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SQSTM1 [cytosol]
Stable Identifier
R-HSA-193937
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p62, Sequestosome-1, SQSTM_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q15334 L2GL1
Expand all
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
Selective autophagy (Homo sapiens)
Mitophagy (Homo sapiens)
Pink/Parkin Mediated Mitophagy (Homo sapiens)
p62 binds ubiquitinated mitochondrial substrates (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signalling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRIF signals cell death from the nucleus (Homo sapiens)
Polyubiquitinated NRIF binds to p62 (Sequestosome) (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
p75NTR signals via NF-kB (Homo sapiens)
p75NTR recruits signalling complexes (Homo sapiens)
p62 is recruited and forms a complex with TRAF6 (Homo sapiens)
SQSTM1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13501 SQSTM1
Gene Names
SQSTM1, ORCA, OSIL
Chain
initiator methionine:1, chain:2-440
Reference Genes
BioGPS Gene:8878 SQSTM1
COSMIC (genes):SQSTM1 SQSTM1
CTD Gene:8878 SQSTM1
dbSNP Gene:8878 SQSTM1
ENSEMBL:ENSG00000161011 SQSTM1
HGNC:11280 SQSTM1
KEGG Gene (Homo sapiens):8878 SQSTM1
Monarch:8878 SQSTM1
NCBI Gene:8878 SQSTM1
OMIM:601530 SQSTM1
UCSC:Q13501 SQSTM1
Reference Transcript
RefSeq:XM_017010010.1 SQSTM1
RefSeq:NM_001142298.1 SQSTM1
RefSeq:NM_001142299.1 SQSTM1
RefSeq:NM_003900.4 SQSTM1
Other Identifiers
0000730647
11717290_s_at
11727031_a_at
11745754_x_at
11752843_x_at
11756761_x_at
16993458
1Q02
201471_s_at
213112_s_at
2844499
2844500
2844505
2844506
2844507
2844508
2844509
2844512
2844513
2844514
2844515
2844516
2844518
2844523
2844524
2844528
2844529
2844535
2844536
2844537
2844538
2844539
2844540
2844541
2844542
2JY7
2JY8
2K0B
2KNV
40898_at
4587
4MJS
4UF8
4UF9
5YP7
5YP8
5YPA
5YPB
5YPC
5YPE
5YPF
5YPG
5YPH
64165
68843
6MJ7
8110569
8878
A_14_P109999
A_23_P81399
AAA93299
AAC52070
AAC64516
AAH00951
AAH01874
AAH03139
AAH17222
AAH19111
AC008393
AF060494
AK098077
AK312451
BAG35358
BAG53577
BC000951
BC001874
BC003139
BC017222
BC019111
C9J6J8
C9JRJ8
CAB004587
CCDS34317
CCDS47355
D6RBF1
E3W990
E7EMC7
E9PFW8
ENSG00000161011
ENSP00000353944
ENSP00000374455
ENST00000360718
ENST00000360718.5
ENST00000389805
ENST00000389805.8
EntrezGene:8878
EntrezGene:SQSTM1
g4505570_3p_s_at
GE79794
GO:0000122
GO:0000407
GO:0000422
GO:0000423
GO:0000932
GO:0001934
GO:0002376
GO:0002931
GO:0003674
GO:0004674
GO:0005080
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005764
GO:0005768
GO:0005770
GO:0005773
GO:0005776
GO:0005783
GO:0005829
GO:0005929
GO:0006464
GO:0006468
GO:0006511
GO:0006810
GO:0006914
GO:0006915
GO:0006950
GO:0007005
GO:0007032
GO:0007165
GO:0007267
GO:0008104
GO:0008150
GO:0008219
GO:0008270
GO:0009056
GO:0009058
GO:0010821
GO:0016192
GO:0016197
GO:0016234
GO:0016235
GO:0016236
GO:0016301
GO:0016605
GO:0019899
GO:0019901
GO:0022607
GO:0030017
GO:0030154
GO:0030971
GO:0031410
GO:0031625
GO:0032182
GO:0032991
GO:0034641
GO:0035255
GO:0035556
GO:0035973
GO:0042169
GO:0042802
GO:0042803
GO:0043065
GO:0043066
GO:0043122
GO:0043130
GO:0043167
GO:0043226
GO:0043231
GO:0044753
GO:0044754
GO:0045944
GO:0046578
GO:0046872
GO:0051291
GO:0061635
GO:0061912
GO:0065003
GO:0070062
GO:0070498
GO:0070530
GO:0097225
GO:0097413
GO:0098780
GO:1900273
GO:1903078
GO:1905719
HGNC:11280
HPA064165
HPA068843
Hs.279891.1.A1_3p_at
ILMN_1662618
ILMN_1703856
IPR000270
