HSD17B3-like proteins reducde ANDST to TEST

Stable Identifier
Reaction [transition]
Homo sapiens
Reduction of androstenedione to testosterone
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The 17HSD family of enzymes catalyze the final step in the synthesis of estradiol and testosterone. They convert inactive 17-ketosteroids to their active 17beta-hydroxy forms. Androstenedione, a ketosteroid, is reduced to testosterone, a highly potent androgen, by the enzyme 17beta-hydroxysteroid dehydrogenase isoform III (17HSD3). The other human isoforms of 17HSDs to take part in the final steps of active steroid biosynthesis are types 1 and VII, which reduce estrone to estradiol.
Corticotropin (Adrenocorticotropic hormone, ACTH) acts through the ACTH receptor called melanocortin receptor type 2 (MC2R) to stimulate steroidogenesis, increasing the production of androgens (McKenna et al, 1997).
In males, Lutropin (LH) stimulates testosterone production. In females, lutropin (LH) can trigger ovulation.

Literature References
PubMed ID Title Journal Year
8547185 Characteristics of human types 1, 2 and 3 17 beta-hydroxysteroid dehydrogenase activities: oxidation/reduction and inhibition

Poirier, D, Luu-The, V, Labrie, F, Zhang, Y

J Steroid Biochem Mol Biol 1995
9536209 A critical review of the origin and control of adrenal androgens

Fearon, U, Clarke, D, McKenna, TJ, Cunningham, SK

Baillieres Clin Obstet Gynaecol 1997
2197970 Purification, cloning, complementary DNA structure, and predicted amino acid sequence of human estradiol 17 beta-dehydrogenase

Simard, J, Lagace, L, Lachance, Y, Cote, J, Luu-The, V, Labrie, F, Gagne, R, Berube, D, Leblanc, G, Labrie, C, Couet, J, Zhao, HF

Ann N Y Acad Sci 1990
8075637 Male pseudohermaphroditism caused by mutations of testicular 17 beta-hydroxysteroid dehydrogenase 3

Bradshaw, KD, Andersson, S, Geissler, WM, Russell, DW, Wilson, JD, Patel, S, Davis, DL, Mendonca, BB, Wu, L, Elliston, KO

Nat Genet 1994
Catalyst Activity

testosterone dehydrogenase [NAD(P)] activity of HSD17B3-like Proteins [endoplasmic reticulum membrane]

This event is regulated
Positively by