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About
What is Reactome ?
News
Team
Scientific Advisory Board
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Release Calendar
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Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
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How do I search ?
Details Panel
Analysis Tools
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Analysis Gene Expression
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Diseases
Cytomics
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FAQ
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Analyse gene expression
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HSP90AA1 [cytosol]
Stable Identifier
R-HSA-192864
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
HSP90
Icon
Locations in the PathwayBrowser for interactor UniProt:P51451 BLK
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Uptake and actions of bacterial toxins (Homo sapiens)
Uptake and function of diphtheria toxin (Homo sapiens)
DT fragment B transports DT fragment A from target cell endosome membrane (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Influenza Infection (Homo sapiens)
Influenza Viral RNA Transcription and Replication (Homo sapiens)
vRNP Assembly (Homo sapiens)
Viral Polymerase Assembly (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of nitric oxide: NOS3 activation and regulation (Homo sapiens)
eNOS activation (Homo sapiens)
HSP90 binds eNOS:Caveolin-1:CaM complex (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
HSP90AA1 binds p-6Y-VEGFR2 (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
VEGFR2 mediated vascular permeability (Homo sapiens)
HSP90 binds eNOS:Caveolin-1:CaM complex (Homo sapiens)
HSP90AA1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P07900 HSP90AA1
Gene Names
HSP90AA1, HSP90A, HSPC1, HSPCA
Chain
initiator methionine:, chain:2-732
Reference Genes
BioGPS Gene:3320 HSP90AA1
COSMIC (genes):HSP90AA1 HSP90AA1
CTD Gene:3320 HSP90AA1
dbSNP Gene:3320 HSP90AA1
ENSEMBL:ENSG00000080824 HSP90AA1
ENSEMBL_homo_sapiens_GENE:ENSG00000080824.19 HSP90AA1
HGNC:5253 HSP90AA1
KEGG Gene (Homo sapiens):3320 HSP90AA1
Monarch:3320 HSP90AA1
NCBI Gene:3320 HSP90AA1
OMIM:140571 HSP90AA1
UCSC:P07900 HSP90AA1
Reference Transcript
RefSeq:NM_001017963.2 HSP90AA1
RefSeq:NM_005348.3 HSP90AA1
Other Identifiers
11732996_at
11749934_s_at
11758308_s_at
16796829
210211_PM_s_at
210211_s_at
211968_PM_s_at
211968_s_at
211969_PM_at
211969_at
214328_PM_s_at
214328_s_at
