5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol

Stable Identifier
R-HSA-193758
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
5beta-cholestan-7alpha,24(S)-diol-3-one+ NADPH + H+ => 5beta-cholestan-3alpha,7alpha,24(S)-triol + NADP+
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5Beta-cholesten-7alpha,24(S)-diol-3-one and NADPH + H+ form 5beta-cholestan-3alpha,7alpha,24(S)-triol and NAPDP+. The reaction is catalyzed by 3alpha-hydroxysteroid dehydrogenase (AKR1C4), a cytosolic enzyme belonging to the aldo-keto reductase family (Dufort et al. 2001). Biochemical studies with rat proteins raise the possibility that other related enzymes may also carry out this reaction in vivo (Russell 2003).

Literature References
PubMed ID Title Journal Year
11158055 Human types 1 and 3 3 alpha-hydroxysteroid dehydrogenases: differential lability and tissue distribution

Dufort, I

J Clin Endocrinol Metab 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
aldo-keto reductase (NADP) activity of Aldo-keto reductase family [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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