IPR000433
IPR009060
IPR015940
IPR033741
IPR034866
MIM:167250
MIM:601530
MIM:616437
MIM:617145
MIM:617158
NM_001142298
NM_001142299
NM_003900
NP_001135770
NP_001135771
NP_003891
PF00564
PF00569
PF16577
PH_hs_0010763
SM00165
SM00291
SM00666
SQSTM1
SQSTM1-201
SQSTM1-202
U41806
U46751
U46751_at
UPI0000071099
UPI000007291E
XP_016865499
Participant Of
input
p62 binds ubiquitinated mitochondrial substrates
p62 is recruited and forms a complex with TRAF6
Polyubiquitinated NRIF binds to p62 (Sequestosome)
hasComponent
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane]
MAP3K3:SQSTM1 [cytosol]
NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane]
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane]
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane]
Ubiquitinated NRIF:Sequestosome [cytosol]
Other forms of this molecule
SQSTM1 [nucleoplasm]
Inferred To
SQSTM1 [cytosol] (Bos taurus)
SQSTM1 [cytosol] (Caenorhabditis elegans)
SQSTM1 [cytosol] (Canis familiaris)
SQSTM1 [cytosol] (Danio rerio)
SQSTM1 [cytosol] (Drosophila melanogaster)
SQSTM1 [cytosol] (Gallus gallus)
SQSTM1 [cytosol] (Mus musculus)
SQSTM1 [cytosol] (Rattus norvegicus)
SQSTM1 [cytosol] (Sus scrofa)
SQSTM1 [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
NP_001135770.1
,
NP_003891.1
,
XP_016865499.1
,
NP_001135771.1
OpenTargets
ENSG00000161011
GeneCards
Q13501
PRO
Q13501
Orphanet
20429
PDB
4UF9
,
4MJS
,
5YPG
,
2K0B
,
5YPB
,
5YP7
,
2JY8
,
2JY7
,
1Q02
,
6MJ7
,
5YPA
,
2KNV
,
4UF8
,
5YPF
,
5YPE
,
5YP8
,
5YPH
,
5YPC
Interactors (35)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9GZQ8 MAP1LC3B
3
MAP1LC3B [autophagosome membrane]
(R-HSA-5683641)
MAP1LC3B [cytosol]
(R-HSA-5205651)
MAP1LC3B(2-121) [cytosol]
(R-HSA-5682674)
0.968
23
UniProt:P60520 GABARAPL2
3
GABARAPL2 [autophagosome membrane]
(R-HSA-5683633)
GABARAPL2(1-117) [cytosol]
(R-HSA-5682641)
GABARAPL2 [cytosol]
(R-HSA-5671758)
0.958
19
UniProt:Q14145 KEAP1
2
KEAP1 [cytosol]
(R-HSA-976038)
Ub-KEAP1 [cytosol]
(R-HSA-6782766)
0.952
16
UniProt:O95166 GABARAP
3
GABARAP [autophagosome membrane]
(R-HSA-5683634)
GABARAP [cytosol]
(R-HSA-975521)
GABARAP(1-117) [cytosol]
(R-HSA-5682696)
0.888
13
UniProt:Q9H0R8 GABARAPL1
3
GABARAPL1 [autophagosome membrane]
(R-HSA-5683637)
GABARAPL1 [cytosol]
(R-HSA-5671757)
GABARAPL1(1-117) [cytosol]
(R-HSA-5682659)
0.887
14
UniProt:Q13501 SQSTM1
2
SQSTM1 [nucleoplasm]
(R-HSA-210961)
SQSTM1 [cytosol]
(R-HSA-193937)
0.879
7
UniProt:Q9H492 MAP1LC3A
3
MAP1LC3A [autophagosome membrane]
(R-HSA-5683640)
MAP1LC3A(1-121) [cytosol]
(R-HSA-5682681)
MAP1LC3A [cytosol]
(R-HSA-5205676)
0.855
9
IntAct:EBI-4399559 UBIQ
0.829
6
UniProt:P41743 PRKCI
3
PRKCI [cytosol]
(R-HSA-58206)
PRKCI [nucleoplasm]
(R-HSA-9021345)
PRKCI [plasma membrane]
(R-HSA-420005)
0.809
7
UniProt:P0CG48 UBC
334
UBC(533-608) [endocytic vesicle membrane]
(R-HSA-939220)
UBC(381-456) [endocytic vesicle membrane]
(R-HSA-939218)
UBC(609-684) [endocytic vesicle membrane]
(R-HSA-939223)
UBC(457-532) [endocytic vesicle membrane]
(R-HSA-939195)
UBC(153-228) [endocytic vesicle membrane]
(R-HSA-939194)
UBC(305-380) [endocytic vesicle membrane]
(R-HSA-939228)
UBC(229-304) [endocytic vesicle membrane]
(R-HSA-939177)
UBC(77-152) [endocytic vesicle membrane]
(R-HSA-939210)
UBC(1-76) [endocytic vesicle membrane]
(R-HSA-939245)
Ub-566-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783166)
Ub-338-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783121)
