Reactome | HSD11B2,HSD11B1 dimer oxidise CORT to COR

HSD11B2,HSD11B1 dimer oxidise CORT to COR

Stable Identifier

R-HSA-194023

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

cortisol + NADP(+) => cortisone + H(+) + NADPH

ReviewStatus

5/5

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HSD11B2,HSD11B1 dimer oxidise CORT to COR

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Cortisol and NADP+ react to form cortisone, NADPH, and H+. This reaction is catalyzed by 11beta-hydroxysteroid dehydrogenases 11B1 and B2 (HSD11B1, B2), associated with the endoplasmic reticulum membrane. The conversion of cortisol (CORT), an active hormone, into inactive cortisone (COR) occurs in many tissues in the body, notably in the liver, and appears to play a role in regulating cortisol activity (Tannin et al. 1991, Stewart et al. 1987).

Literature References

PubMed ID	Title	Journal	Year
2889032	Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age Wallace, AM, Stewart, PM, Edwards, CR, Valentino, R, Burt, D, Shackleton, CH	Lancet	1987
1885595	The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization. New, MI, Tannin, GM, White, PC, Monder, C, Agarwal, AK	J Biol Chem	1991