Synthesis of PB1-F2

Stable Identifier
R-HSA-192704
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
Locations in the PathwayBrowser
General
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For most influenza A strains (such as PR8), the PB1 mRNA segment produces a second protein, PB1-F2, from the +1 open reading frame (Chen, 2001). PB1-F2 is a pro-apoptotic, mitochondria-localized protein (Chen, 2001; Gibbs, 2003) that oligomerizes (Bruns, 2007) and sensitizes cells to death in concert with the mitochondrial ANT3 and VDAC proteins (Zamarin, 2005).

Literature References
PubMed ID Title Journal Year
11726970 A novel influenza A virus mitochondrial protein that induces cell death

Chen, W, Calvo, PA, Malide, D, Gibbs, J, Schubert, U, Bacik, I, Basta, S, O'Neill, R, Schickli, J, Palese, P, Henklein, P, Bennink, JR, Yewdell, JW

Nat Med 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
translation elongation factor activity of 80S ribosome [cytosol]
Physical Entity
Activity
Disease
Name Identifier Synonyms
influenza 8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Authored
Reviewed
Created
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