Ub-186-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783154)
Ub-262-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783028)
Ub-414-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783061)
Ub-110-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783158)
Ub-642-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783182)
Ub-33-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783073)
Ub-488-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783078)
Ub-291-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783193)
Ub-595-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783130)
Ub-443-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783153)
Ub-139-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783155)
Ub-63-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783094)
Ub-671-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783083)
Ub-519-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783053)
Ub-367-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783105)
Ub-215-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783137)
Ub-386-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783067)
Ub-6-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783122)
Ub-310-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783027)
Ub-234-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783157)
Ub-614-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783063)
Ub-462-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783118)
Ub-538-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783011)
Ub-158-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783140)
Ub-82-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783175)
Ub-315-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783089)
Ub-163-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783091)
Ub-543-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783060)
Ub-239-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783092)
Ub-619-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783125)
Ub-467-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783181)
Ub-11-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783104)
Ub-391-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783170)
Ub-87-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783110)
Ub-656-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783134)
Ub-124-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783120)
Ub-428-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783090)
Ub-48-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783029)
Ub-504-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783113)
Ub-200-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783150)
Ub-580-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783119)
Ub-276-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783183)
Ub-352-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783201)
Ub-29-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783064)
Ub-182-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783097)
Ub-486-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783194)
Ub-334-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783199)
Ub-638-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783188)
Ub-106-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783031)
Ub-258-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783016)
Ub-562-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783172)
