The 17HSD family of enzymes catalyze the final step in the synthesis of estradiol and testosterone. They convert inactive 17-ketosteroids to their active 17beta-hydroxy forms. Androstenedione, a ketosteroid, is reduced to testosterone, a highly potent androgen, by the enzyme 17beta-hydroxysteroid dehydrogenase isoform III (17HSD3). The other human isoforms of 17HSDs to take part in the final steps of active steroid biosynthesis are types 1 and VII, which reduce estrone to estradiol.Corticotropin (Adrenocorticotropic hormone, ACTH) acts through the ACTH receptor called melanocortin receptor type 2 (MC2R) to stimulate steroidogenesis, increasing the production of androgens (McKenna et al, 1997).In males, Lutropin (LH) stimulates testosterone production. In females, lutropin (LH) can trigger ovulation.
Poirier, D, Luu-The, V, Labrie, F, Zhang, Y
Fearon, U, Clarke, D, McKenna, TJ, Cunningham, SK
Simard, J, Lagace, L, Lachance, Y, Cote, J, Luu-The, V, Labrie, F, Gagne, R, Berube, D, Leblanc, G, Labrie, C, Couet, J, Zhao, HF
Bradshaw, KD, Andersson, S, Geissler, WM, Russell, DW, Wilson, JD, Patel, S, Davis, DL, Mendonca, BB, Wu, L, Elliston, KO
testosterone dehydrogenase [NAD(P)] activity of HSD17B3-like Proteins [endoplasmic reticulum membrane]
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