2362304
2545387
2751645
2755868
2755880
2793561
2793563
2793567
32316_s_at
3320
3367313
3367314
3367315
3367316
3367317
3367319
3367320
3367322
3367324
3367325
3367327
3367328
3367329
3580178
3580180
3580181
3580182
3580184
3580185
3580187
3580188
3580190
3580192
3580194
3580196
3580197
3580198
3580200
3580203
3580204
3580207
3580208
3580210
3580211
3580219
3580230
7981335
A_23_P162866
A_23_P162874
A_33_P3665777
GE59722
GO:0000166
GO:0001764
GO:0001934
GO:0002134
GO:0002135
GO:0002218
GO:0002230
GO:0002376
GO:0003009
GO:0003012
GO:0003013
GO:0003723
GO:0003729
GO:0003824
GO:0005515
GO:0005524
GO:0005525
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005764
GO:0005773
GO:0005829
GO:0005886
GO:0005929
GO:0006457
GO:0006839
GO:0006886
GO:0006913
GO:0006914
GO:0006986
GO:0007004
GO:0007005
GO:0008092
GO:0009408
GO:0009409
GO:0009410
GO:0009651
GO:0009986
GO:0010592
GO:0010659
GO:0012501
GO:0016020
GO:0016323
GO:0016324
GO:0016787
GO:0016887
GO:0017098
GO:0019903
GO:0023026
GO:0030154
GO:0030163
GO:0030235
GO:0030312
GO:0030911
GO:0031012
GO:0031396
GO:0031410
GO:0031526
GO:0031625
GO:0032200
GO:0032273
GO:0032564
GO:0032728
GO:0032880
GO:0032991
GO:0034605
GO:0034774
GO:0036126
GO:0036211
GO:0042026
GO:0042220
GO:0042307
GO:0042470
GO:0042802
GO:0042803
GO:0042826
GO:0042981
GO:0043025
GO:0043202
GO:0043209
GO:0043226
GO:0043254
GO:0043335
GO:0043627
GO:0044183
GO:0044294
GO:0044295
GO:0044325
GO:0045040
GO:0045429
GO:0045732
GO:0045793
GO:0046677
GO:0048156
GO:0048471
GO:0048856
GO:0048870
GO:0050821
GO:0050877
GO:0051020
GO:0051022
GO:0051082
GO:0051131
GO:0051973
GO:0060452
GO:0061024
GO:0061684
GO:0062023
GO:0065003
GO:0070062
GO:0070182
GO:0071682
GO:0097110
GO:0097226
GO:0097524
GO:0097718
GO:0098542
GO:0098586
GO:0098772
GO:0099072
GO:0140657
GO:0140662
GO:1902949
GO:1904813
GO:1905323
GO:1990782
HMNXSV003006689
Hs.289088.4.A1_3p_at
Hs.289088.4.A2_3p_a_at
ILMN_1691097
ILMN_2373515
PH_hs_0033549
TC14001526.hg
TC14002169.hg
X15183_at
g3287488_3p_a_at
Participates
as a component of
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
FKBP6:HSP90AA1 [cytosol] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
Nlp-depleted centrosome [cytosol] (Homo sapiens)
centrosome containing phosphorylated Nlp [cytosol] (Homo sapiens)
cNAP-1 depleted centrosome [cytosol] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
as a member of
STAT3-upregulated cytosolic proteins [cytosol] (Homo sapiens)
HSP90AA1,HSP90AB1 [cytosol] (Homo sapiens)
as an input of
HSP90 binds eNOS:Caveolin-1:CaM complex (Homo sapiens)