Ub-410-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783077)
Ub-636-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783128)
Ub-104-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783032)
Ub-256-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783004)
Ub-484-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783156)
Ub-27-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783022)
Ub-332-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783138)
Ub-180-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783107)
Ub-408-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783108)
Ub-560-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783174)
N6-glycyl-L-lysine-UBC(457-532) [cytosol]
(R-HSA-8869048)
N6-glycyl-L-lysine-UBC(609-684) [cytosol]
(R-HSA-8869052)
N6-glycyl-L-lysine-UBC(229-304) [cytosol]
(R-HSA-8869032)
N6-glycyl-L-lysine-UBC(533-608) [cytosol]
(R-HSA-8869033)
N6-glycyl-L-lysine-UBC(153-228) [cytosol]
(R-HSA-8869035)
N6-glycyl-L-lysine-UBC(305-380) [cytosol]
(R-HSA-8869036)
N6-glycyl-L-lysine-UBC(77-152) [cytosol]
(R-HSA-8869026)
N6-glycyl-L-lysine-UBC(1-76) [cytosol]
(R-HSA-8869030)
N6-glycyl-L-lysine-UBC(381-456) [cytosol]
(R-HSA-8869031)
Ub-29-UBC(1-76) [cytosol]
(R-HSA-5689165)
Ub-258-UBC(229-304) [cytosol]
(R-HSA-5689167)
Ub-334-UBC(305-380) [cytosol]
(R-HSA-5689166)
Ub-410-UBC(381-456) [cytosol]
(R-HSA-5689185)
Ub-486-UBC(457-532) [cytosol]
(R-HSA-5689176)
Ub-562-UBC(533-608) [cytosol]
(R-HSA-5689151)
Ub-106-UBC(77-152) [cytosol]
(R-HSA-5689183)
Ub-182-UBC(153-228) [cytosol]
(R-HSA-5689169)
Ub-638-UBC(609-684) [cytosol]
(R-HSA-5689136)
Ub-310-UBC(305-380) [cytosol]
(R-HSA-5689097)
Ub-6-UBC(1-76) [cytosol]
(R-HSA-5689091)
Ub-462-UBC(457-532) [cytosol]
(R-HSA-5689092)
Ub-386-UBC(381-456) [cytosol]
(R-HSA-5689086)
Ub-538-UBC(533-608) [cytosol]
(R-HSA-5689104)
Ub-158-UBC(153-228) [cytosol]
(R-HSA-5689107)
Ub-614-UBC(609-684) [cytosol]
(R-HSA-5689076)
Ub-234-UBC(229-304) [cytosol]
(R-HSA-5689110)
Ub-82-UBC(77-152) [cytosol]
(R-HSA-5689078)
Ub-110-UBC(77-152) [cytosol]
(R-HSA-5689196)
Ub-33-UBC(1-76) [cytosol]
(R-HSA-5689134)
Ub-488-UBC(457-532) [cytosol]
(R-HSA-5689153)
Ub-338-UBC(305-380) [cytosol]
(R-HSA-5689152)
Ub-642-UBC(609-684) [cytosol]
(R-HSA-5689218)
Ub-414-UBC(381-456) [cytosol]
(R-HSA-5689157)
Ub-262-UBC(229-304) [cytosol]
(R-HSA-5689150)
Ub-566-UBC(533-608) [cytosol]
(R-HSA-5689205)
Ub-186-UBC(153-228) [cytosol]
(R-HSA-5689140)
adenylatedG608-UBC(533-608) [nucleoplasm]
(R-HSA-8852090)
adenylatedG380-UBC(305-380) [nucleoplasm]
(R-HSA-8852093)
adenylatedG532-UBC(457-532) [nucleoplasm]
(R-HSA-8852081)
adenylatedG304-UBC(229-304) [nucleoplasm]
(R-HSA-8852050)
adenylatedG152-UBC(77-152) [nucleoplasm]
(R-HSA-8852054)
adenylatedG684-UBC(609-684) [nucleoplasm]
(R-HSA-8852105)
adenylatedG228-UBC(153-228) [nucleoplasm]
(R-HSA-8852075)
adenylatedG76-UBC(1-76) [nucleoplasm]
(R-HSA-8852044)
adenylatedG456-UBC(381-456) [nucleoplasm]
(R-HSA-8852098)
UBC [cytosol]
(R-HSA-8853531)
adenylatedG380-UBC(305-380) [cytosol]
(R-HSA-8852062)
adenylatedG608-UBC(533-608) [cytosol]
(R-HSA-8852052)
adenylatedG76-UBC(1-76) [cytosol]
(R-HSA-8852053)
adenylatedG304-UBC(229-304) [cytosol]
(R-HSA-8852117)
adenylatedG684-UBC(609-684) [cytosol]
(R-HSA-8852118)
adenylatedG152-UBC(77-152) [cytosol]
(R-HSA-8852087)
adenylatedG532-UBC(457-532) [cytosol]
(R-HSA-8852045)
adenylatedG228-UBC(153-228) [cytosol]
(R-HSA-8852111)
adenylatedG456-UBC(381-456) [cytosol]
(R-HSA-8852069)
