Reactome | Oxidation of cholesterol to 22beta-hydroxycholesterol

Oxidation of cholesterol to 22beta-hydroxycholesterol

Stable Identifier

R-HSA-193054

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix, mitochondrial inner membrane

Synonyms

cholesterol + NADPH + H+ => 22beta-hydroxycholesterol + NADP+ + H2O, Oxidation of cholesterol

ReviewStatus

5/5

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Oxidation of cholesterol to 22beta-hydroxycholesterol

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Cholesterol and NADPH + H+ react to form 22beta-hydroxycholesterol, NADP+, and H2O, catalyzed by CYP11A (P450scc) associated with the inner mitochondrial membrane.

Literature References

PubMed ID	Title	Journal	Year
3024157	Human cholesterol side-chain cleavage enzyme, P450scc: cDNA cloning, assignment of the gene to chromosome 15, and expression in the placenta Miller, WL, Chung, BC, Voutilainen, R, Mohandas, TK, Matteson, KJ	Proc Natl Acad Sci U S A	1986
9578606	Expression of catalytically active human cytochrome p450scc in Escherichia coli and mutagenesis of isoleucine-462 Downs, T, Tuckey, RC, Woods, ST, Triantopoulos, T, Sadleir, J, Headlam, MJ	Arch Biochem Biophys	1998