HSP90AA1 binds p-6Y-VEGFR2 (Homo sapiens)
This entity regulates
Positively
DT fragment B transports DT fragment A from target cell endosome membrane
(Homo sapiens)
Viral Polymerase Assembly
(Homo sapiens)
Other forms of this molecule
HSP90AA1 [secretory granule lumen]
HSP90AA1 [ficolin-1-rich granule lumen]
HSP90AA1 [plasma membrane]
HSP90AA1 [endocytic vesicle lumen]
HSP90AA1 [extracellular region]
HSP90AA1 [nucleoplasm]
HSP90AA1 [lysosomal lumen]
Inferred To
Homologues of HSP90AA1 [cytosol]
(Plasmodium falciparum)
Homologues of HSP90AA1 [cytosol]
(Saccharomyces cerevisiae)
Homologues of HSP90AA1 [cytosol]
(Sus scrofa)
hsp90aa1.1 [cytosol]
(Xenopus tropicalis)
hsp90aa1.2 [cytosol]
(Danio rerio)
HSP90AA1 [cytosol]
(Bos taurus)
HSP90AA1 [cytosol]
(Caenorhabditis elegans)
HSP90AA1 [cytosol]
(Canis familiaris)
HSP90AA1 [cytosol]
(Dictyostelium discoideum)
HSP90AA1 [cytosol]
(Drosophila melanogaster)
HSP90AA1 [cytosol]
(Gallus gallus)
HSP90AA1 [cytosol]
(Mus musculus)
HSP90AA1 [cytosol]
(Plasmodium falciparum)
HSP90AA1 [cytosol]
(Rattus norvegicus)
HSP90AA1 [cytosol]
(Saccharomyces cerevisiae)
HSP90AA1 [cytosol]
(Schizosaccharomyces pombe)
HSP90AA1 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_005339.3
,
NP_001017963.2
Guide to Pharmacology - Targets
2905
OpenTargets
ENSG00000080824
ZINC - Substances
HS90A_HUMAN
ZINC target
P07900
ZINC - Biogenic
HS90A_HUMAN
PRO
P07900
PDB
2CCS
,
3RLP
,
2BUG
,
6EL5
,
4AWP
,
4O0B
,
2WI1
,
2YEG
,
4XIR
,
3VHC
,
2YI0
,
2WI2
,
4L90
,
4CWQ
,
4BQG
,
8W8K
,
1UYG
,
3D0B
,
6GR5
,
7S98
,
2BZ5
,
4R3M
,
4EFT
,
5XQE
,
6GPF
,
6FDP
,
4O04
,
5J64
,
2YE5
,
2XDX
,
4O05
,
5J9X
,
2YK9
,
3R4N
,
7UR3
,
5LQ9
,
3HHU
,
7KW7
,
2XJJ
,
6GPT
,
3K98
,
7S9G
,
3OWD
,
4LWE
,
1UYD
,
3HZ1
,
2BT0
,
5OCI
,
4L94
,
2YE9
,
6TN5
,
2CCT
,
5LS1
,
6ELP
,
4L8Z
,
2YEJ
,
6GPH
,
3INX
,
4CWP
,
1OSF
,
2YKE
,
1UY7
,
3EKO
,
5J27
,
5LRL
,
2YI7
,
6GPW
,
4YKT
,
5FNC
,
5J8M
,
5XQD
,
5NYI
,
3B26
,
5XRD
,
3T0H
,
6LR9
,
2K5B
,
5M4H
,
3FT5
,
3R4M
,
2YE6
,
4FCP
,
4LWI
,
3R91
,
6FCJ
,
2XDK
,
7LSZ
,
4LWF
,
4CGU
,
4NH8
,
1UYE
,
6KSQ
,
2XDL
,
4YKY
,
3B24
,
2CCU
,
6U98
,
5LNY
,
3T2S
,
5J80
,
3HZ5
,
6GR4
,
1UYH
,
5VYY
,
2XHR
,
3B27
,
2YEB
,
5OD7
,
4U93
,
3Q6N
,
1UYI
,
8FFV
,
5XRE
,
6N8X
,
1UY6
,
4FCR
,
4CWR
,
1BYQ
,
7S90
,
3K99
,
3FT8
,
3BM9
,
6GPR
,
6GQR
,
4B7P
,
3OW6
,
3EKR
,
2UWD
,
6GP8
,
3T0Z
,
8B7I
,
5LO1
,
4NH7
,
5GGZ
,
4YKX
,
2YEF
,
4EGK
,
1UYF
,
2FWY
,
5LRZ
,
4YKU
,
5FND
,
8AGL
,
2H55
,
5T21
,
6ELN
,
4AWQ
,
6HHR
,
4FCQ
,
5NYH
,
6CYG
,
2XJG
,
4JQL
,
2YKI
,
8X2R
,
2YEC
,
7S8Z
,
2YJW
,
4W7T
,
6U9B
,
1YER
,
7S9H
,
5M4E
,
8KI4
,
6GQS
