CYP17A1 17-hydroxylates P4 to 17aHPROG

Stable Identifier
R-HSA-193072
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
Synonyms
Hydroxylation of progesterone to form 17alpha-hydroxyprogesterone, progesterone + NADPH + H+ + O2 => 17alpha-hydroxyprogesterone + NADP+ + H2O
ReviewStatus
5/5
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CYP17A1 17-hydroxylates P4 to 17aHPROG
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Progesterone (P4), NADPH + H+, and O2 react to form 17alpha-hydroxyprogesterone (17aHPROG), NADP+, and H2O. This reaction is catalyzed by steroid 17 alpha hydroxylase/17,20 lyase (CYP17A1), associated with the endoplasmic reticulum membrane.
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Output
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as an event of
Catalyst Activity

steroid 17-alpha-monooxygenase activity of CYP17A1 [endoplasmic reticulum membrane]

Physical Entity
CYP17A1 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
steroid 17-alpha-monooxygenase activity (GO:0004508)
Orthologous Events
CYP17A1 17-hydroxylates P4 to 17aHPROG (Bos taurus)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Canis familiaris)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Danio rerio)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Gallus gallus)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Mus musculus)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Rattus norvegicus)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Sus scrofa)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Xenopus tropicalis)
Authored
Jassal, B  (2008-10-01)
Reviewed
D'Eustachio, P  (2007-04-21)
Created
Jassal, B  (2007-02-13)
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