Export of Spliced Viral mRNA

Stable Identifier
R-HSA-192925
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
Locations in the PathwayBrowser
General
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In the cases of spliced, polyadenylated mRNA transcribed from M (segment 7) and NS (segment 8) vRNA templates (producing the spliced mRNA for M2 and NS2/NEP, respectively), export may be coupled to aspects of the cellular splicing and export mechanisms (Chen, 2000; Alonso-Caplan et al, 1992; Amorim, 2006). Simultaneously, the export of cellular mRNA appear to be inhibited by the viral NS1 protein, which binds to the cellular cleavage and polyadenylation specificity factor (CPSF), preventing polyadenylation and completion of pre-mRNA processing (Nemerof et al., 1998; Fortes, 1994; Lu, 1994; Li, 2001).

Literature References
PubMed ID Title Journal Year
10920397 Selective nuclear export of viral mRNAs in influenza-virus-infected cells

Chen, Z, Krug, RM

Trends Microbiol 2000
1531330 Nucleocytoplasmic transport: the influenza virus NS1 protein regulates the transport of spliced NS2 mRNA and its precursor NS1 mRNA

Alonso-Caplen, FV, Nemeroff, ME, Qiu, Y, Krug, RM

Genes Dev 1992
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
structural constituent of nuclear pore activity of Nuclear Pore Complex (NPC) [nuclear envelope]
Physical Entity
Activity
Disease
Name Identifier Synonyms
influenza 8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Authored
Reviewed
Created
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