Reactome | Digestion of triacylglycerols by extracellular PTL:colipase

Digestion of triacylglycerols by extracellular PTL:colipase

Stable Identifier

R-HSA-192422

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Digestion of triacylglycerols by extracellular PTL:colipase

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Pancreatic lipase catalyzes the hydrolysis of extracellular triacylglycerols to yield diacylglycerols and long-chain fatty acids. The enzyme is active only when complexed with colipase protein and plays a major role in the digestion of dietary triacylglycerols in the small intestine (Carriere et al. 2000; Giller et al. 1992).

Literature References

PubMed ID	Title	Journal	Year
1379598	Two novel human pancreatic lipase related proteins, hPLRP1 and hPLRP2. Differences in colipase dependence and in lipase activity. Buchwald, P, Giller, T, Hunziker, W, Blum-Kaelin, D	J Biol Chem	1992
11040182	The specific activities of human digestive lipases measured from the in vivo and in vitro lipolysis of test meals Ferrato, F, De Caro, J, Verger, R, Laugier, R, Renou, C, Lopez, V, Lengsfeld, H, Carriere, F, De Caro, A	Gastroenterology	2000