interaction of Neuropilin-1 and Neuropilin-2 with tyrosine-kinase receptors for VEGF

Herzog, Y, Kessler, O, Neufeld, G

Adv Exp Med Biol 2002
Participants
Events
Participates
as an event of
Orthologous Events
Neurophilin interactions with VEGF and VEGFR (Bos taurus)
Neurophilin interactions with VEGF and VEGFR (Canis familiaris)
Neurophilin interactions with VEGF and VEGFR (Danio rerio)
Neurophilin interactions with VEGF and VEGFR (Gallus gallus)
Neurophilin interactions with VEGF and VEGFR (Mus musculus)
Neurophilin interactions with VEGF and VEGFR (Rattus norvegicus)
Neurophilin interactions with VEGF and VEGFR (Sus scrofa)
Neurophilin interactions with VEGF and VEGFR (Xenopus tropicalis)
Authored
Garapati, P V  (2013-08-30)
Reviewed
Claesson-Welsh, L  (2008-02-28)
Created
Gopinathrao, G  (2007-03-12)
Cite Us!