Reactome | LCAT [extracellular region]

LCAT [extracellular region]

Stable Identifier

R-HSA-194239

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Lecithin-cholesterol acyltransferase

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P04180 LCAT

Gene Names

LCAT

Chain

signal peptide:1-24, chain:25-440

Reference Genes

BioGPS Gene:3931 LCAT

COSMIC (genes):LCAT LCAT

CTD Gene:3931 LCAT

dbSNP Gene:3931 LCAT

ENSEMBL:ENSG00000213398 LCAT

ENSEMBL:ENSG00000213398.8 LCAT

HGNC:6522 LCAT

KEGG Gene (Homo sapiens):3931 LCAT

Monarch:3931 LCAT

NCBI Gene:3931 LCAT

OMIM:606967 LCAT

UCSC:P04180 LCAT

Reference Transcript

RefSeq:NM_000229.1 LCAT

Other Identifiers

11725886_a_at

16827494

204428_PM_s_at

204428_s_at

35118_at

3696036

3696037

3696038

3696039

3696046

3696047

3696049

3696050

3696054

3931

63682_f_at

8002143

A_23_P218237

GE79173

GO:0003824

GO:0003847

GO:0004607

GO:0004771

GO:0005515

GO:0005576

GO:0005615

GO:0006629

GO:0006644

GO:0006656

GO:0008202

GO:0008203

GO:0008374

GO:0016740

GO:0016746

GO:0016787

GO:0030301

GO:0034186

GO:0034364

GO:0034372

GO:0034375

GO:0042158

GO:0042632

GO:0043226

GO:0043691

GO:0046470

GO:0047179

GO:0065003

GO:0070062

GO:0090107

HMNXSV003004394

ILMN_1815102

M12625_at

PH_hs_0024416

g4557891_3p_a_at

Participates

as an output of

as a component of

as an input of

Inferred To

BcDNA.GH02384 [extracellular region] (Drosophila melanogaster)

LCAT [extracellular region] (Bos taurus)

LCAT [extracellular region] (Danio rerio)

LCAT [extracellular region] (Dictyostelium discoideum)

LCAT [extracellular region] (Gallus gallus)

LCAT [extracellular region] (Plasmodium falciparum)

LCAT [extracellular region] (Saccharomyces cerevisiae)

LCAT [extracellular region] (Sus scrofa)

Homologues of LCAT [extracellular region] (Drosophila melanogaster)

Homologues of LCAT [extracellular region] (Saccharomyces cerevisiae)

TGL2 [extracellular region] (Saccharomyces cerevisiae)

plag-15 [extracellular region] (Caenorhabditis elegans)

lcat [extracellular region] (Xenopus tropicalis)

Lcat [extracellular region] (Mus musculus)

Lcat [extracellular region] (Rattus norvegicus)

Dmel\CG18858 [extracellular region] (Drosophila melanogaster)

Cross References

RefSeq

NP_000220.1

OpenTargets

ENSG00000213398

GeneCards

P04180

HPA

ENSG00000213398-LCAT

Ensembl

ENSP00000264005, ENSG00000213398, ENST00000264005

PRO

P04180

Pharos - Targets

P04180

Orphanet

16341

HMDB Protein

HMDBP00069

PDB

4XWG, 4X96, 4XX1, 5BV7, 5TXF, 6MVD

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02647 APOA1	11	APOA1(25-266) [secretory granule lumen] (R-HSA-350761) APOA1(25-267) [cytosol] (R-HSA-2395781) APOA1(25-267) [early endosome] (R-HSA-2429641) APOA1(25-267) [endoplasmic reticulum lumen] (R-HSA-174640) APOA1(19-266) [extracellular region] (R-HSA-264771) APOA1(25-266) [plasma membrane] (R-HSA-216742) APOA1(25-266) [endocytic vesicle lumen] (R-HSA-2239460) Variant apolipoprotein AI [extracellular region] (R-HSA-976865) p-APOA1 [endoplasmic reticulum lumen] (R-HSA-8957081) APOA1 [endoplasmic reticulum lumen] (R-HSA-8956724) APOA1(25-266) [extracellular region] (R-HSA-174720)	0.623	2
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3

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