CYP17A1 17-hydroxylates P4 to 17aHPROG

Stable Identifier
R-HSA-193072
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Hydroxylation of progesterone to form 17alpha-hydroxyprogesterone, progesterone + NADPH + H+ + O2 => 17alpha-hydroxyprogesterone + NADP+ + H2O
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Progesterone (P4), NADPH + H+, and O2 react to form 17alpha-hydroxyprogesterone (17aHPROG), NADP+, and H2O. This reaction is catalyzed by steroid 17 alpha hydroxylase/17,20 lyase (CYP17A1), associated with the endoplasmic reticulum membrane.

Literature References
Participants
Participates
Catalyst Activity

steroid 17-alpha-monooxygenase activity of CYP17A1 [endoplasmic reticulum membrane]

Orthologous Events
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