Sphingomyelinase is activated by the NGF:p75NTR complex

Stable Identifier
R-HSA-193672
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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NGF binding to p75NTR activates N-SMase (Neutral sphingomyelinase), and possibly A-SMase (acid sphingomyelinase), an enzyme that converts sphingomyelin to ceramide. The mode and mechanism of interaction between p75 and N-SMase have not been determined but is thought to involve the recruitment of Mg2+ to the active site of the enzyme.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
transmembrane signaling receptor activity of mature NGF homodimer:p75NTR [plasma membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created