Reactome | Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA

Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA

Stable Identifier

R-HSA-193736

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal matrix

Synonyms

3,7,24THCA-CoA => (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA

ReviewStatus

5/5

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The isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA, catalyzed by 2-methylacyl-CoA racemase, occurs in the peroxisomal matrix.

Literature References

PubMed ID	Title	Journal	Year
10655068	Mutations in the gene encoding peroxisomal alpha-methylacyl-CoA racemase cause adult-onset sensory motor neuropathy Ferdinandusse, S, Denis, S, Clayton, PT, Graham, A, Rees, JE, Allen, JT, McLean, BN, Brown, AY, Vreken, P, Waterham, HR, Wanders, RJA	Nat Genet	2000
11060344	Mitochondrial and peroxisomal targeting of 2-methylacyl-CoA racemase in humans Amery, L, Fransen, M, De Nys, K, Mannaerts, GP, Van Veldhoven, PP	J Lipid Res	2000
7649182	Purification and characterization of an alpha-methylacyl-CoA racemase from human liver Schmitz, W, Albers, C, Fingerhut, R, Conzelmann, E	Eur J Biochem	1995