,
4EFU
,
4XIT
,
1YC1
,
6EYB
,
6U9A
,
2WI7
,
1YES
,
3TUH
,
5LR7
,
7S9F
,
4CWO
,
4L93
,
4XIP
,
3R4O
,
2YEH
,
2XK2
,
2XJX
,
5ODX
,
3OWB
,
2YKB
,
3HEK
,
1UY9
,
2FWZ
,
3Q6M
,
6LTK
,
2YI5
,
4O07
,
3RLR
,
5XR5
,
7S99
,
6B9A
,
5FNF
,
1UY8
,
4YKW
,
3QDD
,
2YI6
,
6GQ6
,
6ELO
,
2QFO
,
7RY1
,
2C2L
,
2YE3
,
8AGI
,
2QG0
,
2YE4
,
2YKJ
,
4EEH
,
6OLX
,
2JJC
,
4YKQ
,
6GP4
,
5XRB
,
2YEE
,
3HYY
,
2YE8
,
5J2V
,
5J82
,
4CGV
,
3WHA
,
3VHD
,
5LO5
,
6U99
,
4CWN
,
6EY9
,
5XR9
,
6GPP
,
5J6L
,
7LT0
,
6CEO
,
2WI3
,
3R92
,
4L91
,
5LR1
,
2VCI
,
2YE2
,
2YEI
,
3RLQ
,
6CYH
,
2WI4
,
6GR3
,
6LTI
,
2VCJ
,
4CWS
,
6B99
,
4BQJ
,
4LWG
,
5J2X
,
3B28
,
7DMC
,
2YE7
,
6EYA
,
5ZR3
,
2BSM
,
6F1N
,
5CF0
,
4HY6
,
7L7J
,
2YKC
,
4EGI
,
7L7I
,
1YC3
,
7KRJ
,
3WQ9
,
6TN4
,
6EY8
,
5LO0
,
3HYZ
,
2YEA
,
4CGW
,
8AGJ
,
7RY0
,
2YK2
,
3T1K
,
7S95
,
2WI5
,
6GQU
,
8FFW
,
5J20
,
2WI6
,
2QG2
,
4CGQ
,
5LO6
,
5J6M
,
5J86
,
4CWF
,
3VHA
,
4LWH
,
6LSZ
,
5J6N
,
3RKZ
,
1UYC
,
4CWT
,
3R4P
,
4EGH
,
3QTF
,
2QF6
,
5J8U
,
1YET
,
5LNZ
,
3INW
,
2BYH
,
3T10
,
4XIQ
,
4AIF
,
3O0I
,
4AWO
,
2BYI
,
6GPO
,
2XDS
,
2XAB
,
1YC4
,
3B25
,
8W4V
,
4O09
,
7RXZ
,
6EI5
,
4YKR
,
2XDU
,
2YJX
,
3K97
,
6GPY
,
2XHT
,
3MNR
,
3BMY
,
6GR1
,
1UYK
,
6LT8
,
7S8Y
,
4YKZ
,
7S9I
,
2YED
,
1UYL
,
8B7J
,
2XHX
ZINC - Investigational
HS90A_HUMAN
GeneCards
P07900
HPA
ENSG00000080824-HSP90AA1
Ensembl
ENSG00000080824
,
ENSP00000216281
,
ENST00000334701
,
ENST00000216281
,
ENSP00000335153
Pharos - Targets
P07900
ZINC - Predictions - Purchasable
HS90A_HUMAN
HMDB Protein
HMDBP02801
Interactors (111)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.899
17
UniProt:P53041 PPP5C
2
PPP5C [cytosol]
(R-HSA-5675402)
PPP5C [nucleoplasm]
(R-HSA-5683410)
0.873
13
UniProt:Q15185 PTGES3
2
PTGES3 [nucleoplasm]
(R-HSA-5082403)
PTGES3 [cytosol]
(R-HSA-265269)
0.857
9
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 Y772_A775dup [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.856
6
UniProt:P07900 HSP90AA1
8
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
0.851
6
UniProt:Q9H6T3 RPAP3
0.85
7
UniProt:P31948 STIP1
1
STIP1 [cytosol]
(R-HSA-443857)
0.832
7
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.831
9
UniProt:P06241 FYN
6
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
p-Y531-FYN [cytosol]
(R-HSA-391819)
MyrG2-PalmC3,6-FYN [plasma membrane]
(R-HSA-9606873)
p-Y420-FYN [cytosol]
(R-HSA-391821)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
FYN [cytosol]
(R-HSA-200917)
0.8
8
UniProt:Q13451 FKBP5
2
FKBP5 [cytosol]
(R-HSA-5618096)
FKBP5 [nucleoplasm]
(R-HSA-8939165)
0.8
9
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.788