Ub-428-UBC(381-456) [endoplasmic reticulum membrane]
(R-HSA-8943062)
Ub-656-UBC(609-684) [endoplasmic reticulum membrane]
(R-HSA-8943120)
Ub-124-UBC(77-152) [endoplasmic reticulum membrane]
(R-HSA-8943129)
Ub-48-UBC(1-76) [endoplasmic reticulum membrane]
(R-HSA-8943079)
Ub-352-UBC(305-380) [endoplasmic reticulum membrane]
(R-HSA-8943108)
Ub-504-UBC(457-532) [endoplasmic reticulum membrane]
(R-HSA-8943075)
Ub-276-UBC(229-304) [endoplasmic reticulum membrane]
(R-HSA-8943106)
Ub-580-UBC(533-608) [endoplasmic reticulum membrane]
(R-HSA-8943137)
Ub-200-UBC(153-228) [endoplasmic reticulum membrane]
(R-HSA-8943087)
UBC(77-152) [endoplasmic reticulum membrane]
(R-HSA-8943095)
UBC(381-456) [endoplasmic reticulum membrane]
(R-HSA-8943126)
UBC(533-608) [endoplasmic reticulum membrane]
(R-HSA-8943061)
UBC(609-684) [endoplasmic reticulum membrane]
(R-HSA-8943135)
UBC(229-304) [endoplasmic reticulum membrane]
(R-HSA-8943103)
UBC(153-228) [endoplasmic reticulum membrane]
(R-HSA-8943068)
UBC(1-76) [endoplasmic reticulum membrane]
(R-HSA-8943077)
UBC(305-380) [endoplasmic reticulum membrane]
(R-HSA-8943084)
UBC(457-532) [endoplasmic reticulum membrane]
(R-HSA-8943112)
UBC(1-76) [plasma membrane]
(R-HSA-3149469)
UBC(457-532) [plasma membrane]
(R-HSA-3149468)
UBC(153-228) [plasma membrane]
(R-HSA-3149467)
UBC(609-684) [plasma membrane]
(R-HSA-3149466)
UBC(77-152) [plasma membrane]
(R-HSA-3149465)
UBC(229-304) [plasma membrane]
(R-HSA-3149464)
UBC(533-608) [plasma membrane]
(R-HSA-3149462)
UBC(381-456) [plasma membrane]
(R-HSA-3149459)
UBC(305-380) [plasma membrane]
(R-HSA-3149458)
UBC(1-76) [endosome membrane]
(R-HSA-939187)
UBC(533-608) [endosome membrane]
(R-HSA-939221)
UBC(77-152) [endosome membrane]
(R-HSA-939161)
UBC(305-380) [endosome membrane]
(R-HSA-939196)
UBC(457-532) [endosome membrane]
(R-HSA-939199)
UBC(381-456) [endosome membrane]
(R-HSA-939166)
UBC(153-228) [endosome membrane]
(R-HSA-939170)
UBC(609-684) [endosome membrane]
(R-HSA-939237)
UBC(229-304) [endosome membrane]
(R-HSA-939172)
Ub-256-UBC(229-304) [cytosol]
(R-HSA-5689135)
Ub-180-UBC(153-228) [cytosol]
(R-HSA-5689221)
Ub-104-UBC(77-152) [cytosol]
(R-HSA-5689189)
Ub-484-UBC(457-532) [cytosol]
(R-HSA-5689220)
Ub-560-UBC(533-608) [cytosol]
(R-HSA-5689145)
Ub-636-UBC(609-684) [cytosol]
(R-HSA-5689144)
Ub-332-UBC(305-380) [cytosol]
(R-HSA-5689211)
Ub-27-UBC(1-76) [cytosol]
(R-HSA-5689179)
Ub-408-UBC(381-456) [cytosol]
(R-HSA-5689182)
Ub-87-UBC(77-152) [cytosol]
(R-HSA-3095920)
Ub-163-UBC(153-228) [cytosol]
(R-HSA-3095924)
Ub-619-UBC(609-684) [cytosol]
(R-HSA-3095925)
Ub-467-UBC(457-532) [cytosol]
(R-HSA-3095935)
Ub-11-UBC(1-76) [cytosol]
(R-HSA-3095906)
Ub-543-UBC(533-608) [cytosol]
(R-HSA-3095912)
Ub-391-UBC(381-456) [cytosol]
(R-HSA-3095914)
Ub-315-UBC(305-380) [cytosol]
(R-HSA-3095916)
Ub-239-UBC(229-304) [cytosol]
(R-HSA-3095919)
Ub-519-UBC(457-532) [endosome membrane]
(R-HSA-939227)
Ub-367-UBC(305-380) [endosome membrane]
(R-HSA-939162)
Ub-291-UBC(229-304) [endosome membrane]
(R-HSA-939226)
Ub-443-UBC(381-456) [endosome membrane]
(R-HSA-939204)
Ub-215-UBC(153-228) [endosome membrane]
(R-HSA-939175)
Ub-63-UBC(1-76) [endosome membrane]
(R-HSA-939174)
Ub-595-UBC(533-608) [endosome membrane]
(R-HSA-939242)
Ub-139-UBC(77-152) [endosome membrane]
(R-HSA-939244)
Ub-671-UBC(609-684) [endosome membrane]
(R-HSA-939183)
Ub-291-UBC(229-304) [plasma membrane]
(R-HSA-939859)
Ub-595-UBC(533-608) [plasma membrane]
(R-HSA-939858)
Ub-367-UBC(305-380) [plasma membrane]
