Sterol 12alpha hydroxylase (CYP8B1) catalyses the 12-alpha-hydroxylation of 4-cholesten-7alpha,24(S)-diol-3-one (4CHOL7a,24(S)DONE) to 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one (4CHOL7a,12a,24(S)TONE). While the human gene has been cloned (Gafvels et al. 1999), its protein product has not been characterised, and the enzymatic properties of human CYP8B1 protein are inferred from those of its well-characterised rabbit homolog (Ishida et al. 1992).
Coon, MJ, Ishida, H, Okuda, K, Noshiro, M
Gafvels, M, Bjorkhem, I, Jansson, M, Raudsepp, T, Chowdhary, BP, Andersson, U, Persson, B, Eggertsen, G, Olin, M
7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity of Cytochrome P450 (CYP8B1 based) [endoplasmic reticulum membrane]
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