The 17HSD family of enzymes catalyze the final step in the synthesis of estradiol and testosterone. They convert inactive 17-ketosteroids to their active 17beta-hydroxy forms. Androstenedione, a ketosteroid, is reduced to testosterone, a highly potent androgen, by the enzyme 17beta-hydroxysteroid dehydrogenase isoform III (17HSD3). The other human isoforms of 17HSDs to take part in the final steps of active steroid biosynthesis are types 1 and VII, which reduce estrone to estradiol.Corticotropin (Adrenocorticotropic hormone, ACTH) acts through the ACTH receptor called melanocortin receptor type 2 (MC2R) to stimulate steroidogenesis, increasing the production of androgens (McKenna et al, 1997).In males, Lutropin (LH) stimulates testosterone production.
McKenna, TJ, Fearon, U, Clarke, D, Cunningham, SK
Luu-The, V, Zhang, Y, Poirier, D, Labrie, F
Luu-The, V, Labrie, C, Zhao, HF, Couet, J, Lachance, Y, Simard, J, Cote, J, Leblanc, G, Lagace, L, Berube, D, Gagne, R, Labrie, F
Geissler, WM, Davis, DL, Wu, L, Bradshaw, KD, Patel, S, Mendonca, BB, Elliston, KO, Wilson, JD, Russell, DW, Andersson, S
testosterone dehydrogenase [NAD(P)] activity of HSD17B3-like Proteins [endoplasmic reticulum membrane]
In females, lutropin (LH) can trigger ovulation whereas in males it stimulates testosterone production, as shown here.
Corticotropin (Adrenocorticotropic hormone, ACTH) acts through the ACTH receptor called melanocortin receptor type 2 (MC2R) to stimulate steroidogenesis, increasing the production of androgens (McKenna et al, 1997).
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