(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA

Stable Identifier
R-HSA-193455
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA + NAD+ => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + NADH + H+
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(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA and NAD+ react to form 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, NADH, and H+. This oxidation reaction, catalyzed by the peroxisomal D-bifunctional enzyme (Huyghe et al. 2006), occurs in the peroxisomal matrix.

Literature References
PubMed ID Title Journal Year
8902629 Purification and properties of human D-3-hydroxyacyl-CoA dehydratase: medium-chain enoyl-CoA hydratase is D-3-hydroxyacyl-CoA dehydratase

Jiang, LL, Kobayashi, A, Matsuura, H, Fukushima, H, Hashimoto, T

J Biochem (Tokyo) 1996
Participants
Participates
Catalyst Activity

3-hydroxyacyl-CoA dehydrogenase activity of HSD17B4 dimer [peroxisomal matrix]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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