(R-HSA-939861)
Ub-63-UBC(1-76) [plasma membrane]
(R-HSA-939860)
Ub-139-UBC(77-152) [plasma membrane]
(R-HSA-939865)
Ub-215-UBC(153-228) [plasma membrane]
(R-HSA-939864)
Ub-519-UBC(457-532) [plasma membrane]
(R-HSA-939845)
Ub-671-UBC(609-684) [plasma membrane]
(R-HSA-939846)
Ub-443-UBC(381-456) [plasma membrane]
(R-HSA-939848)
Ub-408-UBC(381-456) [nucleoplasm]
(R-HSA-6782681)
Ub-484-UBC(457-532) [nucleoplasm]
(R-HSA-6782650)
Ub-104-UBC(77-152) [nucleoplasm]
(R-HSA-6782651)
Ub-256-UBC(229-304) [nucleoplasm]
(R-HSA-6782641)
Ub-180-UBC(153-228) [nucleoplasm]
(R-HSA-6782603)
Ub-560-UBC(533-608) [nucleoplasm]
(R-HSA-6782637)
Ub-27-UBC(1-76) [nucleoplasm]
(R-HSA-6782625)
Ub-636-UBC(609-684) [nucleoplasm]
(R-HSA-6782597)
Ub-332-UBC(305-380) [nucleoplasm]
(R-HSA-6782630)
Ub-638-UBC(609-684) [nucleoplasm]
(R-HSA-6782680)
Ub-258-UBC(229-304) [nucleoplasm]
(R-HSA-6782621)
Ub-562-UBC(533-608) [nucleoplasm]
(R-HSA-6782672)
Ub-410-UBC(381-456) [nucleoplasm]
(R-HSA-6782642)
Ub-182-UBC(153-228) [nucleoplasm]
(R-HSA-6782678)
Ub-106-UBC(77-152) [nucleoplasm]
(R-HSA-6782602)
Ub-334-UBC(305-380) [nucleoplasm]
(R-HSA-6782638)
Ub-29-UBC(1-76) [nucleoplasm]
(R-HSA-6782659)
Ub-486-UBC(457-532) [nucleoplasm]
(R-HSA-6782661)
Ub-671-UBC(609-684) [nucleoplasm]
(R-HSA-6782523)
Ub-215-UBC(153-228) [nucleoplasm]
(R-HSA-6782491)
Ub-63-UBC(1-76) [nucleoplasm]
(R-HSA-6782492)
Ub-443-UBC(381-456) [nucleoplasm]
(R-HSA-6782480)
Ub-367-UBC(305-380) [nucleoplasm]
(R-HSA-6782479)
Ub-139-UBC(77-152) [nucleoplasm]
(R-HSA-6782496)
Ub-519-UBC(457-532) [nucleoplasm]
(R-HSA-6782497)
Ub-595-UBC(533-608) [nucleoplasm]
(R-HSA-6782499)
Ub-291-UBC(229-304) [nucleoplasm]
(R-HSA-6782500)
Ub-48-UBC(1-76) [nucleoplasm]
(R-HSA-6782524)
Ub-428-UBC(381-456) [nucleoplasm]
(R-HSA-6782462)
Ub-504-UBC(457-532) [nucleoplasm]
(R-HSA-6782512)
Ub-276-UBC(229-304) [nucleoplasm]
(R-HSA-6782482)
Ub-200-UBC(153-228) [nucleoplasm]
(R-HSA-6782487)
Ub-656-UBC(609-684) [nucleoplasm]
(R-HSA-6782474)
Ub-580-UBC(533-608) [nucleoplasm]
(R-HSA-6782477)
Ub-124-UBC(77-152) [nucleoplasm]
(R-HSA-6782498)
Ub-352-UBC(305-380) [nucleoplasm]
(R-HSA-6782467)
Ub-467-UBC(457-532) [nucleoplasm]
(R-HSA-6782619)
Ub-163-UBC(153-228) [nucleoplasm]
(R-HSA-6782622)
Ub-11-UBC(1-76) [nucleoplasm]
(R-HSA-6782609)
Ub-87-UBC(77-152) [nucleoplasm]
(R-HSA-6782632)
Ub-239-UBC(229-304) [nucleoplasm]
(R-HSA-6782669)
Ub-543-UBC(533-608) [nucleoplasm]
(R-HSA-6782594)
Ub-391-UBC(381-456) [nucleoplasm]
(R-HSA-6782626)
Ub-315-UBC(305-380) [nucleoplasm]
(R-HSA-6782660)
Ub-619-UBC(609-684) [nucleoplasm]
(R-HSA-6782662)
Ub-186-UBC(153-228) [nucleoplasm]
(R-HSA-6782617)
Ub-338-UBC(305-380) [nucleoplasm]
(R-HSA-6782620)
Ub-33-UBC(1-76) [nucleoplasm]
(R-HSA-6782653)
Ub-110-UBC(77-152) [nucleoplasm]
(R-HSA-6782590)
Ub-262-UBC(229-304) [nucleoplasm]
(R-HSA-6782640)
Ub-642-UBC(609-684) [nucleoplasm]
(R-HSA-6782674)
Ub-566-UBC(533-608) [nucleoplasm]
(R-HSA-6782646)
Ub-414-UBC(381-456) [nucleoplasm]
(R-HSA-6782636)
Ub-488-UBC(457-532) [nucleoplasm]
(R-HSA-6782599)
Ub-82-UBC(77-152) [nucleoplasm]
(R-HSA-6782675)
Ub-6-UBC(1-76) [nucleoplasm]
(R-HSA-6782611)
Ub-234-UBC(229-304) [nucleoplasm]
(R-HSA-6782677)
Ub-158-UBC(153-228) [nucleoplasm]
(R-HSA-6782645)
Ub-310-UBC(305-380) [nucleoplasm]
(R-HSA-6782614)
Ub-538-UBC(533-608) [nucleoplasm]
(R-HSA-6782664)
Ub-462-UBC(457-532) [nucleoplasm]
(R-HSA-6782634)
Ub-386-UBC(381-456) [nucleoplasm]
(R-HSA-6782605)
Ub-614-UBC(609-684) [nucleoplasm]
