CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol

Stable Identifier
R-HSA-193792
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
5beta-cholestan-3alpha,7alpha,24(S)-triol is hydroxylated to 5beta-cholestan-3alpha,7alpha,24(S), 27-tetrol, 5beta-cholestan-3alpha,7alpha,24(S)-triol + NADPH + H+ + O2 => 5beta-cholestan-3alpha,7alpha,24(S),27-tetrol + NADP+ + H2O
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

5β-cholestan-3α,7α,24(S)-triol, NADPH + H+, and O2 react to form 5β-cholestan-3α,7α,24(S),27-tetrol, NADP+, and H2O. This reaction occurs in the mitochondrial matrix, catalyzed by CYP27A1.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
steroid hydroxylase activity of CYP27A1 [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
Cite Us!