7
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.788
15
UniProt:Q02790 FKBP4
3
FKBP4 [nucleoplasm]
(R-HSA-8939162)
FKBP4 [nucleoplasm]
(R-HSA-5324621)
FKBP4 [cytosol]
(R-HSA-5618108)
0.784
9
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.778
7
UniProt:P04150 NR3C1
3
SUMO1-K277,K293-NR3C1 [nucleoplasm]
(R-HSA-4341106)
NR3C1 [cytosol]
(R-HSA-5618118)
NR3C1 [nucleoplasm]
(R-HSA-879837)
0.775
8
UniProt:Q99558 MAP3K14
5
p-T559-MAP3K14 [cytosol]
(R-HSA-5668531)
K48polyUb-NIK [cytosol]
(R-HSA-5668525)
Active NIK [cytosol]
(R-HSA-5607646)
MAP3K14 [cytosol]
(R-HSA-168189)
p-MAP3K14 [cytosol]
(R-HSA-168187)
0.744
5
UniProt:Q15831 STK11
2
STK11 [cytosol]
(R-HSA-380954)
STK11 [nucleoplasm]
(R-HSA-164119)
0.744
6
UniProt:P50750 CDK9
1
CDK9 [nucleoplasm]
(R-HSA-51801)
0.744
6
UniProt:P04049 RAF1
20
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
0.744
15
UniProt:P08107 HSP71
0.723
4
UniProt:Q9UHD1 CHRD1
0.681
8
UniProt:P05412 JUN
4
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
0.678
4
UniProt:Q6VAB6 KSR2
1
KSR2 [cytosol]
(R-HSA-5672589)
0.669
6
UniProt:Q9BXA6 TSSK6
0.669
4
UniProt:Q8IWD4 CC117
0.669
7
UniProt:O15111 CHUK
4
CHUK [cytosol]
(R-HSA-168104)
p-S176,S180-CHUK [cytosol]
(R-HSA-177667)
p-T23-CHUK [cytosol]
(R-HSA-198615)
p-Y187,Y198-CHUK [cytosol]
(R-HSA-9861501)
0.669
4
UniProt:Q96QS6 PSKH2
0.669
3
UniProt:Q14318 FKBP8
2
PolyUb-FKBP8 [mitochondrial outer membrane]
(R-HSA-6783001)
FKBP8 [mitochondrial outer membrane]
(R-HSA-5696928)
0.669
8
UniProt:Q9Y6K9 IKBKG
12
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG [nucleoplasm]
(R-HSA-4755413)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
IKBKG [cytosol]
(R-HSA-168108)
0.669
4
UniProt:P12931 SRC
6
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [cytosol]
(R-HSA-8964276)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.669
3
UniProt:P17612 PRKACA
4
PRKACA [mitochondrial matrix]
(R-HSA-9838291)
PRKACA [ciliary base]
(R-HSA-5610402)
PRKACA [nucleoplasm]
(R-HSA-111936)
PRKACA [cytosol]
(R-HSA-57844)
0.666
4
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.666
5
UniProt:Q9UQM7 CAMK2A
6
p-T286-CAMK2A [plasma membrane]
(R-HSA-432796)
p-T286-CAMK2A [nucleoplasm]
(R-HSA-444797)
p-T286-CAMK2A [endocytic vesicle membrane]
(R-HSA-416999)
p-T286,T305,T306-CAMK2A [cytosol]
(R-HSA-4332334)
CAMK2A [cytosol]
(R-HSA-4332329)
p-T286-CAMK2A [cytosol]
(R-HSA-445368)
0.666
5
UniProt:O95433 AHSA1
0.659
6
UniProt:P11802 CDK4
3
CDK4 [cytosol]
(R-HSA-68330)
CDK4 [nucleoplasm]
(R-HSA-113843)
p-T172-CDK4 [nucleoplasm]
