Viral mRNA Export

Stable Identifier
R-HSA-192627
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
nucleoplasm
ReviewStatus
5/5
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Viral mRNA Export
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The viral polymerase complex produces positive-sense viral mRNA with host-cell derived 5' methyl caps. Capped viral mRNAs are selectively exported from the host cell nucleus through a currently unclear mechanism that may rely on components of the host cell mRNA export machinery (Chen, 2000; Engelhardt, 2006). Polyadenylation of viral mRNA appears be required for influenza mRNA export (Poon, 2000). A coupling of viral mRNA export with cellular pre-mRNA processing complexes, recruited by phosphorylation of host RNA polymerase II C-terminal domain which interacts with the viral polymerase (Engelhardt, 2005), has been proposed as controlling the export of a subset (M1, HA, and NS1, but not NP) of viral mRNA from the nucleus (Amorim, 2007).
Literature References
PubMed ID Title Journal Year
17132145 Nuclear Export of Influenza A Virus mRNAs Requires Ongoing RNA Polymerase II Activity

Amorim, MJ, Read, EK, Dalton, RM, Medcalf, L, Digard, P

Traffic 2007
16933365 Functional association between viral and cellular transcription during influenza virus infection

Engelhardt, OG, Fodor, E

Rev Med Virol 2006
10920397 Selective nuclear export of viral mRNAs in influenza-virus-infected cells

Chen, Z, Krug, RM

Trends Microbiol 2000
Participants
Input
Output
Participates
as an event of
Catalyst Activity

structural constituent of nuclear pore activity of Nuclear Pore Complex (NPC) [nuclear envelope]

Physical Entity
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
Activity
structural constituent of nuclear pore (GO:0017056)
Disease
Name Identifier Synonyms
influenza DOID:8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Cross References
Mondo
Authored
Bortz, E  (2007-02-13)
Garcia-Sastre, A  (2007-02-13)
Reviewed
Squires, B  (2007-02-13)
Created
Gillespie, ME  (2007-02-07)
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