Sphingomyelinase is activated by the NGF:p75NTR complex

Stable Identifier
R-HSA-193672
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Sphingomyelinase is activated by the NGF:p75NTR complex
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NGF binding to p75NTR activates N-SMase (Neutral sphingomyelinase), and possibly A-SMase (acid sphingomyelinase), an enzyme that converts sphingomyelin to ceramide. The mode and mechanism of interaction between p75 and N-SMase have not been determined but is thought to involve the recruitment of Mg2+ to the active site of the enzyme.

Participants
Input
Output
Participates
as an event of
Catalyst Activity

transmembrane signaling receptor activity of mature NGF homodimer:p75NTR [plasma membrane]

Physical Entity
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
Activity
transmembrane signaling receptor activity (GO:0004888)
Inferred From
Sphingomyelinase is activated by the NGF:p75NTR complex (Rattus norvegicus)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Friedman, WJ  (2008-05-20)
Chao, MV  (2008-05-28)
Created
Jassal, B  (2007-02-23)
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