(R-HSA-113830)
0.643
4
UniProt:P61247 RPS3A
2
RPS3A [nucleoplasm]
(R-HSA-6791182)
RPS3A [cytosol]
(R-HSA-72373)
0.635
3
UniProt:O43318-2 MAP3K7
0.623
5
UniProt:P35467
1
S100A1 [extracellular region]
(R-RNO-6805991)
0.618
4
UniProt:Q8WVJ2 NUDC2
0.612
4
UniProt:P43034 PAFAH1B1
1
PAFAH1B1 [cytosol]
(R-HSA-376249)
0.612
5
UniProt:Q9H0C5 BTBD1
1
BTBD1 [cytosol]
(R-HSA-8851650)
0.61
4
UniProt:Q9Y239 NOD1
1
NOD1 [cytosol]
(R-HSA-168407)
0.589
2
UniProt:Q13127 REST
1
REST [nucleoplasm]
(R-HSA-480506)
0.57
4
UniProt:P14616 INSRR
0.569
3
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.569
11
UniProt:Q7L3B6 CDC37L1
2
CDC37L1 [extracellular region]
(R-HSA-8848918)
CDC37L1 [platelet dense granule lumen]
(R-HSA-8848903)
0.564
3
UniProt:Q96Q40 CDK15
0.564
3
UniProt:Q15750 TAB1
6
TAB1(445-504) [cytosol]
(R-HSA-9729691)
TAB1(133-504) [cytosol]
(R-HSA-9729724)
TAB1(1-132) [cytosol]
(R-HSA-9729698)
TAB1(1-444) [cytosol]
(R-HSA-9729751)
TAB1 [endosome membrane]
(R-HSA-450238)
TAB1 [cytosol]
(R-HSA-167923)
0.564
2
UniProt:Q9NYJ8 TAB2
4
TAB2 [cytosol]
(R-HSA-168117)
TAB2 [endosome membrane]
(R-HSA-450279)
TAB2 [plasma membrane]
(R-HSA-168116)
TAB2 [nucleoplasm]
(R-HSA-1253323)
0.564
2
UniProt:P06239 LCK
4
p-Y394-LCK [plasma membrane]
(R-HSA-8857940)
p-Y505-LCK [plasma membrane]
(R-HSA-202159)
p-Y394-LCK [cytosol]
(R-HSA-202308)
LCK [cytosol]
(R-HSA-167609)
0.564
3
UniProt:Q9Y243 AKT3
6
p-T305-AKT3 [cytosol]
(R-HSA-3009370)
AKT3 [cytosol]
(R-HSA-2976007)
AKT3 [plasma membrane]
(R-HSA-2976006)
p-S472-AKT3 [plasma membrane]
(R-HSA-3009363)
p-T305,S472-AKT3 [cytosol]
(R-HSA-3009367)
p-T305,S472-AKT3 [nucleoplasm]
(R-HSA-3009365)
0.564
4
UniProt:P00540 MOS
0.564
2
UniProt:Q16671 AMHR2
1
AMHR2 [plasma membrane]
(R-HSA-8858258)
0.564
3
UniProt:Q8IWX7 UN45B
0.564
3
UniProt:Q9NR20 DYRK4
0.564
2
UniProt:Q9UHH9 IP6K2
1
IP6K2 [nucleoplasm]
(R-HSA-1015687)
0.558
2
UniProt:Q14194 CRMP1
4
p-Y-CRMP1 [cytosol]
(R-HSA-399784)
CRMP1 [cytosol]
(R-HSA-398120)
p-T509,T514,S518,S522-CRMP1 [cytosol]
(R-HSA-399777)
p-S522-CRMP1 [cytosol]
(R-HSA-399779)
0.556
3
UniProt:Q92993-2 KAT5
0.556
3
UniProt:Q15438 CYTH1
2
CYTH1 [cytosol]
(R-HSA-8847826)
CYTH1 [Golgi membrane]
(R-HSA-8847825)
0.556
3
UniProt:Q8WUY3 PRUN2
0.556
3
UniProt:Q6UY14-3 ADAMTSL4
0.556
3
UniProt:Q6QEF8-4 CORO6
0.556
3
UniProt:Q9H6R7-2 Q9H6R72
0.556
3
UniProt:Q9BV29 CCD32
0.556
3
UniProt:Q96LI6-3 Q96LI63
0.556
3
UniProt:P10599 TXN
4
2xHC-TXN [nucleoplasm]
(R-HSA-9617733)
TXN [nucleoplasm]
(R-HSA-9617732)
2xHC-TXN [cytosol]
(R-HSA-73668)
TXN [cytosol]
(R-HSA-66000)
0.556
3
