Reactome | SLC10A1 [plasma membrane]

SLC10A1 [plasma membrane]

Stable Identifier

R-HSA-194116

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

NTCP, Sodium/bile acid cotransporter, Na+ / taurocholate cotransporter

Locations in the PathwayBrowser for interactor UniProt:Q53HI1 UNC50

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External Reference Information

External Reference

UniProt:Q14973 SLC10A1

Gene Names

SLC10A1, NTCP, GIG29

Chain

chain:1-349

Reference Genes

BioGPS Gene:6554 SLC10A1

COSMIC (genes):SLC10A1 SLC10A1

CTD Gene:6554 SLC10A1

dbSNP Gene:6554 SLC10A1

ENSEMBL:ENSG00000100652 SLC10A1

ENSEMBL_homo_sapiens_GENE:ENSG00000100652.5 SLC10A1

HGNC:10905 SLC10A1

KEGG Gene (Homo sapiens):6554 SLC10A1

Monarch:6554 SLC10A1

NCBI Gene:6554 SLC10A1

OMIM:182396 SLC10A1

UCSC:Q14973 SLC10A1

Reference Transcript

RefSeq:NM_003049.3 SLC10A1

Other Identifiers

11734115_at

16794268

207185_PM_at

207185_at

34035_at

3570267

3570268

3570269

3570270

3570271

3570272

3570273

3570274

3570281

3570282

3570283

6554

7979878

A_23_P25698

GE57674

GO:0001618

GO:0005215

GO:0005515

GO:0005886

GO:0006811

GO:0006814

GO:0006869

GO:0008508

GO:0014070

GO:0015125

GO:0015293

GO:0015721

GO:0016020

GO:0016323

GO:0023052

GO:0031667

GO:0038183

GO:0043627

GO:0045471

GO:0046718

GO:0055085

GO:0071466

GO:0120188

HMNXSV003015747

ILMN_1776112

L21893_at

PH_hs_0000124

TC14001263.hg

g4506970_3p_at

Inferred To

SLC10A1 [plasma membrane] (Bos taurus)

SLC10A1 [plasma membrane] (Caenorhabditis elegans)

SLC10A1 [plasma membrane] (Canis familiaris)

SLC10A1 [plasma membrane] (Sus scrofa)

Slc10a1 [plasma membrane] (Mus musculus)

Slc10a1 [plasma membrane] (Rattus norvegicus)

Homologues of SLC10A1 [plasma membrane] (Drosophila melanogaster)

Dmel\CG11655 [plasma membrane] (Drosophila melanogaster)

Dmel\CG9903 [plasma membrane] (Drosophila melanogaster)

slc10a1 [plasma membrane] (Danio rerio)

