Reactome | cRNA Extension

cRNA Extension

Stable Identifier

R-HSA-192624

Type

Reaction [transition]

Species

Homo sapiens

Related Species

Influenza A virus

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Influenza Infection (Homo sapiens)
      - Influenza Viral RNA Transcription and Replication (Homo sapiens)
        
        cRNA Synthesis (Homo sapiens)
        
        cRNA Extension (Homo sapiens)

General

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Virion vRNP is capable of synthesizing cRNA immediately following entry into the cell nucleus (Vreede, 2006). The PB1 subunit principally catalyzes extension (Nakagawa, 1996). However, cRNA does not accumulate until later in the infection process, possiby requiring NP and the trimeric polymerase for stabilization (Vreede, 2004). The vRNA template is released.

Literature References

PubMed ID	Title	Journal	Year
15308750	Model suggesting that replication of influenza virus is regulated by stabilization of replicative intermediates Vreede, FT, Jung, TE, Brownlee, GG	J Virol	2004
17166911	Influenza virion-derived viral ribonucleoproteins synthesize both mRNA and cRNA in vitro Vreede, FT, Brownlee, GG	J Virol	2006
8709268	The PB1 subunit alone can catalyze cRNA synthesis, and the PA subunit in addition to the PB1 subunit is required for viral RNA synthesis in replication of the influenza virus genome Nakagawa, Y, Oda, K, Nakada, S	J Virol	1996

Participants

Input

Output

Participates

as an event of

cRNA Synthesis (Homo sapiens)

Catalyst Activity

RNA-directed RNA polymerase activity of Viral Polymerase [nucleoplasm]

Physical Entity

Viral Polymerase [nucleoplasm] (Influenza A virus)

Activity

RNA-directed RNA polymerase activity (GO:0003968)

Disease

Name	Identifier	Synonyms
influenza	DOID:8469	Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation

Cross References

Mondo

0005812

Authored

Bortz, E (2007-02-13)

Garcia-Sastre, A (2007-02-13)

Reviewed

Squires, B (2007-02-13)

Created

Gillespie, ME (2007-02-07)

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