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What is Reactome ?
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Release Calendar
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License Agreement
Privacy Notice
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Digital Preservation
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Table of Contents
DOIs
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ORCID Integration Project
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Docs
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Activated FGFR2c short homodimer bound to FGF [plasma membrane]
Stable Identifier
R-HSA-192592
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR2:pY-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by FGFR (Homo sapiens)
Signaling by FGFR2 (Homo sapiens)
Downstream signaling of activated FGFR2 (Homo sapiens)
FRS-mediated FGFR2 signaling (Homo sapiens)
Activated FGFR2 binds FRS2 (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2 binds FRS3 (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2 phosphorylates FRS2 (Homo sapiens)
Activated FGFR2:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:p-8T-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2 phosphorylates FRS3 (Homo sapiens)
Activated FGFR2:FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2 phosphorylates PPTN11 (Homo sapiens)
Activated FGFR2:p-FRS:PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS bind to PPTN11 (Homo sapiens)
Activated FGFR2:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS:PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR2:p-FRS:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:pFRS binds GRB2:SOS1 (Homo sapiens)
Activated FGFR2:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
PI-3K cascade:FGFR2 (Homo sapiens)
Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)
Activated FGFR2:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Homo sapiens)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Homo sapiens)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Phospholipase C-mediated cascade; FGFR2 (Homo sapiens)
Activated FGFR2 binds PLCG1 (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
activated FGFR2:PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2 phosphorylates PLCG1 (Homo sapiens)
activated FGFR2:PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
activated FGFR2:p-4Y-PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
p-4Y-PLCG1 dissociates from activated FGFR2 (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
activated FGFR2:p-4Y-PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
SHC-mediated cascade:FGFR2 (Homo sapiens)
Activated FGFR2 binds SHC1 (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2 phosphorylates SHC1 (Homo sapiens)
Activated FGFR2:SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:pY-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Homo sapiens)
Activated FGFR2:pY-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR2:pY-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR2:pY-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
FGFR2 ligand binding and activation (Homo sapiens)
FGFR2c ligand binding and activation (Homo sapiens)
Autocatalytic phosphorylation of FGFR2c (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Negative regulation of FGFR2 signaling (Homo sapiens)
Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Homo sapiens)
Activated FGFR2:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:p-8T-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
CBL ubiquitinates FRS2 and FGFR2 (Homo sapiens)
Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Homo sapiens)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [cytosol] (Homo sapiens)
Activated FGFR bound to PI3K [cytosol] (Homo sapiens)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
IGF1R signaling cascade (Homo sapiens)
IRS-related events triggered by IGF1R (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [cytosol] (Homo sapiens)
Activated FGFR bound to PI3K [cytosol] (Homo sapiens)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR [plasma membrane] (Homo sapiens)
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Activated FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
Participants
components
x 2
FGFR2c-binding FGFs [extracellular region]
(Homo sapiens)
HS [extracellular region]
x 2
p-8Y-FGFR2-5 [plasma membrane]
(Homo sapiens)
Participates
as a member of
Activated FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
Inferred To
Activated FGFR2c short homodimer bound to FGF [plasma membrane]
(Bos taurus)
Activated FGFR2c short homodimer bound to FGF [plasma membrane]
(Caenorhabditis elegans)
Activated FGFR2c short homodimer bound to FGF [plasma membrane]
(Canis familiaris)
Activated FGFR2c short homodimer bound to FGF [plasma membrane]
(Danio rerio)
Activated FGFR2c short homodimer bound to FGF [plasma membrane]
(Drosophila melanogaster)
Activated FGFR2c short homodimer bound to FGF [plasma membrane]
(Gallus gallus)
Activated FGFR2c short homodimer bound to FGF [plasma membrane]
(Mus musculus)
Activated FGFR2c short homodimer bound to FGF [plasma membrane]
(Rattus norvegicus)
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