Efflux of 24-hydroxycholesterol

Stable Identifier
R-HSA-193776
Type
Reaction [transition]
Species
Homo sapiens
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24-hydroxycholesterol is transported from the endoplasmic reticulum to the extracellular space. In humans, this event is the major source of 24-hydroxycholesterol in the blood and is the means by which the molecule, generated from cholesterol in the brain, is transported to the liver for conversion to bile acids and bile salts. While transport proteins are likely to play a role in this process, and the 24-hydroxycholesterol is likely to occur as part of a lipoprotein complex in the blood, the relevant proteins have not been identified (Lutjohann et al. 1996; Bjorkhem et al. 1998).

Literature References
PubMed ID Title Journal Year
8790411 Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation

Lutjohann, D, Breuer, O, Ahlborg, G, Nennesmo, I, Siden, A, Diczfalusy, U, Bjorkhem, I

Proc Natl Acad Sci U S A 1996
9717719 Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation

Bjorkhem, I, Lutjohann, D, Diczfalusy, U, Stahle, L, Ahlborg, G, Wahren, J

J Lipid Res 1998
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