Viral mRNA Export

Stable Identifier
R-HSA-192627
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
nucleoplasm
ReviewStatus
5/5
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Viral mRNA Export
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The viral polymerase complex produces positive-sense viral mRNA with host-cell derived 5' methyl caps. Capped viral mRNAs are selectively exported from the host cell nucleus through a currently unclear mechanism that may rely on components of the host cell mRNA export machinery (Chen, 2000; Engelhardt, 2006). Polyadenylation of viral mRNA appears be required for influenza mRNA export (Poon, 2000). A coupling of viral mRNA export with cellular pre-mRNA processing complexes, recruited by phosphorylation of host RNA polymerase II C-terminal domain which interacts with the viral polymerase (Engelhardt, 2005), has been proposed as controlling the export of a subset (M1, HA, and NS1, but not NP) of viral mRNA from the nucleus (Amorim, 2007).
Literature References
PubMed ID Title Journal Year
17132145 Nuclear Export of Influenza A Virus mRNAs Requires Ongoing RNA Polymerase II Activity

Amorim, MJ, Digard, P, Medcalf, L, Dalton, RM, Read, EK

Traffic 2007
16933365 Functional association between viral and cellular transcription during influenza virus infection

Fodor, E, Engelhardt, OG

Rev Med Virol 2006
10920397 Selective nuclear export of viral mRNAs in influenza-virus-infected cells

Chen, Z, Krug, RM

Trends Microbiol 2000
Participants
Input
Output
Participates
as an event of
Catalyst Activity

structural constituent of nuclear pore activity of Nuclear Pore Complex (NPC) [nuclear envelope]

Physical Entity
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
Activity
structural constituent of nuclear pore (GO:0017056)
Disease
Name Identifier Synonyms
influenza DOID:8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Authored
Garcia-Sastre, A  (2007-02-13)
Bortz, E  (2007-02-13)
Reviewed
Squires, B  (2007-02-13)
Created
Gillespie, ME  (2007-02-07)
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