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.556
3
UniProt:P07814 EPRS1
1
EPRS [cytosol]
(R-HSA-379649)
0.544
2
UniProt:P26196 DDX6
1
DDX6 [cytosol]
(R-HSA-430032)
0.536
2
UniProt:Q9H1R3 MYLK2
0.527
8
UniProt:P68371 TUBB4B
8
TUBB4B [cytosol]
(R-HSA-191702)
TUBB4B [azurophil granule lumen]
(R-HSA-6799347)
TUBB4B [extracellular region]
(R-HSA-6806178)
TUBB4B [axonemal microtubule]
(R-HSA-5610441)
Polyglutamyl-TUBB4B [cytosol]
(R-HSA-8867427)
Polyglycyl-TUBB4B [cytosol]
(R-HSA-8867452)
TUBB4B unfolded [cytosol]
(R-HSA-392779)
TUBB4B folding intermediate [cytosol]
(R-HSA-392788)
0.527
2
UniProt:Q71U36 TUBA1A
9
AcK-TUBA1A [cytosol]
(R-HSA-5618312)
Ac K40 TUBA1A [axonemal microtubule]
(R-HSA-5624852)
TUBA1A folding intermediate [cytosol]
(R-HSA-392805)
TUBA1A unfolded [cytosol]
(R-HSA-392767)
L-isoglutamyl polyglycyl-TUBA1A [cytosol]
(R-HSA-8867428)
Polyglutamyl-TUBA1A [cytosol]
(R-HSA-8867408)
TUBA1A(1-450) [cytosol]
(R-HSA-8955577)
TUBA1A [cytosol]
(R-HSA-191689)
TUBA1A [axonemal microtubule]
(R-HSA-5610433)
0.527
3
UniProt:P08631 HCK
2
p-HCK [cytosol]
(R-HSA-9676060)
HCK [cytosol]
(R-HSA-167708)
0.527
3
UniProt:Q3B7T1 EDRF1
0.527
6
UniProt:Q8N5M4 TTC9C
0.527
5
UniProt:O75676 RPS6KA4
1
RPS6KA4 [cytosol]
(R-HSA-772527)
0.527
3
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
0.527
3
UniProt:Q9HBY8 SGK2
1
SGK2 [cytosol]
(R-HSA-2682364)
0.527
2
UniProt:P19388 POLR2E
2
POLR2E [nucleoplasm]
(R-HSA-83713)
POLR2E [cytosol]
(R-HSA-1964438)
0.527
3
UniProt:Q9H9G7 AGO3
1
EIF2C3 [cytosol]
(R-HSA-210615)
0.527
2
UniProt:P10398 ARAF
4
p-S299,S302,T452,T455,S582 ARAF [cytosol]
(R-HSA-5672646)
p-S299,S302,T452,T455,S582 ARAF [plasma membrane]
(R-HSA-5672648)
p-S582 ARAF [cytosol]
(R-HSA-5672681)
p-S214,S582 ARAF [cytosol]
(R-HSA-5672639)
0.527
3
UniProt:Q13131 PRKAA1
3
p-T183-PRKAA1 [cytosol]
(R-HSA-380964)
PRKAA1 [cytosol]
(R-HSA-380935)
p-T183-PRKAA1 [nucleoplasm]
(R-HSA-2151206)
0.527
2
UniProt:Q6J9G0 STYK1
0.527
2
UniProt:Q92918 M4K1
0.527
2
UniProt:Q15785 TOM34
0.527
4
UniProt:Q8NFD2 ANKK1
0.527
2
UniProt:Q9UQ88 CDK11A
1
CDK11A [cytosol]
(R-HSA-380457)
0.527
4
UniProt:P49761 CLK3
0.527
2
UniProt:Q13618 CUL3
3
G76-NEDD8-K712-CUL3 [cytosol]
(R-HSA-8952516)
CUL3 [nucleoplasm]
(R-HSA-5635033)
CUL3 [cytosol]
(R-HSA-975979)
0.527
2
UniProt:P11142 HSPA8
10
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [cytosol]
(R-HSA-264476)
0.527
2
UniProt:P36507 MAP2K2
12
MAP2K2(1-10) [cytosol]
(R-HSA-5211334)
MAP2K2(11-400) [cytosol]
(R-HSA-5211337)
MAP2K2 C125S [cytosol]
(R-HSA-9652070)
MAP2K2 P128Q [cytosol]
(R-HSA-9652082)
