3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA

Stable Identifier
R-HSA-192331
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O => (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA
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3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to form (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA. This reaction, catalyzed by the peroxisomal D-bifunctional enzyme (Huyghe et al. 2006), occurs in the peroxisomal matrix.

Literature References
PubMed ID Title Journal Year
8902629 Purification and properties of human D-3-hydroxyacyl-CoA dehydratase: medium-chain enoyl-CoA hydratase is D-3-hydroxyacyl-CoA dehydratase

Jiang, LL, Kobayashi, A, Matsuura, H, Fukushima, H, Hashimoto, T

J Biochem (Tokyo) 1996
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity of HSD17B4 dimer [peroxisomal matrix]
Physical Entity
Activity
Orthologous Events
Authored
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