(R-HSA-6782657)
UBC(229-304) [nucleoplasm]
(R-HSA-939857)
UBC(381-456) [nucleoplasm]
(R-HSA-939856)
UBC(305-380) [nucleoplasm]
(R-HSA-939863)
UBC(457-532) [nucleoplasm]
(R-HSA-939862)
UBC(533-608) [nucleoplasm]
(R-HSA-939866)
UBC(77-152) [nucleoplasm]
(R-HSA-939869)
UBC(609-684) [nucleoplasm]
(R-HSA-939868)
UBC(1-76) [nucleoplasm]
(R-HSA-939871)
UBC(153-228) [nucleoplasm]
(R-HSA-939853)
Ub-124-UBC(77-152) [nucleoplasm]
(R-HSA-5683048)
Ub-580-UBC(533-608) [nucleoplasm]
(R-HSA-5683050)
Ub-428-UBC(381-456) [nucleoplasm]
(R-HSA-5683041)
Ub-276-UBC(229-304) [nucleoplasm]
(R-HSA-5683042)
Ub-352-UBC(305-380) [nucleoplasm]
(R-HSA-5683045)
Ub-200-UBC(153-228) [nucleoplasm]
(R-HSA-5683046)
Ub-48-UBC(1-76) [nucleoplasm]
(R-HSA-5683033)
Ub-656-UBC(609-684) [nucleoplasm]
(R-HSA-5683035)
Ub-504-UBC(457-532) [nucleoplasm]
(R-HSA-5683039)
Ub-671-UBC(609-684) [nucleoplasm]
(R-HSA-5682857)
Ub-139-UBC(77-152) [nucleoplasm]
(R-HSA-5682856)
Ub-519-UBC(457-532) [nucleoplasm]
(R-HSA-5682848)
Ub-63-UBC(1-76) [nucleoplasm]
(R-HSA-5682852)
Ub-595-UBC(533-608) [nucleoplasm]
(R-HSA-5682841)
Ub-215-UBC(153-228) [nucleoplasm]
(R-HSA-5682840)
Ub-443-UBC(381-456) [nucleoplasm]
(R-HSA-5682843)
Ub-291-UBC(229-304) [nucleoplasm]
(R-HSA-5682842)
Ub-367-UBC(305-380) [nucleoplasm]
(R-HSA-5682837)
UBC(609-684) [late endosome lumen]
(R-HSA-9660012)
UBC(153-228) [late endosome lumen]
(R-HSA-9659979)
UBC(305-380) [late endosome lumen]
(R-HSA-9660033)
UBC(77-152) [late endosome lumen]
(R-HSA-9659992)
UBC(533-608) [late endosome lumen]
(R-HSA-9659993)
UBC(229-304) [late endosome lumen]
(R-HSA-9659994)
UBC(457-532) [late endosome lumen]
(R-HSA-9659995)
UBC(381-456) [late endosome lumen]
(R-HSA-9660023)
UBC(1-76) [late endosome lumen]
(R-HSA-9659985)
Ub-48-UBC(1-76) [cytosol]
(R-HSA-939219)
Ub-656-UBC(609-684) [cytosol]
(R-HSA-939255)
Ub-428-UBC(381-456) [cytosol]
(R-HSA-939190)
Ub-504-UBC(457-532) [cytosol]
(R-HSA-939257)
Ub-580-UBC(533-608) [cytosol]
(R-HSA-939256)
Ub-276-UBC(229-304) [cytosol]
(R-HSA-939207)
Ub-124-UBC(77-152) [cytosol]
(R-HSA-939209)
Ub-200-UBC(153-228) [cytosol]
(R-HSA-939179)
Ub-352-UBC(305-380) [cytosol]
(R-HSA-939181)
UBC(457-532) [cytosol]
(R-HSA-939184)
UBC(1-76) [cytosol]
(R-HSA-939188)
UBC(381-456) [cytosol]
(R-HSA-939191)
UBC(229-304) [cytosol]
(R-HSA-939192)
UBC(153-228) [cytosol]
(R-HSA-939258)
UBC(609-684) [cytosol]
(R-HSA-939165)
UBC(77-152) [cytosol]
(R-HSA-939164)
UBC(305-380) [cytosol]
(R-HSA-939232)
UBC(533-608) [cytosol]
(R-HSA-939239)
UBC(1-76) [lysosomal lumen]
(R-HSA-9659981)
UBC(305-380) [lysosomal lumen]
(R-HSA-9660008)
UBC(77-152) [lysosomal lumen]
(R-HSA-9659978)
UBC(609-684) [lysosomal lumen]
(R-HSA-9660020)
UBC(153-228) [lysosomal lumen]
(R-HSA-9659988)
UBC(457-532) [lysosomal lumen]
(R-HSA-9659989)
UBC(381-456) [lysosomal lumen]
(R-HSA-9659984)
UBC(229-304) [lysosomal lumen]
(R-HSA-9660018)
UBC(533-608) [lysosomal lumen]
(R-HSA-9659987)
Ub-215-UBC(153-228) [cytosol]
(R-HSA-939186)
Ub-139-UBC(77-152) [cytosol]
(R-HSA-939254)
Ub-595-UBC(533-608) [cytosol]
(R-HSA-939198)
Ub-291-UBC(229-304) [cytosol]
(R-HSA-939173)
Ub-367-UBC(305-380) [cytosol]
(R-HSA-939206)
Ub-671-UBC(609-684) [cytosol]
(R-HSA-939241)
Ub-63-UBC(1-76) [cytosol]
(R-HSA-939176)
Ub-519-UBC(457-532) [cytosol]
(R-HSA-939212)
Ub-443-UBC(381-456) [cytosol]
(R-HSA-939182)
0.806
5
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.785
5
UniProt:Q14596 NBR1
0.784
7
UniProt:P58004 SESN2
1
SESN2 [cytosol]
(R-HSA-5629143)
0.728
