Reactome | HSD11B1 [endoplasmic reticulum membrane]

HSD11B1 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-193975

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Corticosteroid 11-beta-dehydrogenase, isozyme 1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P28845 HSD11B1

Gene Names

HSD11B1, HSD11, HSD11L, SDR26C1

Chain

chain:1-292

Reference Genes

BioGPS Gene:3290 HSD11B1

COSMIC (genes):HSD11B1 HSD11B1

CTD Gene:3290 HSD11B1

dbSNP Gene:3290 HSD11B1

ENSEMBL:ENSG00000117594 HSD11B1

HGNC:5208 HSD11B1

Monarch:3290 HSD11B1

NCBI Gene:3290 HSD11B1

OMIM:600713 HSD11B1

UCSC:P28845 HSD11B1

Reference Transcript

Other Identifiers

11729221_a_at

11741778_a_at

11741779_s_at

16676988

205404_PM_at

205404_at

2378084

2378085

2378086

2378087

2378088

2378090

2378091

2378096

2378097

2378098

2378099

2378100

2378101

3290

35702_at

7909446

A_14_P112241

A_14_P121171

A_23_P63209

GE565721

GE61481

GO:0003824

GO:0005496

GO:0005783

GO:0005789

GO:0006629

GO:0006706

GO:0008202

GO:0008289

GO:0016020

GO:0016491

GO:0030324

GO:0042803

GO:0043226

GO:0043231

GO:0047022

GO:0048856

GO:0050661

GO:0070524

GO:0102196

HMNXSV003043509

ILMN_1811370

ILMN_2389501

ILMN_2389506

M76665_at

PH_hs_0014193

TC01001750.hg

g5031764_3p_at

Participates

as a component of

HSD11B1 dimer [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

HSD11B1 [endoplasmic reticulum membrane] (Canis familiaris)

HSD11B1 [endoplasmic reticulum membrane] (Danio rerio)

HSD11B1 [endoplasmic reticulum membrane] (Mus musculus)

HSD11B1 [endoplasmic reticulum membrane] (Rattus norvegicus)

HSD11B1 [endoplasmic reticulum membrane] (Sus scrofa)

HSD11B1B [endoplasmic reticulum membrane] (Gallus gallus)

hsd11b1 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Cross References

ZINC - World Drugs

DHI1_HUMAN

Guide to Pharmacology - Targets

2763

OpenTargets

ENSG00000117594

ENSEMBL

ENSP00000355995, ENSP00000355994, ENST00000367028, ENST00000367027

ZINC - FDA approved

DHI1_HUMAN

ZINC - Substances

DHI1_HUMAN

ZINC - Biogenic

DHI1_HUMAN

ZINC target

P28845

PRO

P28845

PDB

4C7J, 3OQ1, 3PDJ, 3H6K, 4C7K, 2BEL, 3D4N, 3TFQ, 4K1L, 4YYZ, 5QII, 3QQP, 3CZR, 2RBE, 5PGU, 4HFR, 1XU9, 1XU7, 4IJU, 3BZU, 5PGV, 4IJV, 3FRJ, 5PGW, 4HX5, 4IJW, 3BYZ, 3D3E, 4BB5, 3D5Q, 5PGY, 4P38, 3HFG, 3EY4, 5PGX, 4BB6, 2ILT, 2IRW, 3FCO, 3CH6

ZINC - Investigational

DHI1_HUMAN

ZINC - Metabolites

DHI1_HUMAN

HPA

ENSG00000117594-HSD11B1

Pharos - Targets

P28845

Orphanet

HSD11B1

ZINC - Predictions - Purchasable

DHI1_HUMAN

HMDB Protein

HMDBP00718

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16880 UGT8	1	UGT8 [endoplasmic reticulum membrane] (R-HSA-9844570)	0.527	2