Oxidation of cholesterol to 22beta-hydroxycholesterol

Stable Identifier
R-HSA-193054
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
cholesterol + NADPH + H+ => 22beta-hydroxycholesterol + NADP+ + H2O, Oxidation of cholesterol
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cholesterol and NADPH + H+ react to form 22beta-hydroxycholesterol, NADP+, and H2O, catalyzed by CYP11A (P450scc) associated with the inner mitochondrial membrane.

Literature References
PubMed ID Title Journal Year
9578606 Expression of catalytically active human cytochrome p450scc in Escherichia coli and mutagenesis of isoleucine-462

Woods, ST, Sadleir, J, Downs, T, Triantopoulos, T, Headlam, MJ, Tuckey, RC

Arch Biochem Biophys 1998
3024157 Human cholesterol side-chain cleavage enzyme, P450scc: cDNA cloning, assignment of the gene to chromosome 15, and expression in the placenta

Chung, BC, Matteson, KJ, Voutilainen, R, Mohandas, TK, Miller, WL

Proc Natl Acad Sci U S A 1986
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cholesterol monooxygenase (side-chain-cleaving) activity of CYP11A1:FDXR:FDX1,FDX1L (red.) [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
Cite Us!