9
UniProt:Q9BXW4 MAP1LC3C
3
MAP1LC3C [autophagosome membrane]
(R-HSA-5683638)
MAP1LC3C(1-147) [cytosol]
(R-HSA-5682653)
MAP1LC3C [cytosol]
(R-HSA-5679223)
0.702
3
UniProt:Q9Y4K3 TRAF6
8
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [plasma membrane]
(R-HSA-936955)
TRAF6 [endosome membrane]
(R-HSA-450272)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
0.688
4
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.649
8
UniProt:P54725 RAD23A
1
RAD23A [nucleoplasm]
(R-HSA-5688076)
0.635
3
UniProt:Q15038 DAZP2
0.621
3
UniProt:P11473 VDR
2
VDR [nucleoplasm]
(R-HSA-375512)
SUMO2-VDR [nucleoplasm]
(R-HSA-4546376)
0.591
4
UniProt:Q6IRU7
1
CEP78 [cytosol]
(R-MMU-380304)
0.564
2
UniProt:Q15334 L2GL1
0.564
2
UniProt:Q96CV9 OPTN
4
p-S177-OPTN [cytosol]
(R-HSA-2562525)
OPTN [Golgi membrane]
(R-HSA-2161111)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
OPTN [recycling endosome membrane]
(R-HSA-8854141)
0.558
7
UniProt:P12709
4
GPI [extracellular region]
(R-SCE-6806478)
GPI [secretory granule lumen]
(R-SCE-6801495)
GPI [ficolin-1-rich granule lumen]
(R-SCE-6801506)
GPI [cytosol]
(R-SCE-70468)
0.556
3
UniProt:Q2V2M9 FHOD3
0.543
6
UniProt:Q2V2M9-4 FHOD3
0.543
4
UniProt:P84022 SMAD3
12
p-S423,S425-SMAD3 D258N [cytosol]
(R-HSA-3315470)
Ub-SMAD3 [cytosol]
(R-HSA-6782830)
p-S423,S425-SMAD3 R268C [cytosol]
(R-HSA-3315075)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-177104)
p-S423,S425-SMAD3 [cytosol]
(R-HSA-171184)
SMAD3 [cytosol]
(R-HSA-170855)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
SMAD3 [nucleoplasm]
(R-HSA-206150)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
0.543
3
UniProt:O95817 BAG3
1
BAG3 [cytosol]
(R-HSA-5255451)
0.537
3
UniProt:Q9UDY8 MALT1
1
MALT1 [cytosol]
(R-HSA-202461)
0.524
2
UniProt:Q96B97 SH3KBP1
3
SH3KBP1 [cytosol]
(R-HSA-182957)
SH3KBP1 [plasma membrane]
(R-HSA-182955)
Ub-SH3KBP1 [cytosol]
(R-HSA-182926)
0.524
4
UniProt:Q9Y6K9 IKBKG
12
IKBKG [nucleoplasm]
(R-HSA-4755413)
SUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wro*447 [cytosol]
(R-HSA-5262978)
IKBKG [cytosol]
(R-HSA-168108)
K63polyUb-NEMO [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
0.524
2
UniProt:P38182
12
MAP1LC3C(1-147) [cytosol]
(R-SCE-5682653)
MAP1LC3A(1-121) [cytosol]
(R-SCE-5682681)
MAP1LC3B(2-121) [cytosol]
(R-SCE-5682674)
GABARAP(1-117) [cytosol]
(R-SCE-5682696)
MAP1LC3B [autophagosome membrane]
(R-SCE-5683641)
MAP1LC3A [autophagosome membrane]
(R-SCE-5683640)
MAP1LC3C [autophagosome membrane]
(R-SCE-5683638)
GABARAP [autophagosome membrane]
(R-SCE-5683634)
MAP1LC3C [cytosol]
(R-SCE-5679223)
GABARAP [cytosol]
(R-SCE-975521)
MAP1LC3B [cytosol]
(R-SCE-5205651)
MAP1LC3A [cytosol]
(R-SCE-5205676)
0.508
3
UniProt:P12504 VIF
0.499
2
UniProt:O70405
7
phospho-p-S317,467,556,638,T575-ULK1 [cytosol]
(R-MMU-5673747)
ULK1 [recycling endosome]
(R-MMU-8854761)
phospho-p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol]
(R-MMU-5675858)
phospho-p-S758-ULK1 [cytosol]
(R-MMU-5672131)
phospho-p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane]
(R-MMU-8948047)
ULK1 [mitochondrial outer membrane]
(R-MMU-8948145)
ULK1 [cytosol]
(R-MMU-1632847)
0.499
2
UniProt:P04629 NTRK1
4
NTRK1 [Golgi membrane]
(R-HSA-3008805)
p-5Y-NTRK1 [Golgi membrane]
(R-HSA-3008810)
NTRK1 [plasma membrane]
(R-HSA-3008784)
p-5Y-NTRK1 [plasma membrane]
(R-HSA-3009413)
0.499
2
UniProt:Q13163 MAP2K5
1
MAP2K5 [cytosol]
(R-HSA-198722)
0.488
2
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