CYP11B1 oxidises 11DCORT

Stable Identifier
Reaction [transition]
Homo sapiens
11-deoxycortisol is oxidised to cortisol by CYP11B1, 11-deoxycortisol + NADPH + H+ + O2 => cortisol + NADP+ + H2O
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Cytochrome P450 11B1, mitochondrial (CYP11B1) usually hydroxylates 11-deoxycortisol (11DCORT) to form cortisol (CORT). CYP11B1 is associated with the inner mitochondrial membrane. Corticotropin (Adrenocorticotropic hormone, ACTH) acts through the ACTH receptor, melanocortin receptor type 2 (MC2R) to stimulate steroidogenesis, increasing the production of androgens (McKenna et al, 1997).

Literature References
PubMed ID Title Journal Year
1741400 Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans

Toda, K, Nakao, K, Ichikawa, Y, Ohnishi, T, Ulick, S, Kawamoto, T, Shizuta, Y, Miura, S, Miyahara, K, Yokoyama, Y, Imura, H, Mitsuuchi, Y

Proc Natl Acad Sci U S A 1992
9536209 A critical review of the origin and control of adrenal androgens

Fearon, U, Clarke, D, McKenna, TJ, Cunningham, SK

Baillieres Clin Obstet Gynaecol 1997
2592361 Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta)

Mornet, E, White, PC, Vitek, A, Dupont, J

J Biol Chem 1989
Catalyst Activity

steroid 11-beta-monooxygenase activity of Cytochrome P450 (CYP11B1 based) [mitochondrial inner membrane]

This event is regulated
Positively by
Orthologous Events
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