Synthesis of PB1-F2

Stable Identifier
R-HSA-192704
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Synthesis of PB1-F2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
For most influenza A strains (such as PR8), the PB1 mRNA segment produces a second protein, PB1-F2, from the +1 open reading frame (Chen, 2001). PB1-F2 is a pro-apoptotic, mitochondria-localized protein (Chen, 2001; Gibbs, 2003) that oligomerizes (Bruns, 2007) and sensitizes cells to death in concert with the mitochondrial ANT3 and VDAC proteins (Zamarin, 2005).
Literature References
PubMed ID Title Journal Year
11726970 A novel influenza A virus mitochondrial protein that induces cell death

Chen, W, Palese, P, Malide, D, Calvo, PA, Gibbs, J, Henklein, P, Bennink, JR, Basta, S, Schickli, J, Yewdell, JW, Bacik, I, O'Neill, R, Schubert, U

Nat Med 2001
Participants
Input
Output
Participates
as an event of
Catalyst Activity

translation elongation factor activity of 80S ribosome [cytosol]

Physical Entity
80S ribosome [cytosol] (Homo sapiens)
Activity
translation elongation factor activity (GO:0003746)
Disease
Name Identifier Synonyms
influenza DOID:8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Authored
Garcia-Sastre, A  (2007-02-13)
Bortz, E  (2007-02-13)
Reviewed
Squires, B  (2007-02-13)
Created
Gillespie, ME  (2007-02-07)
Cite Us!