NGF binding to p75NTR inactivates RHOA

Stable Identifier
R-HSA-193646
Type
Reaction [binding]
Species
Homo sapiens
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Neurotrophin (NGF or BDNF) binding to p75NTR increases RHO-GDI activity, possibly by loosening the grip of p75NTR on RHO-GDI, which prevents the dissociation of GDP thus allowing axonal growth to occur (Gehler et al. 2004).

Literature References
PubMed ID Title Journal Year
15128850 p75 neurotrophin receptor signaling regulates growth cone filopodial dynamics through modulating RhoA activity

Gehler, S, Gallo, G, Veien, E, Letourneau, PC

J Neurosci 2004
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