Part of the ICD migrates to the nucleus

Stable Identifier
R-HSA-193702
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nuclear envelope
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Part of the ICD migrates to the nucleus
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

A portion of the p75NTR ICD produced by gamma-secretase cleavage moves to the nucleus where it may participate in transcriptional regulation.

Literature References
PubMed ID Title Journal Year
12843241 Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability

Kanning, KC, Hudson, M, Amieux, PS, Wiley, JC, Bothwell, M, Schecterson, LC

J Neurosci 2003
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
Part of the ICD migrates to the nucleus (Bos taurus)
Part of the ICD migrates to the nucleus (Canis familiaris)
Part of the ICD migrates to the nucleus (Danio rerio)
Part of the ICD migrates to the nucleus (Mus musculus)
Part of the ICD migrates to the nucleus (Rattus norvegicus)
Part of the ICD migrates to the nucleus (Sus scrofa)
Part of the ICD migrates to the nucleus (Xenopus tropicalis)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Friedman, WJ  (2008-05-20)
Chao, MV  (2008-05-28)
Created
Jassal, B  (2007-02-23)