Reactome | CYP11B1 oxidises 11DCORT

CYP11B1 oxidises 11DCORT

Stable Identifier

R-HSA-193997

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix, mitochondrial inner membrane

Synonyms

11-deoxycortisol + 2 H(+) + O2 + 2 reduced (adrenodoxin) => cortisol + H2O + 2 oxidized (adrenodoxin), 11-deoxycortisol is oxidised to cortisol by CYP11B1, 11-deoxycortisol + NADPH + H+ + O2 => cortisol + NADP+ + H2O

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Biological oxidations (Homo sapiens)
  - Phase I - Functionalization of compounds (Homo sapiens)
    - Cytochrome P450 - arranged by substrate type (Homo sapiens)
      - Endogenous sterols (Homo sapiens)
        
        CYP11B1 oxidises 11DCORT (Homo sapiens)
- Metabolism of lipids (Homo sapiens)
  - Metabolism of steroids (Homo sapiens)
    - Metabolism of steroid hormones (Homo sapiens)
      - Glucocorticoid biosynthesis (Homo sapiens)
        
        CYP11B1 oxidises 11DCORT (Homo sapiens)

General

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Cytochrome P450 11B1, mitochondrial (CYP11B1) usually hydroxylates 11-deoxycortisol (11DCORT) to form cortisol (CORT). CYP11B1 is associated with the inner mitochondrial membrane. Corticotropin (Adrenocorticotropic hormone, ACTH) acts through the ACTH receptor, melanocortin receptor type 2 (MC2R) to stimulate steroidogenesis, increasing the production of androgens (McKenna et al, 1997).

Literature References

PubMed ID	Title	Journal	Year
1741400	Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans Kawamoto, T, Mitsuuchi, Y, Toda, K, Yokoyama, Y, Miyahara, K, Miura, S, Ohnishi, T, Ichikawa, Y, Nakao, K, Imura, H, Ulick, S, Shizuta, Y	Proc Natl Acad Sci U S A	1992
9536209	A critical review of the origin and control of adrenal androgens McKenna, TJ, Fearon, U, Clarke, D, Cunningham, SK	Baillieres Clin Obstet Gynaecol	1997
2592361	Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta) Mornet, E, Dupont, J, Vitek, A, White, PC	J Biol Chem	1989