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p75NTR regulates axonogenesis
Stable Identifier
R-HSA-193697
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
p75NTR regulates axonogenesis (Homo sapiens)
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p75NTR modulates axonal growth by regulating the activity of small GTPases like RHOA and RHOB, that control the state of actin polymerization. The best studied is RHOA. In its active, GTP-bound form, RHOA rigidifies the actin cytoskeleton, thereby inhibiting axonal elongation and causing growth cone collapse. Depending on the ligand that binds to it, p75NTR can either promote or inhibit axonal growth, Neurotrophin binding leads to inhibition of RHOA activity and axonal growth. Axonal growth inhibition is caused by myelin molecules named MDGIs (myelin-derived growth inhibitors), such as NOGO, MAG, OMGP. MDGIs bind to a complex made up of p75NTR and the NOGO receptor, causing RHOA activation and axonal growth inhibition.
Literature References
PubMed ID
Title
Journal
Year
17335080
Roles of glial p75NTR in axonal regeneration
Li, HY
,
Zhou, XF
J Neurosci Res
2007
Participants
Events
Axonal growth stimulation
(Homo sapiens)
Axonal growth inhibition (RHOA activation)
(Homo sapiens)
Participates
as an event of
p75 NTR receptor-mediated signalling (Homo sapiens)
Event Information
Go Biological Process
regulation of axonogenesis (0050770)
Orthologous Events
p75NTR regulates axonogenesis (Bos taurus)
p75NTR regulates axonogenesis (Caenorhabditis elegans)
p75NTR regulates axonogenesis (Canis familiaris)
p75NTR regulates axonogenesis (Danio rerio)
p75NTR regulates axonogenesis (Drosophila melanogaster)
p75NTR regulates axonogenesis (Gallus gallus)
p75NTR regulates axonogenesis (Mus musculus)
p75NTR regulates axonogenesis (Rattus norvegicus)
p75NTR regulates axonogenesis (Sus scrofa)
p75NTR regulates axonogenesis (Xenopus tropicalis)
Authored
Nasi, S (2006-10-10)
Annibali, D (2006-10-10)
Reviewed
Friedman, WJ (2008-05-20)
Chao, MV (2008-05-28)
Created
Jassal, B (2007-02-23)
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