slc10a1 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_003040.1

ZINC - World Drugs

NTCP_HUMAN

Guide to Pharmacology - Targets

959

OpenTargets

ENSG00000100652

ZINC - FDA approved

NTCP_HUMAN

ZINC - Substances

NTCP_HUMAN

ZINC target

Q14973

ZINC - Biogenic

NTCP_HUMAN

PRO

Q14973

PDB

7ZYI, 7WSI, 7PQG, 7VAG, 7PQQ, 8HRY, 7VAD, 8HRX, 7FCI, 8RQF

ZINC - Metabolites

NTCP_HUMAN

HPA

ENSG00000100652-SLC10A1

GeneCards

Q14973

Ensembl

ENSG00000100652, ENSP00000216540, ENST00000216540

Pharos - Targets

Q14973

ZINC - Predictions - Purchasable

NTCP_HUMAN

Orphanet

25425

HMDB Protein

HMDBP02550

Interactors (91)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P37268 FDFT1	1	FDFT1 [endoplasmic reticulum membrane] (R-HSA-191369)	0.556	3
UniProt:Q6ZPD8 DGAT2L6	1	DGAT2L6 [endoplasmic reticulum membrane] (R-HSA-8848588)	0.556	3
UniProt:Q99519 NEU1	8	NEU1 W23* [lysosomal lumen] (R-HSA-5674155) NEU1 W29* [lysosomal lumen] (R-HSA-5674174) NEU1 E377* [lysosomal lumen] (R-HSA-5674181) NEU1 R225P [lysosomal lumen] (R-HSA-5674167) NEU1 L303P [lysosomal lumen] (R-HSA-5674182) NEU1 [extracellular region] (R-HSA-6806158) NEU1 [specific granule lumen] (R-HSA-6806148) NEU1 [lysosomal lumen] (R-HSA-1605788)	0.556	3
UniProt:Q5RI15 COX20	1	COX20 [mitochondrial inner membrane] (R-HSA-5336169)	0.556	3
UniProt:Q99437 ATP6V0B	3	ATP6V0B [endosome membrane] (R-HSA-912584) ATP6V0B [phagocytic vesicle membrane] (R-HSA-1222695) ATP6V0B [lysosomal membrane] (R-HSA-9640187)	0.556	3
UniProt:P06681 C2	3	C2b [extracellular region] (R-HSA-166781) C2 [extracellular region] (R-HSA-166778) C2a [extracellular region] (R-HSA-166780)	0.556	3
UniProt:Q13021 MALL			0.556	3
UniProt:Q9H2L4 TMM60			0.556	3
UniProt:Q14802-3 FXYD3			0.556	3
UniProt:P11836 CD20			0.556	3
UniProt:Q99640-2 PKMYT1			0.556	3
UniProt:Q9Y666-2 SLC12A7			0.556	3
UniProt:Q7Z4F1 LRP10	1	LRP10 [plasma membrane] (R-HSA-2424275)	0.556	3
UniProt:Q9BSR8 YIPF4			0.556	3
UniProt:Q96B49 TOMM6	1	TOMM6 [mitochondrial outer membrane] (R-HSA-1252171)	0.556	3
UniProt:Q8WW34-2 TMEM239			0.556	3
UniProt:Q15836 VAMP3	6	VAMP3 [recycling endosome membrane] (R-HSA-2029063) VAMP3 [phagocytic vesicle membrane] (R-HSA-2029013) VAMP3 [plasma membrane] (R-HSA-8867599) VAMP3 [trans-Golgi network membrane] (R-HSA-6814624) VAMP3 [transport vesicle] (R-HSA-6814625) VAMP3 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869130)	0.556	3
UniProt:O14653 GOSR2	4	GOSR2 [endoplasmic reticulum membrane] (R-HSA-5689451) GOSR2 [ER to Golgi transport vesicle membrane] (R-HSA-5689800) GOSR2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-535472) GOSR2 [Golgi membrane] (R-HSA-6807755)	0.556	3
UniProt:Q8TDT2 GP152			0.556	3
UniProt:Q5TGU0 TSPO2			0.556	3
UniProt:Q9BUN8 DERL1	1	DERL1 [endoplasmic reticulum membrane] (R-HSA-6781898)	0.556	3
UniProt:Q8N138 ORMDL3	4	ORMDL3 [specific granule membrane] (R-HSA-6799643) ORMDL3 [plasma membrane] (R-HSA-6806293) ORMDL3 [secretory granule membrane] (R-HSA-6800882) ORMDL3 [endoplasmic reticulum membrane] (R-HSA-8865589)	0.556	3
UniProt:A5PKU2 A5PKU2			0.556	3
IntAct:EBI-22589183 CCSB ORF ID			0.556	3
UniProt:Q9BTD3 TM121			0.556	3
UniProt:Q8WV19 SFT2A			0.556	3
UniProt:Q9H0Q3 FXYD6	1	FXYD6 [plasma membrane] (R-HSA-2752104)	0.556	3
UniProt:Q96EC8 YIPF6	2	YIPF6 [Golgi membrane] (R-HSA-434346) YIPF6 [cytoplasmic vesicle membrane] (R-HSA-434199)	0.556	3
UniProt:Q6IBB0 Q6IBB0			0.556	3
UniProt:Q9NTJ5 SACM1L	2	SACM1L [endoplasmic reticulum membrane] (R-HSA-1604637) SACM1L [Golgi membrane] (R-HSA-1806242)	0.556	3
UniProt:Q6ICL7 S35E4			0.556	3
UniProt:Q9NWH2 TM242			0.556	3
UniProt:Q96D05-2 FAM241B			0.556	3
