p75NTR interacts with the NOGO receptor

Stable Identifier
R-HSA-193636
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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p75NTR interacts with the NOGO receptor
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The p75NTR extracellular domain interacts with NOGO receptor (NgR), a glycosyl phosphatidylinositol (GPI)-anchored protein present as a homomultimer at the cell surface. As NgR lacks an intracellular domain, it utilizes p75NTR as a co-receptor for intracellular signalling.

Literature References
PubMed ID Title Journal Year
11201742 Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration

Strittmatter, SM, Fournier, AE, GrandPre, T

Nature 2001
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Orthologous Events
p75NTR interacts with the NOGO receptor (Xenopus tropicalis)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Friedman, WJ  (2008-05-20)
Chao, MV  (2008-05-28)
Created
Jassal, B  (2007-02-23)
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