Export of Spliced Viral mRNA

Stable Identifier
Reaction [transition]
Homo sapiens
Related Species
Influenza A virus
Locations in the PathwayBrowser
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In the cases of spliced, polyadenylated mRNA transcribed from M (segment 7) and NS (segment 8) vRNA templates (producing the spliced mRNA for M2 and NS2/NEP, respectively), export may be coupled to aspects of the cellular splicing and export mechanisms (Chen, 2000; Alonso-Caplan et al, 1992; Amorim, 2006). Simultaneously, the export of cellular mRNA appear to be inhibited by the viral NS1 protein, which binds to the cellular cleavage and polyadenylation specificity factor (CPSF), preventing polyadenylation and completion of pre-mRNA processing (Nemerof et al., 1998; Fortes, 1994; Lu, 1994; Li, 2001).

Literature References
PubMed ID Title Journal Year
1531330 Nucleocytoplasmic transport: the influenza virus NS1 protein regulates the transport of spliced NS2 mRNA and its precursor NS1 mRNA

Qiu, Y, Krug, RM, Alonso-Caplen, FV, Nemeroff, ME

Genes Dev 1992
10920397 Selective nuclear export of viral mRNAs in influenza-virus-infected cells

Chen, Z, Krug, RM

Trends Microbiol 2000
Catalyst Activity

structural constituent of nuclear pore activity of Nuclear Pore Complex (NPC) [nuclear envelope]

Name Identifier Synonyms
influenza DOID:8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
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