3,7,24THCA is translocated from the mitochondrial matrix to the cytosol

Stable Identifier
R-HSA-193786
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
3,7,24THCA [mitochondrial matrix] => 3,7,24THCA [cytosol]
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3,7,24THCA (3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate) is translocated from the mitochondrial matrix to the cytosol. The transporter that mediates its passage across the inner mitochondrial membrane has not been identified (Russell 2003). VLCS (SLC27A2), one of the enzymes that catalyzes CoA conjugation of 3,7,24THCA, may also be present in peroxisomes, and Mihalik et al. (2002) have hypothesized that 3,7,24THCA could be translocated unchanged from the mitochondrial matrix to the peroxisomal matrix and undergo conjugation there.

Literature References
PubMed ID Title Journal Year
12543708 The enzymes, regulation, and genetics of bile acid synthesis

Russell, DW

Annu Rev Biochem 2003
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