MAP2K2 V35M [cytosol]
(R-HSA-9652086)
MAP2K2 Y134C [cytosol]
(R-HSA-9652089)
p-S222,S226-MAP2K2 [cytosol]
(R-HSA-169292)
MAP2K2 [cytosol]
(R-HSA-59504)
p-S,T-MAP2K2 [cytosol]
(R-HSA-109848)
MAP2K2 N126D [cytosol]
(R-HSA-9652079)
MAP2K2 L46F [cytosol]
(R-HSA-9652076)
MAP2K2 F57C [cytosol]
(R-HSA-9652073)
0.527
3
UniProt:O94966 USP19
1
USP19 [cytosol]
(R-HSA-6781794)
0.527
7
UniProt:P51451 BLK
2
MyrG2-BLK [plasma membrane]
(R-HSA-9606871)
BLK [cytosol]
(R-HSA-983580)
0.527
3
UniProt:P48729 CSNK1A1
2
CSNK1A1 [cytosol]
(R-HSA-195263)
CSNK1A1 [cilium]
(R-HSA-5632507)
0.527
4
UniProt:Q96GD4 AURKB
3
polySUMO2,3-K202-AURKB [cytosol]
(R-HSA-4655414)
AURKB [nucleoplasm]
(R-HSA-4655360)
AURKB [cytosol]
(R-HSA-174231)
0.527
2
UniProt:Q13163 MAP2K5
1
MAP2K5 [cytosol]
(R-HSA-198722)
0.527
3
UniProt:P34932 HSPA4
2
HSPA4 [cytosol]
(R-HSA-5251946)
HSPA4 [nucleoplasm]
(R-HSA-5251998)
0.527
2
UniProt:O95801 TTC4
0.527
4
UniProt:Q8TDR2 STK35
0.527
3
UniProt:Q14004 CDK13
3
CDK13 [nucleoplasm]
(R-HSA-6797014)
CDK13 [ficolin-1-rich granule lumen]
(R-HSA-6801374)
CDK13 [extracellular region]
(R-HSA-6806442)
0.527
3
UniProt:Q8WTQ7 GRK7
1
GRK7 [photoreceptor disc membrane]
(R-HSA-6787797)
0.527
2
UniProt:Q8N165 PDK1L
0.527
2
UniProt:Q86YV6 MYLK4
0.527
2
UniProt:Q15418 RPS6KA1
7
RPS6KA1 [nucleoplasm]
(R-HSA-199860)
p-4S,T359,T573-RPS6KA1 [nucleoplasm]
(R-HSA-199829)
RPS6KA1 [cytosol]
(R-HSA-444256)
p-T359,S363,T573-RPS6KA1 [cytosol]
(R-HSA-9619957)
p-S221,T459,S363,S380,T573,S732-RPS6KA1 [cytosol]
(R-HSA-9619871)
p-T359,S363,S380.T573,S732-RPS6KA1 [cytosol]
(R-HSA-9619993)
p-S221,T359,S363,S380,T573,S732-RPS6KA1 [nucleoplasm]
(R-HSA-444292)
0.527
3
UniProt:Q9H3Y6 SRMS
1
SRMS [cytosol]
(R-HSA-3902520)
0.527
3
UniProt:Q08881 ITK
3
p-Y180,Y512-ITK [cytosol]
(R-HSA-2685616)
p-Y512-ITK [cytosol]
(R-HSA-422519)
ITK [cytosol]
(R-HSA-202319)
0.527
2
UniProt:P26882 PPID
0.525
4
UniProt:Q96G23 CERS2
1
CERS2 [endoplasmic reticulum membrane]
(R-HSA-428171)
0.524
2
UniProt:Q9D1P4 CHRD1
0.508
3
UniProt:P12830 CDH1
8
CDH1(732-882) [plasma membrane]
(R-HSA-3827997)
CDH1(155-700) [plasma membrane]
(R-HSA-2534244)
CDH1(701-882) [extracellular region]
(R-HSA-2534158)
Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane]
(R-HSA-8877002)
p-Y753,Y754-CDH1(155-882) [plasma membrane]
(R-HSA-8876938)
CDH1(155-750) [plasma membrane]
(R-HSA-202940)
CDH1(751-882) [plasma membrane]
(R-HSA-202929)
CDH1(155-882) [plasma membrane]
(R-HSA-198003)
0.499
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
13
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