UniProt:Q969X1 TMBIM1	2	TMBIM1 [specific granule membrane] (R-HSA-6799704) TMBIM1 [plasma membrane] (R-HSA-6800472)	0.556	3
UniProt:Q96AG3 S2546			0.556	3
UniProt:O60906 SMPD2	1	SMPD2 [plasma membrane] (R-HSA-194337)	0.556	3
UniProt:Q7RTS5 OTOP3			0.556	3
UniProt:Q9H2H9 SLC38A1	1	SLC38A1 [plasma membrane] (R-HSA-212663)	0.556	3
UniProt:Q96F15 GIMA5			0.556	3
UniProt:P00387 CYB5R3	3	MyrG-CYB5R3(2-301) [mitochondrial outer membrane] (R-HSA-198771) CYB5R3(27-301) [extracellular region] (R-HSA-6806205) CYB5R3(27-301) [azurophil granule lumen] (R-HSA-6799217)	0.556	3
UniProt:Q9NRZ7 AGPAT3	2	AGPAT3 [Golgi membrane] (R-HSA-8849239) AGPAT3 [endoplasmic reticulum membrane] (R-HSA-61807)	0.556	3
UniProt:P21145 MAL			0.556	3
UniProt:P01350 GAST	1	GAST(76-92) [extracellular region] (R-HSA-870266)	0.556	3
UniProt:Q96MX0 CKLF3			0.556	3
UniProt:P48449 LSS	1	LSS [endoplasmic reticulum membrane] (R-HSA-191371)	0.556	3
UniProt:Q9H9B4 SFXN1			0.556	3
UniProt:Q8N6S5 AR6P6			0.556	3
UniProt:Q8WY07 SLC7A3	1	SLC7A3 [plasma membrane] (R-HSA-375779)	0.556	3
UniProt:Q8N6F1-2 CLDN19			0.556	3
UniProt:Q9H0R3 TM222			0.556	3
UniProt:A0PK00 T120B			0.556	3
UniProt:Q8WY98 TM234			0.556	3
UniProt:Q96FB2 Q96FB2			0.556	3
UniProt:Q53FV1 ORMDL2	1	ORMDL2 [endoplasmic reticulum membrane] (R-HSA-8865591)	0.556	3
UniProt:Q03518 TAP1	3	TAP1 [phagocytic vesicle membrane] (R-HSA-1236845) TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863953) TAP1 [endoplasmic reticulum membrane] (R-HSA-947474)	0.556	3
UniProt:O95562 SFT2B			0.556	3
UniProt:O15400 STX7			0.556	3
UniProt:A6NDP7 MADL2			0.556	3
UniProt:Q969E2 SCAM4			0.556	3
UniProt:Q53HI1 UNC50			0.556	3
UniProt:Q9BXR6 CFHR5	1	CFHR5 [extracellular region] (R-HSA-8851419)	0.556	3
UniProt:Q8TDV0 GP151			0.556	3
UniProt:Q8IVJ1 SLC41A1	1	SLC41A1 [plasma membrane] (R-HSA-442659)	0.556	3
UniProt:I3L0A0 I3L0A0			0.556	3
UniProt:P07306 ASGR1	1	PALM-C36-ASGR1 [plasma membrane] (R-HSA-8855714)	0.556	3
UniProt:Q9Y5Y5 PEX16	2	PEX16 [peroxisomal membrane] (R-HSA-9603805) PEX16 [cytosol] (R-HSA-9603790)	0.556	3
UniProt:O95070 YIF1A	1	YIF1A [endoplasmic reticulum membrane] (R-HSA-535599)	0.556	3
UniProt:Q01628 IFITM3	1	IFITM3 [plasma membrane] (R-HSA-1015688)	0.556	3
UniProt:O95393 BMP10	2	BMP10(22-424) [extracellular region] (R-HSA-2396409) BMP10 [extracellular region] (R-HSA-8858374)	0.556	3
UniProt:Q9Y6D0 SELK			0.556	3
UniProt:O95870 ABHGA			0.556	3
UniProt:Q96GQ5 RUSF1			0.556	3
IntAct:EBI-23343277 CCSB ORF ID			0.556	3
UniProt:Q9ULC5 ACSL5	1	ACSL5 [endoplasmic reticulum membrane] (R-HSA-165011)	0.556	3
UniProt:Q07325 CXCL9	1	CXCL9 [extracellular region] (R-HSA-373856)	0.556	3
UniProt:P02786 TFRC	5	TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (R-HSA-8869124) TFRC(1-760) [Golgi membrane] (R-HSA-434330) TFRC(1-760) [cytoplasmic vesicle membrane] (R-HSA-434196) TFRC(1-760) [plasma membrane] (R-HSA-917983) TFRC(1-760) [endosome membrane] (R-HSA-8961829)	0.556	3
UniProt:Q9P0S3 ORMDL1	1	ORMDL1 [endoplasmic reticulum membrane] (R-HSA-8865584)	0.556	3
UniProt:Q96IV6 FXDC2			0.556	3
UniProt:Q7L5A8 FA2H	1	FA2H [endoplasmic reticulum membrane] (R-HSA-5693771)	0.556	3
UniProt:Q9NYZ1 TV23B			0.556	3
IntAct:EBI-23683896 CCSB ORF ID			0.556	3
UniProt:Q6ZSS7 MFSD6			0.556	3
UniProt:P07357 C8A	1	C8A [extracellular region] (R-HSA-173716)	0.556	3
UniProt:Q71RG4 TMUB2			0.556	3
UniProt:Q9NVC3 S38A7			0.556	3
UniProt:Q8N2U9 S66A2			0.556	3
UniProt:Q9NZC3 GDE1	1	GDE1 [plasma membrane] (R-HSA-1498746)	0.556	3
UniProt:Q9NZG7 NINJ2			0.556	3
UniProt:Q7RTY0 MOT13			0.556	3
UniProt:Q9BVK8 TM147			0.556	3
UniProt:P0DTD3 ORF9C			0.488	2

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