Myelin components can interact with p75NTR:NgR:LINGO1

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

A group of myelin components named MDGIs (myelin-derived growth-inhibitors), bind to NgR and inhibit neurite outgrowth. Examples of such components are NOGO, OMGP (oligodendrocyte myelin glycoprotein) and MAG (myelin-associated glycoprotein). The amino-terminal region of NgR, covering eight leucine-rich repeats (LRR) and the LRR carboxy-terminal domain (LRRCT) is sufficient to interact with MAG, OMGP and NOGO. Their binding to NgR enhances the NgR-p75 interaction.These inhibitors bind to a receptor complex made up of the NOGO receptor, NgR, and p75NTR. Such complexes then activate RHOA, thereby inhibiting axonal growth.

Literature References
PubMed ID Title Journal Year
12426574 A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein

Wong, ST, Henley, JR, Kanning, KC, Huang, KH, Bothwell, M, Poo, MM

Nat Neurosci 2002
Participant Of
Orthologous Events
Cite Us!